Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND NT5C2, ENSG00000076685, 22978, P49902, PNT5, NT5B, GMP, cN-II AND Treatment
29 results:

  • 1. Wnt/β-catenin signalling activates IMPDH2-mediated purine metabolism to facilitate oxaliplatin resistance by inhibiting caspase-dependent apoptosis in colorectal cancer.
    Huang Y; Chan S; Chen S; Liu X; Li M; Zheng L; Dong Z; Yang Z; Liu Z; Zhou D; Zhang X; Zhang B
    J Transl Med; 2024 Feb; 22(1):133. PubMed ID: 38310229
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation.
    Chen B; Hong Y; Zhai X; Deng Y; Hu H; Tian S; Zhang Y; Ren X; Zhao J; Jiang C
    Cell Death Dis; 2023 Dec; 14(12):809. PubMed ID: 38065948
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. Activatable Mn
    Liang Q; Chen J; Hou S; Li D; Zhu Y; Li R; Chen L; Li J; Fu W; Lei S; Zhang B; Zheng X; Zhang T; Duan H; He W; Ren J
    Biomaterials; 2023 Sep; 300():122206. PubMed ID: 37348325
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity.
    Fang L; Hao Y; Yu H; Gu X; Peng Q; Zhuo H; Li Y; Liu Z; Wang J; Chen Y; Zhang J; Tian H; Gao Y; Gao R; Teng H; Shan Z; Zhu J; Li Z; Liu Y; Zhang Y; Yu F; Lin Z; Hao Y; Ge X; Yuan J; Hu HG; Ma Y; Qin HL; Wang P
    Cancer Cell; 2023 Jun; 41(6):1118-1133.e12. PubMed ID: 37267951
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. An optimized IgG-based B7-H3xCD3 bispecific antibody for treatment of gastrointestinal cancers.
    Zekri L; Lutz M; Prakash N; Manz T; Klimovich B; Mueller S; Hoerner S; Hagelstein I; Engel M; Chashchina A; Pfluegler M; Heitmann JS; Jung G; Salih HR
    Mol Ther; 2023 Apr; 31(4):1033-1045. PubMed ID: 36793213
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Generation of colon cancer-derived tumor-infiltrating T cells (TILs) for adoptive cell therapy.
    Albrecht HC; Gustavus D; Schwanemann J; Dammermann W; Lippek F; Weylandt KH; Hoffmeister H; Gretschel S
    Cytotherapy; 2023 May; 25(5):537-547. PubMed ID: 36775787
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. PARPi treatment enhances radiotherapy-induced ferroptosis and antitumor immune responses via the cGAS signaling pathway in colorectal cancer.
    Shen D; Luo J; Chen L; Ma W; Mao X; Zhang Y; Zheng J; Wang Y; Wan J; Wang S; Ouyang J; Yi H; Liu D; Huang W; Zhang W; Liu Z; McLeod HL; He Y
    Cancer Lett; 2022 Dec; 550():215919. PubMed ID: 36116741
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. Genetic variants involved in the cGAS-STING pathway predict outcome in patients with metastatic colorectal cancer: Data from FIRE-3 and TRIBE trials.
    Wang J; Xiao Y; Loupakis F; Stintzing S; Yang Y; Arai H; Battaglin F; Kawanishi N; Jayachandran P; Soni S; Zhang W; Mancao C; Cremolini C; Liu T; Heinemann V; Falcone A; Shen L; Millstein J; Lenz HJ
    Eur J Cancer; 2022 Sep; 172():22-30. PubMed ID: 35749909
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. cGAS-STING signaling pathway in gastrointestinal inflammatory disease and cancers.
    Ke X; Hu T; Jiang M
    FASEB J; 2022 Jan; 36(1):e22029. PubMed ID: 34907606
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon cancer.
    Wei B; Xu L; Guo W; Wang Y; Wu J; Li X; Cai X; Hu J; Wang M; Xu Q; Liu W; Gu Y
    Cancer Res; 2021 Jun; 81(12):3215-3228. PubMed ID: 33820798
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer.
    Li Y; Sun Z; Cui Y; Zhang H; Zhang S; Wang X; Liu S; Gao Q
    Bioorg Chem; 2021 Feb; 107():104636. PubMed ID: 33465670
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. The design and characterization of a gravitational microfluidic platform for drug sensitivity assay in colorectal perfused tumoroid cultures.
    Wang T; Green R; Howell M; Martinez T; Dutta R; Mohapatra S; Mohapatra SS
    Nanomedicine; 2020 Nov; 30():102294. PubMed ID: 32861031
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. Targeting the paracrine hormone-dependent guanylate cyclase/cgmp/phosphodiesterases signaling pathway for colorectal cancer prevention.
    Yarla NS; Gali H; Pathuri G; Smriti S; Farooqui M; Panneerselvam J; Kumar G; Madka V; Rao CV
    Semin Cancer Biol; 2019 Jun; 56():168-174. PubMed ID: 30189250
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders.
    Waldman SA; Camilleri M
    Gut; 2018 Aug; 67(8):1543-1552. PubMed ID: 29563144
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. Phosphodiesterases in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia.
    Mahmood B; Damm MM; Jensen TS; Backe MB; Dahllöf MS; Poulsen SS; Bindslev N; Hansen MB
    BMC Cancer; 2016 Dec; 16(1):938. PubMed ID: 27927168
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Cross talk between receptor guanylyl cyclase C and c-src tyrosine kinase regulates colon cancer cell cytostasis.
    Basu N; Bhandari R; Natarajan VT; Visweswariah SS
    Mol Cell Biol; 2009 Oct; 29(19):5277-89. PubMed ID: 19620276
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Four peptides decrease human colon adenocarcinoma cell number and DNA synthesis via cyclic gmp.
    Gower WR; Vesely BA; Alli AA; Vesely DL
    Int J Gastrointest Cancer; 2005; 36(2):77-87. PubMed ID: 16648657
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. Sulindac independently modulates extracellular signal-regulated kinase 1/2 and cyclic gmp-dependent protein kinase signaling pathways.
    Rice PL; Peters SL; Beard KS; Ahnen DJ
    Mol Cancer Ther; 2006 Mar; 5(3):746-54. PubMed ID: 16546990
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.
    Deguchi A; Xing SW; Shureiqi I; Yang P; Newman RA; Lippman SM; Feinmark SJ; Oehlen B; Weinstein IB
    Cancer Res; 2005 Sep; 65(18):8442-7. PubMed ID: 16166323
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. 3',5'-Cyclic diguanylic acid (c-di-gmp) inhibits basal and growth factor-stimulated human colon cancer cell proliferation.
    Karaolis DK; Cheng K; Lipsky M; Elnabawi A; Catalano J; Hyodo M; Hayakawa Y; Raufman JP
    Biochem Biophys Res Commun; 2005 Apr; 329(1):40-5. PubMed ID: 15721270
    [TBL] [Abstract] [Full Text] [Related]  


    of 2.