Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND MAP2K4, MEK4, 6416, P45985, ENSG00000065559, SERK1, JNKK1, MKK4, PRKMK4, MAPKK4, JNKK, SEK1
26 results:

  • 1. Small-molecule inhibition of map2k4 is synergistic with RAS inhibitors in
    Jansen RA; Mainardi S; Dias MH; Bosma A; van Dijk E; Selig R; Albrecht W; Laufer SA; Zender L; Bernards R
    Proc Natl Acad Sci U S A; 2024 Feb; 121(9):e2319492121. PubMed ID: 38377196
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study.
    Wang J; Xiu J; Farrell A; Baca Y; Arai H; Battaglin F; Kawanishi N; Soni S; Zhang W; Millstein J; Shields AF; Grothey A; Weinberg BA; Marshall JL; Lou E; Khushman M; Sohal DPS; Hall MJ; Liu T; Oberley M; Spetzler D; Korn WM; Shen L; Lenz HJ
    Lancet Oncol; 2023 Feb; 24(2):151-161. PubMed ID: 36681091
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. Fusobacterium nucleatum induces excess methyltransferase-like 3-mediated microRNA-4717-3p maturation to promote colorectal cancer cell proliferation.
    Xu Q; Lu X; Li J; Feng Y; Tang J; Zhang T; Mao Y; Lan Y; Luo H; Zeng L; Xiang Y; Hu L; Zhang Y; Li Q; Deng L; He X; Tang B; Mao X; Zeng D
    Cancer Sci; 2022 Nov; 113(11):3787-3800. PubMed ID: 35984699
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Combined high energy of extracorporeal shock wave and 5-FU effectively suppressed the proliferation and growth of tongue squamous cell carcinoma.
    Chang CL; Chen KH; Sung PH; Chiang JY; Huang CR; Chen HH; Yip HK
    Biomed Pharmacother; 2021 Oct; 142():112036. PubMed ID: 34411913
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
    Zaidi SH; Harrison TA; Phipps AI; Steinfelder R; Trinh QM; Qu C; Banbury BL; Georgeson P; Grasso CS; Giannakis M; Adams JB; Alwers E; Amitay EL; Barfield RT; Berndt SI; Borozan I; Brenner H; Brezina S; Buchanan DD; Cao Y; Chan AT; Chang-Claude J; Connolly CM; Drew DA; Farris AB; Figueiredo JC; French AJ; Fuchs CS; Garraway LA; Gruber S; Guinter MA; Hamilton SR; Harlid S; Heisler LE; Hidaka A; Hopper JL; Huang WY; Huyghe JR; Jenkins MA; Krzyzanowski PM; Lemire M; Lin Y; Luo X; Mardis ER; McPherson JD; Miller JK; Moreno V; Mu XJ; Nishihara R; Papadopoulos N; Pasternack D; Quist MJ; Rafikova A; Reid EEG; Shinbrot E; Shirts BH; Stein LD; Teney CD; Timms L; Um CY; Van Guelpen B; Van Tassel M; Wang X; Wheeler DA; Yung CK; Hsu L; Ogino S; Gsur A; Newcomb PA; Gallinger S; Hoffmeister M; Campbell PT; Thibodeau SN; Sun W; Hudson TJ; Peters U
    Nat Commun; 2020 Jul; 11(1):3644. PubMed ID: 32686686
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Is there any correlation among mkk4
    Dogan M; Guresci S; Acikgoz Y; Ergun Y; Kos FT; Bozdogan O; Bal O
    Expert Rev Mol Diagn; 2020 Aug; 20(8):851-859. PubMed ID: 32552144
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. Protein kinase p38α signaling in dendritic cells regulates colon inflammation and tumorigenesis.
    Zheng T; Zhang B; Chen C; Ma J; Meng D; Huang J; Hu R; Liu X; Otsu K; Liu AC; Li H; Yin Z; Huang G
    Proc Natl Acad Sci U S A; 2018 Dec; 115(52):E12313-E12322. PubMed ID: 30541887
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. MAP3K1 and map2k4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models.
    Xue Z; Vis DJ; Bruna A; Sustic T; van Wageningen S; Batra AS; Rueda OM; Bosdriesz E; Caldas C; Wessels LFA; Bernards R
    Cell Res; 2018 Jul; 28(7):719-729. PubMed ID: 29795445
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. Downregulation of phosphorylated mkk4 is associated with a poor prognosis in colorectal cancer patients.
