Terms: = Colorectal cancer AND WRN, RECQL2, 7486, ENSG00000165392, Q14191, RECQ3 AND Treatment
11 results:
1. Discovery of wrn inhibitor HRO761 with synthetic lethality in MSI cancers.
Ferretti S; Hamon J; de Kanter R; Scheufler C; Andraos-Rey R; Barbe S; Bechter E; Blank J; Bordas V; Dammassa E; Decker A; Di Nanni N; Dourdoigne M; Gavioli E; Hattenberger M; Heuser A; Hemmerlin C; Hinrichs J; Kerr G; Laborde L; Jaco I; Núñez EJ; Martus HJ; Quadt C; Reschke M; Romanet V; Schaeffer F; Schoepfer J; Schrapp M; Strang R; Voshol H; Wartmann M; Welly S; Zécri F; Hofmann F; Möbitz H; Cortés-Cros M
Nature; 2024 May; 629(8011):443-449. PubMed ID: 38658754
[TBL] [Abstract] [Full Text] [Related]
2. Chemoproteomic discovery of a covalent allosteric inhibitor of wrn helicase.
Baltgalvis KA; Lamb KN; Symons KT; Wu CC; Hoffman MA; Snead AN; Song X; Glaza T; Kikuchi S; Green JC; Rogness DC; Lam B; Rodriguez-Aguirre ME; Woody DR; Eissler CL; Rodiles S; Negron SM; Bernard SM; Tran E; Pollock J; Tabatabaei A; Contreras V; Williams HN; Pastuszka MK; Sigler JJ; Pettazzoni P; Rudolph MG; Classen M; Brugger D; Claiborne C; Plancher JM; Cuartas I; Seoane J; Burgess LE; Abraham RT; Weinstein DS; Simon GM; Patricelli MP; Kinsella TM
Nature; 2024 May; 629(8011):435-442. PubMed ID: 38658751
[TBL] [Abstract] [Full Text] [Related]
3. Senescence risk score: a multifaceted prognostic tool predicting outcomes, stemness, and immune responses in colorectal cancer.
Zhang X; Huang Y; Li Q; Zhong Y; Zhang Y; Hu J; Liu R; Luo X
Front Immunol; 2023; 14():1265911. PubMed ID: 37828981
[TBL] [Abstract] [Full Text] [Related]
4. Germline cancer Gene Expression Quantitative Trait Loci Are Associated with Local and Global Tumor Mutations.
Liu Y; Gusev A; Kraft P
Cancer Res; 2023 Apr; 83(8):1191-1202. PubMed ID: 36745477
[TBL] [Abstract] [Full Text] [Related]
5. Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer.
Hao S; Tong J; Jha A; Risnik D; Lizardo D; Lu X; Goel A; Opresko PL; Yu J; Zhang L
Proc Natl Acad Sci U S A; 2022 Dec; 119(51):e2211775119. PubMed ID: 36508676
[TBL] [Abstract] [Full Text] [Related]
6. Werner Helicase Is a Synthetic-Lethal Vulnerability in Mismatch Repair-Deficient colorectal cancer Refractory to Targeted Therapies, Chemotherapy, and Immunotherapy.
Picco G; Cattaneo CM; van Vliet EJ; Crisafulli G; Rospo G; Consonni S; Vieira SF; Rodríguez IS; Cancelliere C; Banerjee R; Schipper LJ; Oddo D; Dijkstra KK; Cinatl J; Michaelis M; Yang F; Di Nicolantonio F; Sartore-Bianchi A; Siena S; Arena S; Voest EE; Bardelli A; Garnett MJ;
Cancer Discov; 2021 Aug; 11(8):1923-1937. PubMed ID: 33837064
[TBL] [Abstract] [Full Text] [Related]
7. Association of CHFR Promoter Methylation with treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic colorectal cancer.
Cha Y; Kim SY; Yeo HY; Baek JY; Choi MK; Jung KH; Dong SM; Chang HJ
Neoplasia; 2019 Jan; 21(1):146-155. PubMed ID: 30562637
[TBL] [Abstract] [Full Text] [Related]
8. Genetic Variants That Predispose to DNA Double-Strand Breaks in Lymphocytes From a Subset of Patients With Familial colorectal Carcinomas.
Arora S; Yan H; Cho I; Fan HY; Luo B; Gai X; Bodian DL; Vockley JG; Zhou Y; Handorf EA; Egleston BL; Andrake MD; Nicolas E; Serebriiskii IG; Yen TJ; Hall MJ; Golemis EA; Enders GH
Gastroenterology; 2015 Dec; 149(7):1872-1883.e9. PubMed ID: 26344056
[TBL] [Abstract] [Full Text] [Related]
9. Epigenetic drivers of genetic alterations.
Toyota M; Suzuki H
Adv Genet; 2010; 70():309-23. PubMed ID: 20920753
[TBL] [Abstract] [Full Text] [Related]
10. CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.
Ogino S; Meyerhardt JA; Kawasaki T; Clark JW; Ryan DP; Kulke MH; Enzinger PC; Wolpin BM; Loda M; Fuchs CS
Virchows Arch; 2007 May; 450(5):529-37. PubMed ID: 17372756
[TBL] [Abstract] [Full Text] [Related]
11. Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.
Agrelo R; Cheng WH; Setien F; Ropero S; Espada J; Fraga MF; Herranz M; Paz MF; Sanchez-Cespedes M; Artiga MJ; Guerrero D; Castells A; von Kobbe C; Bohr VA; Esteller M
Proc Natl Acad Sci U S A; 2006 Jun; 103(23):8822-7. PubMed ID: 16723399
[TBL] [Abstract] [Full Text] [Related]
