Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND STK11, LKB1, 6794, ENSG00000118046, Q15831, PJS AND Treatment
34 results:

  • 1. Phase I Study of mTORC1/2 Inhibitor Sapanisertib (CB-228/TAK-228) in Combination with Metformin in Patients with mTOR/AKT/PI3K Pathway Alterations and Advanced Solid Malignancies.
    Subbiah V; Coleman N; Piha-Paul SA; Tsimberidou AM; Janku F; Rodon J; Pant S; Dumbrava EEI; Fu S; Hong DS; Zhang S; Sun M; Jiang Y; Roszik J; Song J; Yuan Y; Meric-Bernstam F; Naing A
    Cancer Res Commun; 2024 Feb; 4(2):378-387. PubMed ID: 38126764
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. Clinical Characteristics and Responses to Immune Checkpoint Inhibitors in RET-Aberrant Digestive Tract Tumours.
    Yen CC; Yeh YM; Huang HY; Ting YL; Fu PA; Lin TC; Liu IT; Yen CJ
    Target Oncol; 2023 Jul; 18(4):611-623. PubMed ID: 37347391
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. Celastrol as an emerging anticancer agent: Current status, challenges and therapeutic strategies.
    Wang C; Dai S; Zhao X; Zhang Y; Gong L; Fu K; Ma C; Peng C; Li Y
    Biomed Pharmacother; 2023 Jul; 163():114882. PubMed ID: 37196541
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Strong Hereditary Predispositions to colorectal cancer.
    Hryhorowicz S; Kaczmarek-Ryś M; Lis-Tanaś E; Porowski J; Szuman M; Grot N; Kryszczyńska A; Paszkowski J; Banasiewicz T; Pławski A
    Genes (Basel); 2022 Dec; 13(12):. PubMed ID: 36553592
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. Pancreatic cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation.
    Vietri MT; D'Elia G; Caliendo G; Albanese L; Signoriello G; Napoli C; Molinari AM
    Genes (Basel); 2022 Feb; 13(2):. PubMed ID: 35205366
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Molecular characteristics of young-onset colorectal cancer in Vietnamese patients.
    Do MD; Nguyen TH; Le KT; Le LHG; Nguyen BH; Le KT; Doan TPT; Ho CQ; Nguyen HN; Tran TD; Vu HA
    Asia Pac J Clin Oncol; 2022 Dec; 18(6):678-685. PubMed ID: 35098669
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. 30 year experience of index case identification and outcomes of cascade testing in high-risk breast and colorectal cancer predisposition genes.
    Woodward ER; Green K; Burghel GJ; Bulman M; Clancy T; Lalloo F; Schlecht H; Wallace AJ; Evans DG
    Eur J Hum Genet; 2022 Apr; 30(4):413-419. PubMed ID: 34866136
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. Genomic characterization of hepatoid tumors: context matters.
    Lawlor RT; Mafficini A; Sciammarella C; Cantù C; Rusev BC; Piredda ML; Antonello D; Grimaldi S; Bonizzato G; Sperandio N; Marchegiani G; Malleo G; Pea A; Salvia R; Mombello A; Mazzoleni G; Nottegar A; Hanspeter E; Riva G; Tomezzoli A; Bencivenga M; de Manzoni G; Pedron S; Paolino G; Mattiolo P; Brosens LA; Silvestris N; Fassan M; Cooke SL; Beer PA; Milella M; Adsay VN; Cheng L; Scarpa A; Luchini C
    Hum Pathol; 2021 Dec; 118():30-41. PubMed ID: 34562502
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. The influence of stk11 mutation on acquired resistance to immunotherapy in advanced non-small cell lung cancer with Lynch syndrome: a case report and literature review.