    Wang PN; Huang J; Duan YH; Zhou JM; Huang PZ; Fan XJ; Huang Y; Wang L; Liu HL; Wang JP; Huang MJ
    Oncotarget; 2017 May; 8(21):34352-34361. PubMed ID: 28423721
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. Whole-exome sequencing identified mutational profiles of high-grade colon adenomas.
    Lee SH; Jung SH; Kim TM; Rhee JK; Park HC; Kim MS; Kim SS; An CH; Lee SH; Chung YJ
    Oncotarget; 2017 Jan; 8(4):6579-6588. PubMed ID: 28179590
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. A redox state-dictated signalling pathway deciphers the malignant cell specificity of CD40-mediated apoptosis.
    Dunnill CJ; Ibraheem K; Mohamed A; Southgate J; Georgopoulos NT
    Oncogene; 2017 May; 36(18):2515-2528. PubMed ID: 27869172
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. Associations between CYP1A1 rs1048943 A > G and rs4646903 T > C genetic variations and colorectal cancer risk: Proof from 26 case-control studies.
    Zhu X; Wang Z; He J; Wang W; Xue W; Wang Y; Zheng L; Zhu ML
    Oncotarget; 2016 Aug; 7(32):51365-51374. PubMed ID: 27384991
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. ent-kaurane diterpenoids from Croton tonkinensis induce apoptosis in colorectal cancer cells through the phosphorylation of JNK mediated by reactive oxygen species and dual-specificity JNK kinase mkk4.
    Thuong PT; Khoi NM; Ohta S; Shiota S; Kanta H; Takeuchi K; Ito F
    Anticancer Agents Med Chem; 2014; 14(7):1051-61. PubMed ID: 24476312
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. Modeling RAS phenotype in colorectal cancer uncovers novel molecular traits of RAS dependency and improves prediction of response to targeted agents in patients.
    Guinney J; Ferté C; Dry J; McEwen R; Manceau G; Kao KJ; Chang KM; Bendtsen C; Hudson K; Huang E; Dougherty B; Ducreux M; Soria JC; Friend S; Derry J; Laurent-Puig P
    Clin Cancer Res; 2014 Jan; 20(1):265-272. PubMed ID: 24170544
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. [Expression and clinicopathological significance of serine-257/threonine-261 phosphorylated mkk4 in colorectal carcinoma].
    Huang MJ; Wang PN; Huang J; Zhang XW; Wang L; Liu HL; Wang JP
    Zhonghua Yi Xue Za Zhi; 2013 Mar; 93(10):746-50. PubMed ID: 23755811
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. c-Jun N-terminal kinase 1 (JNK1) is required for coordination of netrin signaling in axon guidance.
    Qu C; Li W; Shao Q; Dwyer T; Huang H; Yang T; Liu G
    J Biol Chem; 2013 Jan; 288(3):1883-95. PubMed ID: 23223444
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Comprehensive mutation analysis in colorectal flat adenomas.
    Voorham QJ; Carvalho B; Spiertz AJ; Claes B; Mongera S; van Grieken NC; Grabsch H; Kliment M; Rembacken B; van de Wiel MA; Quirke P; Mulder CJ; Lambrechts D; van Engeland M; Meijer GA
    PLoS One; 2012; 7(7):e41963. PubMed ID: 22848674
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. The protective role of polymorphism mkk4-1304 T>G in nasopharyngeal carcinoma is modulated by Epstein-Barr virus' infection status.
    Zheng J; Liu B; Zhang L; Jiang L; Huang B; You Y; Jiang Q; Zhang S; Lu J; Zhou Y
    Int J Cancer; 2012 May; 130(9):1981-90. PubMed ID: 21702039
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. The association between -1304T>G polymorphism in the promoter of mkk4 gene and the risk of sporadic colorectal cancer in southern Chinese population.
    Wei Y; Wang L; Lan P; Zhao H; Pan Z; Huang J; Lu J; Wang J
    Int J Cancer; 2009 Oct; 125(8):1876-83. PubMed ID: 19610067
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. MAP kinases in proliferating human colon cancer Caco-2 cells.
    Buzzi N; Colicheo A; Boland R; de Boland AR
    Mol Cell Biochem; 2009 Aug; 328(1-2):201-8. PubMed ID: 19301097
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