Terms: = Colorectal cancer AND WRN, RECQL2, 7486, ENSG00000165392, Q14191, RECQ3
41 results:
1. Discovery of wrn inhibitor HRO761 with synthetic lethality in MSI cancers.
Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
[TBL] [Abstract] [Full Text] [Related]
2. Chemoproteomic discovery of a covalent allosteric inhibitor of wrn helicase.
Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
[TBL] [Abstract] [Full Text] [Related]
3. Discovering potential wrn inhibitors from natural product database through computational methods.
Jiang T; Zhang Y; Yu S; Hu B
J Mol Graph Model; 2024 Jun; 129():108758. PubMed ID: 38507856
[TBL] [Abstract] [Full Text] [Related]
4. wrn Is a Promising Synthetic Lethal Target for cancers with Microsatellite Instability (MSI).
Chan EM; Foster KJ; Bass AJ
Cancer Treat Res; 2023; 186():313-328. PubMed ID: 37978143
[TBL] [Abstract] [Full Text] [Related]
5. Senescence risk score: a multifaceted prognostic tool predicting outcomes, stemness, and immune responses in colorectal cancer.
Zhang X; Huang Y; Li Q; Zhong Y; Zhang Y; Hu J; Liu R; Luo X
Front Immunol; 2023; 14():1265911. PubMed ID: 37828981
[TBL] [Abstract] [Full Text] [Related]
6. Co-Occurrence of Germline Genomic Variants and Copy Number Variations in Hereditary Breast and colorectal cancer Patients.
Côrtes L; Basso TR; Villacis RAR; Souza JDS; Jørgensen MMA; Achatz MI; Rogatto SR
Genes (Basel); 2023 Aug; 14(8):. PubMed ID: 37628631
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7. Germline cancer Gene Expression Quantitative Trait Loci Are Associated with Local and Global Tumor Mutations.
Liu Y; Gusev A; Kraft P
Cancer Res; 2023 Apr; 83(8):1191-1202. PubMed ID: 36745477
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8. Racial/Ethnic and Sex Differences in Somatic cancer Gene Mutations among Patients with Early-Onset colorectal cancer.
Holowatyj AN; Wen W; Gibbs T; Seagle HM; Keller SR; Edwards DRV; Washington MK; Eng C; Perea J; Zheng W; Guo X
Cancer Discov; 2023 Mar; 13(3):570-579. PubMed ID: 36520636
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9. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
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10. Sensitivities and Dependencies of
Voutsadakis IA
Medicina (Kaunas); 2022 Oct; 58(10):. PubMed ID: 36295658
[No Abstract] [Full Text] [Related]
11. Provider preferences for anal cancer prevention screening: Results of the International Anal Neoplasia Society survey.
Plotzker RE; Barnell GM; Wiley DJ; Stier EA; Jay N
Tumour Virus Res; 2022 Jun; 13():200235. PubMed ID: 35183808
[TBL] [Abstract] [Full Text] [Related]
12. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient colorectal cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
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13. The effect of vitamin D on the occurrence and development of colorectal cancer: a systematic review and meta-analysis.
Xu Y; Qian M; Hong J; Ng DM; Yang T; Xu L; Ye X
Int J Colorectal Dis; 2021 Jul; 36(7):1329-1344. PubMed ID: 33598751
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14. Endoscopic submucosal dissection for colorectal lesions: outcomes from a United States experience.
Gupta N; Rodríguez-Ruiz G; Siddiqui UD; Chapman CG; Donboli K; Hart J; Xiao SY; Waxman I
Surg Endosc; 2022 Jan; 36(1):236-243. PubMed ID: 33523276
[TBL] [Abstract] [Full Text] [Related]
15. Revealing the Potential Application of EC-Synthetic Retinoid Analogues in Anticancer Therapy.
Abdelaal MR; Soror SH; Elnagar MR; Haffez H
Molecules; 2021 Jan; 26(2):. PubMed ID: 33477997
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16. Structure of the helicase core of Werner helicase, a key target in microsatellite instability cancers.
Newman JA; Gavard AE; Lieb S; Ravichandran MC; Hauer K; Werni P; Geist L; Böttcher J; Engen JR; Rumpel K; Samwer M; Petronczki M; Gileadi O
Life Sci Alliance; 2021 Jan; 4(1):. PubMed ID: 33199508
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17. Prevalence of APC and PTEN Alterations in Urachal cancer.
Nagy N; Reis H; Hadaschik B; Niedworok C; Módos O; Szendrői A; Bíró K; Hager T; Herold T; Ablat J; Black PC; Okon K; Tolkach Y; Csizmarik A; Oláh C; Keresztes D; Bremmer F; Gaisa NT; Kriegsmann J; Kovalszky I; Kiss A; Tímár J; Szász MA; Rink M; Fisch M; Nyirády P; Szarvas T
Pathol Oncol Res; 2020 Oct; 26(4):2773-2781. PubMed ID: 32754865
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18. Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in colorectal cancer.
Lazzari L; Corti G; Picco G; Isella C; Montone M; Arcella P; Durinikova E; Zanella ER; Novara L; Barbosa F; Cassingena A; Cancelliere C; Medico E; Sartore-Bianchi A; Siena S; Garnett MJ; Bertotti A; Trusolino L; Di Nicolantonio F; Linnebacher M; Bardelli A; Arena S
Clin Cancer Res; 2019 Oct; 25(20):6243-6259. PubMed ID: 31375513
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19. Werner syndrome helicase is a selective vulnerability of microsatellite instability-high tumor cells.
Lieb S; Blaha-Ostermann S; Kamper E; Rippka J; Schwarz C; Ehrenhöfer-Wölfer K; Schlattl A; Wernitznig A; Lipp JJ; Nagasaka K; van der Lelij P; Bader G; Koi M; Goel A; Neumüller RA; Peters JM; Kraut N; Pearson MA; Petronczki M; Wöhrle S
Elife; 2019 Mar; 8():. PubMed ID: 30910006
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20. Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic colorectal cancer.
Cha Y; Kim SY; Yeo HY; Baek JY; Choi MK; Jung KH; Dong SM; Chang HJ
Neoplasia; 2019 Jan; 21(1):146-155. PubMed ID: 30562637
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