    Long Y; Tang Y; Cai C; Yu M; Zhang M; Chen R; Huang M
    Ann Palliat Med; 2021 Jun; 10(6):7088-7094. PubMed ID: 33832284
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. A prospective multicenter phase II study on the efficacy and safety of dasatinib in the treatment of metastatic gastrointestinal stromal tumors failed by imatinib and sunitinib and analysis of NGS in peripheral blood.
    Zhou Y; Zhang X; Wu X; Zhou Y; Zhang B; Liu X; Wu X; Li Y; Shen L; Li J
    Cancer Med; 2020 Sep; 9(17):6225-6233. PubMed ID: 32677196
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. A Phase IIa Trial of Metformin for colorectal cancer Risk Reduction among Individuals with History of colorectal Adenomas and Elevated Body Mass Index.
    Zell JA; McLaren CE; Morgan TR; Lawson MJ; Rezk S; Albers CG; Chen WP; Carmichael JC; Chung J; Richmond E; Rodriguez LM; Szabo E; Ford LG; Pollak MN; Meyskens FL
    Cancer Prev Res (Phila); 2020 Feb; 13(2):203-212. PubMed ID: 31818851
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. MCT1 relieves osimertinib-induced CRC suppression by promoting autophagy through the lkb1/AMPK signaling.
    Jin P; Jiang J; Xie N; Zhou L; Huang Z; Zhang L; Qin S; Fu S; Peng L; Gao W; Li B; Lei Y; Nice EC; Li C; Shao J; Xie K
    Cell Death Dis; 2019 Aug; 10(8):615. PubMed ID: 31409796
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis.
    Xu YH; Song QQ; Li C; Hu YT; Song BB; Ye JM; Rao Y; Huang ZS
    Eur J Pharmacol; 2019 Jul; 854():328-337. PubMed ID: 31028741
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. [Diagnosis and treatment for 46 cases of Peutz-Jeghers syndrome].
    Jia Y; Fu H; Li N; Kang Q; Sheng J
    Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2018 Dec; 43(12):1323-1327. PubMed ID: 30643048
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. Clinical significance of multiple gene detection with a 22-gene panel in formalin-fixed paraffin-embedded specimens of 207 colorectal cancer patients.
    Gao XH; Yu GY; Hong YG; Lian W; Chouhan H; Xu Y; Liu LJ; Bai CG; Zhang W
    Int J Clin Oncol; 2019 Feb; 24(2):141-152. PubMed ID: 30612269
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Sodium butyrate induces autophagy in colorectal cancer cells through lkb1/AMPK signaling.
    Luo S; Li Z; Mao L; Chen S; Sun S
    J Physiol Biochem; 2019 Feb; 75(1):53-63. PubMed ID: 30362049
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer.
    Chen GQ; Gong RH; Yang DJ; Zhang G; Lu AP; Yan SC; Lin SH; Bian ZX
    Cell Death Dis; 2017 May; 8(5):e2789. PubMed ID: 28492544
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. Laparoscopic restorative proctocolectomy with ileal pouch-anal anastomosis for Peutz-Jeghers syndrome with synchronous rectal cancer.
    Zhong ME; Niu BZ; Ji WY; Wu B
    World J Gastroenterol; 2016 Jun; 22(22):5293-6. PubMed ID: 27298573
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. [Rare hereditary syndromes associated with polyposis and the development of malignant tumors].
    Kazubskaya TP; Kozlova VM; Filippova MG; Тrofimov EI; Belev NF; Sokolova IN; Tamrazov RI; Pavlovskaya AI; Kondratyeva TT
    Arkh Patol; 2016; 78(2):10-18. PubMed ID: 27070770
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. Clinical features, endoscopic polypectomy and stk11 gene mutation in a nine-month-old Peutz-Jeghers syndrome Chinese infant.
    Huang ZH; Song Z; Zhang P; Wu J; Huang Y
    World J Gastroenterol; 2016 Mar; 22(11):3261-7. PubMed ID: 27004004
    [TBL] [Abstract] [Full Text] [Related]  


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