Terms: = Colorectal cancer AND MDM2, HDM2, 4193, ENSG00000135679, HDMX, MGC71221, hdm2, Q00987 AND Treatment
90 results:
1. Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis).
Wang Z; Zhang X; Luo Y; Song Y; Xiang C; He Y; Wang K; Yu Y; Wang Z; Peng W; Ding Y; Liu S; Wu C
Cell Death Dis; 2024 May; 15(5):375. PubMed ID: 38811536
[TBL] [Abstract] [Full Text] [Related]
2. Helminth-derived molecules improve 5-fluorouracil treatment on experimental colon tumorigenesis.
Mendoza-Rodríguez MG; Medina-Reyes D; Sánchez-Barrera CA; Fernández-Muñoz KV; García-Castillo V; Ledesma-Torres JL; González-González MI; Reyes JL; Pérez-Plascencia C; Rodríguez-Sosa M; Vaca-Paniagua F; Meraz MA; Terrazas LI
Biomed Pharmacother; 2024 Jun; 175():116628. PubMed ID: 38663106
[TBL] [Abstract] [Full Text] [Related]
3. Development and Nanoparticle-Mediated Delivery of Novel mdm2/MDM4 Heterodimer Peptide Inhibitors to Enhance 5-Fluorouracil Nucleolar Stress in colorectal cancer Cells.
Merlino F; Pecoraro A; Longobardi G; Donati G; Di Leva FS; Brignola C; Piccarducci R; Daniele S; Martini C; Marinelli L; Russo G; Quaglia F; Conte C; Russo A; La Pietra V
J Med Chem; 2024 Feb; 67(3):1812-1824. PubMed ID: 38285632
[TBL] [Abstract] [Full Text] [Related]
4. Characteristic Mutational Damages in Gastric and colorectal Adenocarcinomas.
Yermekova S; Orazgaliyeva M; Goncharova T; Rakhimbekova F; Kaidarova D; Shatkovskaya O
Asian Pac J Cancer Prev; 2023 Nov; 24(11):3939-3947. PubMed ID: 38019254
[TBL] [Abstract] [Full Text] [Related]
5. LIM domain-containing protein Ajuba inhibits chemotherapy-induced apoptosis by negatively regulating p53 stability in colorectal cancer cells.
Xu B; Li Q; Zhang J; Chen F
Mol Oncol; 2023 Aug; 17(8):1678-1691. PubMed ID: 36931700
[TBL] [Abstract] [Full Text] [Related]
6. A Reduction of Calcineurin Inhibitors May Improve Survival in Patients with De Novo colorectal cancer after Liver Transplantation.
Ossami Saidy RR; Wegener E; Uluk D; Dittrich L; Schöning W; Lurje G; Öllinger R; Modest DP; Tacke F; Haase O; Pratschke J; Eurich D
Medicina (Kaunas); 2022 Nov; 58(12):. PubMed ID: 36556957
[TBL] [Abstract] [Full Text] [Related]
7. The c-MYC-WDR43 signalling axis promotes chemoresistance and tumour growth in colorectal cancer by inhibiting p53 activity.
Di Y; Jing X; Hu K; Wen X; Ye L; Zhang X; Qin J; Ye J; Lin R; Wang Z; He W
Drug Resist Updat; 2023 Jan; 66():100909. PubMed ID: 36525936
[TBL] [Abstract] [Full Text] [Related]
8. Ononitol Monohydrate-A Glycoside Potentially Inhibit HT-115 Human colorectal cancer Cell Proliferation through COX-2/PGE-2 Inflammatory Axis Regulations.
Subash-Babu P; Aladel A; Almanaa TN; AlSedairy SA; Alshatwi AA
Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430918
[TBL] [Abstract] [Full Text] [Related]
9. Design of stapled peptide-based PROTACs for mdm2/MDMX atypical degradation and tumor suppression.
Chen S; Li X; Li Y; Yuan X; Geng C; Gao S; Li J; Ma B; Wang Z; Lu W; Hu HG
Theranostics; 2022; 12(15):6665-6681. PubMed ID: 36185610
[No Abstract] [Full Text] [Related]
10. A Rectal cancer Surgical Decision Aid Is Not Enough: A Qualitative Study.
Goldwag JL; Saunders CH; Read JT; Durand MA; Elwyn G; Ivatury SJ
Dis Colon Rectum; 2022 Dec; 65(12):1483-1493. PubMed ID: 36037408
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11. p52-ZER6: a determinant of tumor cell sensitivity to mdm2-p53 binding inhibitors.
