Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND MDM2, HDM2, 4193, ENSG00000135679, HDMX, MGC71221, hdm2, Q00987 AND Treatment
88 results:

  • 1. Development and Nanoparticle-Mediated Delivery of Novel mdm2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in colorectal cancer Cells.
    Merlino F; Pecoraro A; Longobardi G; Donati G; Di Leva FS; Brignola C; Piccarducci R; Daniele S; Martini C; Marinelli L; Russo G; Quaglia F; Conte C; Russo A; La Pietra V
    J Med Chem; 2024 Feb; 67(3):1812-1824. PubMed ID: 38285632
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. Characteristic Mutational Damages in Gastric and colorectal Adenocarcinomas.
    Yermekova S; Orazgaliyeva M; Goncharova T; Rakhimbekova F; Kaidarova D; Shatkovskaya O
    Asian Pac J Cancer Prev; 2023 Nov; 24(11):3939-3947. PubMed ID: 38019254
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.
    Xu B; Li Q; Zhang J; Chen F
    Mol Oncol; 2023 Aug; 17(8):1678-1691. PubMed ID: 36931700
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. A Reduction of Calcineurin Inhibitors May Improve Survival in Patients with De Novo colorectal cancer after Liver Transplantation.
    Ossami Saidy RR; Wegener E; Uluk D; Dittrich L; Schöning W; Lurje G; Öllinger R; Modest DP; Tacke F; Haase O; Pratschke J; Eurich D
    Medicina (Kaunas); 2022 Nov; 58(12):. PubMed ID: 36556957
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity.
    Di Y; Jing X; Hu K; Wen X; Ye L; Zhang X; Qin J; Ye J; Lin R; Wang Z; He W
    Drug Resist Updat; 2023 Jan; 66():100909. PubMed ID: 36525936
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Ononitol Monohydrate-A Glycoside Potentially Inhibit HT-115 Human colorectal cancer Cell Proliferation through COX-2/PGE-2 Inflammatory Axis Regulations.
    Subash-Babu P; Aladel A; Almanaa TN; AlSedairy SA; Alshatwi AA
    Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430918
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. Design of stapled peptide-based PROTACs for mdm2/MDMX atypical degradation and tumor suppression.
    Chen S; Li X; Li Y; Yuan X; Geng C; Gao S; Li J; Ma B; Wang Z; Lu W; Hu HG
    Theranostics; 2022; 12(15):6665-6681. PubMed ID: 36185610
    [No Abstract]    [Full Text] [Related]  

  • 8. A Rectal cancer Surgical Decision Aid Is Not Enough: A Qualitative Study.
    Goldwag JL; Saunders CH; Read JT; Durand MA; Elwyn G; Ivatury SJ
    Dis Colon Rectum; 2022 Dec; 65(12):1483-1493. PubMed ID: 36037408
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. p52-ZER6: a determinant of tumor cell sensitivity to mdm2-p53 binding inhibitors.
    Li WF; Alfason L; Huang C; Tang Y; Qiu L; Miyagishi M; Wu SR; Kasim V
    Acta Pharmacol Sin; 2023 Mar; 44(3):647-660. PubMed ID: 35995868
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by mdm2 inhibition in colorectal cancer.
    Yang L; WenTao T; ZhiYuan Z; Qi L; YuXiang L; Peng Z; Ke L; XiaoNa J; YuZhi P; MeiLing J; QingYang F; GuoDong H; YueXiang W; JianMin X
    Oncogene; 2022 Jun; 41(23):3210-3221. PubMed ID: 35505093
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. Discoidin domain receptor 1a (DDR1a) confers 5-fluorouracil cytotoxicity in LoVo cell via PI3K/AKT/Bcl-2 pathway.
    Xiong B; Song FX; Chen HL; Wang XJ; Jin ZX; Han TY; Li Y; Zhang DK
    Bioengineered; 2022 Apr; 13(4):9805-9814. PubMed ID: 35416117
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. Targeted β-catenin ubiquitination and degradation by multifunctional stapled peptides.
    Wang X; Dong L; Cheng J; Verdine GL; Lin A; Chu Q
    J Pept Sci; 2022 Jul; 28(7):e3389. PubMed ID: 34937123
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/mdm2 axis.
    Wang D; Wei X; Chen X; Wang Q; Zhang J; Kalvakolanu DV; Guo B; Zhang L
    Exp Cell Res; 2021 Oct; 407(1):112799. PubMed ID: 34461110
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. Rigosertib elicits potent anti-tumor responses in colorectal cancer by inhibiting Ras signaling pathway.
    Rahmani F; Hashemzehi M; Avan A; Barneh F; Asgharzadeh F; Moradi Marjaneh R; Soleimani A; Parizadeh M; Ferns GA; Ghayour Mobarhan M; Ryzhikov M; Afshari AR; Ahmadian MR; Giovannetti E; Jafari M; Khazaei M; Hassanian SM
    Cell Signal; 2021 Sep; 85():110069. PubMed ID: 34214591
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
    Chen J; Na R; Xiao C; Wang X; Wang Y; Yan D; Song G; Liu X; Chen J; Lu H; Chen C; Tang H; Zhuang G; Fan G; Peng Z
    Oncogene; 2021 Jun; 40(23):3974-3988. PubMed ID: 33990700
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo.
    Huang H; Park S; Zhang H; Park S; Kwon W; Kim E; Zhang X; Jang S; Yoon D; Choi SK; Yi JK; Kim SH; Dong Z; Lee MH; Ryoo Z; Kim MO
    J Exp Clin Cancer Res; 2021 Mar; 40(1):114. PubMed ID: 33785035
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Inhibition of mdm2 Promotes Antitumor Responses in p53 Wild-Type cancer Cells through Their Interaction with the Immune and Stromal Microenvironment.
    Wang HQ; Mulford IJ; Sharp F; Liang J; Kurtulus S; Trabucco G; Quinn DS; Longmire TA; Patel N; Patil R; Shirley MD; Chen Y; Wang H; Ruddy DA; Fabre C; Williams JA; Hammerman PS; Mataraza J; Platzer B; Halilovic E
    Cancer Res; 2021 Jun; 81(11):3079-3091. PubMed ID: 33504557
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. Chemopreventive Agent 3,3'-Diindolylmethane Inhibits mdm2 in colorectal cancer Cells.
    Gao X; Liu J; Cho KB; Kedika S; Guo B
    Int J Mol Sci; 2020 Jun; 21(13):. PubMed ID: 32629830
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. Transcatheter arterial infusion of anti-programmed cell death 1 antibody pembrolizumab combined with temozolomide or nab-paclitaxel in patient with primary anorectal malignant melanoma: Four case reports.
    Chen S; Zhang X; Shen L; Qi H; Ma W; Cao F; Xie L; Song Z; Wu Y; Li D; Wen X; Fan W
    J Cancer Res Ther; 2020; 16(2):387-392. PubMed ID: 32474528
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. Roles of DANCR/microRNA-518a-3p/MDMA ceRNA network in the growth and malignant behaviors of colon cancer cells.
    Sun Y; Cao B; Zhou J
    BMC Cancer; 2020 May; 20(1):434. PubMed ID: 32423468
    [TBL] [Abstract] [Full Text] [Related]  


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