Terms: = Colorectal cancer AND MDM2, HDM2, 4193, ENSG00000135679, HDMX, MGC71221, hdm2, Q00987
349 results:
1. Nanoencapsulation of mdm2 Inhibitor RG7388 and Class-I HDAC Inhibitor Entinostat Enhances their Therapeutic Potential Through Synergistic Antitumor Effects and Reduction of Systemic Toxicity.
Abed A; Greene MK; Alsa'd AA; Lees A; Hindley A; Longley DB; McDade SS; Scott CJ
Mol Pharm; 2024 Mar; 21(3):1246-1255. PubMed ID: 38334409
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2. Development and Nanoparticle-Mediated Delivery of Novel mdm2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in colorectal cancer Cells.
Merlino F; Pecoraro A; Longobardi G; Donati G; Di Leva FS; Brignola C; Piccarducci R; Daniele S; Martini C; Marinelli L; Russo G; Quaglia F; Conte C; Russo A; La Pietra V
J Med Chem; 2024 Feb; 67(3):1812-1824. PubMed ID: 38285632
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3. LC-HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies.
El-Hawary SS; Hassan MHA; Hudhud AO; Al-Karmalawy AA; Mustafa M; Hamed EAE; Abdelmohsen UR; Mohammed R
Chem Biodivers; 2024 Mar; 21(3):e202301617. PubMed ID: 38193652
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4. Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma.
Mohamed MF; Ibrahim NS; Saddiq AA; Abdelhamid IA
Sci Rep; 2023 Dec; 13(1):22486. PubMed ID: 38110432
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5. Characteristic Mutational Damages in Gastric and colorectal Adenocarcinomas.
Yermekova S; Orazgaliyeva M; Goncharova T; Rakhimbekova F; Kaidarova D; Shatkovskaya O
Asian Pac J Cancer Prev; 2023 Nov; 24(11):3939-3947. PubMed ID: 38019254
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6. Pathway-driven analysis of synthetic lethal interactions in cancer using perturbation screens.
Karimpour M; Totonchi M; Behmanesh M; Montazeri H
Life Sci Alliance; 2024 Jan; 7(1):. PubMed ID: 37863651
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7. CLDN6 inhibits colorectal cancer proliferation dependent on restraining p53 ubiquitination via ZO-1/PTEN axis.
Dong Y; Xu W; Qi D; Qu H; Jin Q; Sun M; Wang X; Quan C
Cell Signal; 2023 Dec; 112():110930. PubMed ID: 37852424
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8. New Schiff bases derived from dimethylpyridine-1,2,4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological evaluation and molecular docking studies.
Strzelecka M; Wiatrak B; Jawień P; Czyżnikowska Ż; Świątek P
Bioorg Chem; 2023 Oct; 139():106758. PubMed ID: 37540951
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9. Bilirubin, an endogenous antioxidant that affects p53 protein and its downstream apoptosis/autophagy-related genes in LS180 and SW480 cell culture models of colorectal cancer.
Niknam M; Maleki MH; Khakshournia S; Rasouli M; Vakili O; Shafiee SM
Biochem Biophys Res Commun; 2023 Sep; 672():161-167. PubMed ID: 37354609
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10. P53/mdm2 Complex-Based Targeted Strategies in Colon Adenocarcinoma.
Niotis A; Tsiambas E; Dimitroulis D; Sarlanis H; Falidas E; Kavantzas N; Constantinides CA
Acta Med Acad; 2023 Apr; 52(1):24-29. PubMed ID: 37326394
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11. The crosstalk between ubiquitin-conjugating enzyme E2Q1 and p53 in colorectal cancer: An in vitro analysis.
Rasouli M; Khakshournia S; Vakili O; Dastghaib S; Seghatoleslam A; Shafiee SM
Med Oncol; 2023 Jun; 40(7):199. PubMed ID: 37294480
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12. Spatial resolution of cellular senescence dynamics in human colorectal liver metastasis.
Garbarino O; Lambroia L; Basso G; Marrella V; Franceschini B; Soldani C; Pasqualini F; Giuliano D; Costa G; Peano C; Barbarossa D; Annarita D; Salvati A; Terracciano L; Torzilli G; Donadon M; Faggioli F
Aging Cell; 2023 Jul; 22(7):e13853. PubMed ID: 37157887
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13. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.
Xu B; Li Q; Zhang J; Chen F
Mol Oncol; 2023 Aug; 17(8):1678-1691. PubMed ID: 36931700
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14. Inclusion of Nitrofurantoin into the Realm of cancer Chemotherapy via Biology-Oriented Synthesis and Drug Repurposing.
Elzahhar PA; Nematalla HA; Al-Koussa H; Abrahamian C; El-Yazbi AF; Bodgi L; Bou-Gharios J; Azzi J; Al Choboq J; Labib HF; Kheir WA; Abu-Serie MM; Elrewiny MA; El-Yazbi AF; Belal ASF
J Med Chem; 2023 Apr; 66(7):4565-4587. PubMed ID: 36921275
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15. CopA3 peptide inhibits mdm2-p53 complex stability in colorectal cancers and activates p53 mediated cell death machinery.
Dey DK; Sharma C; Vadlamudi Y; Kang SC
Life Sci; 2023 Apr; 318():121476. PubMed ID: 36758667
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16. P-TEFb promotes cell survival upon p53 activation by suppressing intrinsic apoptosis pathway.
Wang Z; Mačáková M; Bugai A; Kuznetsov SG; Hassinen A; Lenasi T; Potdar S; Friedel CC; Barborič M
Nucleic Acids Res; 2023 Feb; 51(4):1687-1706. PubMed ID: 36727434
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17. A Reduction of Calcineurin Inhibitors May Improve Survival in Patients with De Novo colorectal cancer after Liver Transplantation.
Ossami Saidy RR; Wegener E; Uluk D; Dittrich L; Schöning W; Lurje G; Öllinger R; Modest DP; Tacke F; Haase O; Pratschke J; Eurich D
Medicina (Kaunas); 2022 Nov; 58(12):. PubMed ID: 36556957
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18. The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity.
Di Y; Jing X; Hu K; Wen X; Ye L; Zhang X; Qin J; Ye J; Lin R; Wang Z; He W
Drug Resist Updat; 2023 Jan; 66():100909. PubMed ID: 36525936
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19. Ononitol Monohydrate-A Glycoside Potentially Inhibit HT-115 Human colorectal cancer Cell Proliferation through COX-2/PGE-2 Inflammatory Axis Regulations.
Subash-Babu P; Aladel A; Almanaa TN; AlSedairy SA; Alshatwi AA
Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430918
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20. EXOSC8 promotes colorectal cancer tumorigenesis via regulating ribosome biogenesis-related processes.
Cui K; Gong L; Zhang H; Chen Y; Liu B; Gong Z; Li J; Wang Y; Sun S; Li Y; Zhang Q; Cao Y; Li Q; Fei B; Huang Z
Oncogene; 2022 Dec; 41(50):5397-5410. PubMed ID: 36348012
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