Li WF; Alfason L; Huang C; Tang Y; Qiu L; Miyagishi M; Wu SR; Kasim V
Acta Pharmacol Sin; 2023 Mar; 44(3):647-660. PubMed ID: 35995868
[TBL] [Abstract] [Full Text] [Related]
12. Cullin-9/p53 mediates HNRNPC degradation to inhibit erastin-induced ferroptosis and is blocked by mdm2 inhibition in colorectal cancer.
Yang L; WenTao T; ZhiYuan Z; Qi L; YuXiang L; Peng Z; Ke L; XiaoNa J; YuZhi P; MeiLing J; QingYang F; GuoDong H; YueXiang W; JianMin X
Oncogene; 2022 Jun; 41(23):3210-3221. PubMed ID: 35505093
[TBL] [Abstract] [Full Text] [Related]
13. Discoidin domain receptor 1a (DDR1a) confers 5-fluorouracil cytotoxicity in LoVo cell via PI3K/AKT/Bcl-2 pathway.
Xiong B; Song FX; Chen HL; Wang XJ; Jin ZX; Han TY; Li Y; Zhang DK
Bioengineered; 2022 Apr; 13(4):9805-9814. PubMed ID: 35416117
[TBL] [Abstract] [Full Text] [Related]
14. Targeted β-catenin ubiquitination and degradation by multifunctional stapled peptides.
Wang X; Dong L; Cheng J; Verdine GL; Lin A; Chu Q
J Pept Sci; 2022 Jul; 28(7):e3389. PubMed ID: 34937123
[TBL] [Abstract] [Full Text] [Related]
15. GRIM-19 inhibits proliferation and induces apoptosis in a p53-dependent manner in colorectal cancer cells through the SIRT7/PCAF/mdm2 axis.
Wang D; Wei X; Chen X; Wang Q; Zhang J; Kalvakolanu DV; Guo B; Zhang L
Exp Cell Res; 2021 Oct; 407(1):112799. PubMed ID: 34461110
[TBL] [Abstract] [Full Text] [Related]
16. Rigosertib elicits potent anti-tumor responses in colorectal cancer by inhibiting Ras signaling pathway.
Rahmani F; Hashemzehi M; Avan A; Barneh F; Asgharzadeh F; Moradi Marjaneh R; Soleimani A; Parizadeh M; Ferns GA; Ghayour Mobarhan M; Ryzhikov M; Afshari AR; Ahmadian MR; Giovannetti E; Jafari M; Khazaei M; Hassanian SM
Cell Signal; 2021 Sep; 85():110069. PubMed ID: 34214591
[TBL] [Abstract] [Full Text] [Related]
17. The loss of SHMT2 mediates 5-fluorouracil chemoresistance in colorectal cancer by upregulating autophagy.
Chen J; Na R; Xiao C; Wang X; Wang Y; Yan D; Song G; Liu X; Chen J; Lu H; Chen C; Tang H; Zhuang G; Fan G; Peng Z
Oncogene; 2021 Jun; 40(23):3974-3988. PubMed ID: 33990700
[TBL] [Abstract] [Full Text] [Related]
18. Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo.
Huang H; Park S; Zhang H; Park S; Kwon W; Kim E; Zhang X; Jang S; Yoon D; Choi SK; Yi JK; Kim SH; Dong Z; Lee MH; Ryoo Z; Kim MO
J Exp Clin Cancer Res; 2021 Mar; 40(1):114. PubMed ID: 33785035
[TBL] [Abstract] [Full Text] [Related]
19. Inhibition of mdm2 Promotes Antitumor Responses in p53 Wild-Type cancer Cells through Their Interaction with the Immune and Stromal Microenvironment.
Wang HQ; Mulford IJ; Sharp F; Liang J; Kurtulus S; Trabucco G; Quinn DS; Longmire TA; Patel N; Patil R; Shirley MD; Chen Y; Wang H; Ruddy DA; Fabre C; Williams JA; Hammerman PS; Mataraza J; Platzer B; Halilovic E
Cancer Res; 2021 Jun; 81(11):3079-3091. PubMed ID: 33504557
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20. Chemopreventive Agent 3,3'-Diindolylmethane Inhibits mdm2 in colorectal cancer Cells.
Gao X; Liu J; Cho KB; Kedika S; Guo B
Int J Mol Sci; 2020 Jun; 21(13):. PubMed ID: 32629830
[TBL] [Abstract] [Full Text] [Related]
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