Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND XPO1, DKFZp686B1823, 7514, ENSG00000082898, O14980, CRM1
25 results:

  • 1. Discovery of Aminoratjadone Derivatives as Potent Noncovalent crm1 Inhibitors.
    Jian L; Zscherp R; Beutling U; Shen X; Xu S; Zhang X; Brönstrup M; Klahn P; Sun Q
    J Med Chem; 2023 Sep; 66(17):11940-11950. PubMed ID: 37595020
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. Nuclear export of BATF2 enhances colorectal cancer proliferation through binding to crm1.
    Zhou J; Lei Z; Chen J; Liao S; Chen Y; Liu C; Huang S; Li L; Zhang Y; Wang P; Huang Y; Li J; Liang H
    Clin Transl Med; 2023 May; 13(5):e1260. PubMed ID: 37151195
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. O-GlcNAcylation promotes the cytosolic localization of the m
    Li J; Ahmad M; Sang L; Zhan Y; Wang Y; Yan Y; Liu Y; Mi W; Lu M; Dai Y; Zhang R; Dong MQ; Yang YG; Wang X; Sun J; Li J
    J Biol Chem; 2023 Jun; 299(6):104738. PubMed ID: 37086786
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study.
    Wang J; Xiu J; Farrell A; Baca Y; Arai H; Battaglin F; Kawanishi N; Soni S; Zhang W; Millstein J; Shields AF; Grothey A; Weinberg BA; Marshall JL; Lou E; Khushman M; Sohal DPS; Hall MJ; Liu T; Oberley M; Spetzler D; Korn WM; Shen L; Lenz HJ
    Lancet Oncol; 2023 Feb; 24(2):151-161. PubMed ID: 36681091
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. Sequential Administration of xpo1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated colorectal cancer.
    Inoue A; Robinson FS; Minelli R; Tomihara H; Rizi BS; Rose JL; Kodama T; Srinivasan S; Harris AL; Zuniga AM; Mullinax RA; Ma X; Seth S; Daniele JR; Peoples MD; Loponte S; Akdemir KC; Khor TO; Feng N; Roszik J; Sobieski MM; Brunell D; Stephan C; Giuliani V; Deem AK; Shingu T; Deribe YL; Menter DG; Heffernan TP; Viale A; Bristow CA; Kopetz S; Draetta GF; Genovese G; Carugo A
    Gastroenterology; 2021 Jul; 161(1):196-210. PubMed ID: 33745946
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Association of xpo1 Overexpression with NF-κB and Ki67 in colorectal cancer.
    Aladhraei M; Kassem Al-Thobhani A; Poungvarin N; Suwannalert P
    Asian Pac J Cancer Prev; 2019 Dec; 20(12):3747-3754. PubMed ID: 31870117
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
    Fang L; Teng H; Wang Y; Liao G; Weng L; Li Y; Wang X; Jin J; Jiao C; Chen L; Peng X; Chen J; Yang Y; Fang H; Han D; Li C; Jin X; Zhang S; Liu Z; Liu M; Wei Q; Liao L; Ge X; Zhao B; Zhou D; Qin HL; Zhou J; Wang P
    Cancer Cell; 2018 Jul; 34(1):103-118.e9. PubMed ID: 30008322
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. MicroRNA-192-5p is a predictive biomarker of survival for Stage IIIB colon cancer patients.
    Li P; Ou Q; Braciak TA; Chen G; Oduncu FS
    Jpn J Clin Oncol; 2018 Jul; 48(7):619-624. PubMed ID: 29529220
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. Nuclear Export of Ubiquitinated Proteins Determines the Sensitivity of colorectal cancer to Proteasome Inhibitor.
    Wu T; Chen W; Zhong Y; Hou X; Fang S; Liu CY; Wang G; Yu T; Huang YY; Ouyang X; Li HQ; Cui L; Yang Y
    Mol Cancer Ther; 2017 Apr; 16(4):717-728. PubMed ID: 27903750
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. First-line treatment with FOLFOXIRI for advanced pancreatic cancer in clinical practice: Patients' outcome and analysis of prognostic factors.
    Vivaldi C; Caparello C; Musettini G; Pasquini G; Catanese S; Fornaro L; Lencioni M; Falcone A; Vasile E
    Int J Cancer; 2016 Aug; 139(4):938-45. PubMed ID: 27038273
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4.
    Lin PL; Chang JT; Wu DW; Huang CC; Lee H
    Free Radic Biol Med; 2016 Jun; 95():121-32. PubMed ID: 27033953
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. xpo1 Inhibition Enhances Radiation Response in Preclinical Models of Rectal cancer.
    Ferreiro-Neira I; Torres NE; Liesenfeld LF; Chan CH; Penson T; Landesman Y; Senapedis W; Shacham S; Hong TS; Cusack JC
    Clin Cancer Res; 2016 Apr; 22(7):1663-73. PubMed ID: 26603256
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. Novel reversible selective inhibitor of nuclear export shows that crm1 is a target in colorectal cancer cells.
    Niu M; Chong Y; Han Y; Liu X
    Cancer Biol Ther; 2015; 16(7):1110-8. PubMed ID: 25996664
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. Histopathological predictors for local recurrence in patients with T3 and T4 rectal cancers without preoperative chemoradiotherapy.
    Akagi Y; Hisaka T; Mizobe T; Kinugasa T; Ogata Y; Shirouzu K
    J Surg Oncol; 2014 Nov; 110(6):739-44. PubMed ID: 24962179
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. Characterization of BARD1 targeting and dynamics at the centrosome: the role of crm1, BRCA1 and the Q564H mutation.
    Brodie KM; Mok MTS; Henderson BR
    Cell Signal; 2012 Feb; 24(2):451-459. PubMed ID: 21982881
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Nuclear APC.
    Neufeld KL
    Adv Exp Med Biol; 2009; 656():13-29. PubMed ID: 19928349
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. SUMOylation regulates nuclear localization of Krüppel-like factor 5.
    Du JX; Bialkowska AB; McConnell BB; Yang VW
    J Biol Chem; 2008 Nov; 283(46):31991-2002. PubMed ID: 18782761
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. The survivin isoform survivin-3B is cytoprotective and can function as a chromosomal passenger complex protein.
    Knauer SK; Bier C; Schlag P; Fritzmann J; Dietmaier W; Rödel F; Klein-Hitpass L; Kovács AF; Döring C; Hansmann ML; Hofmann WK; Kunkel M; Brochhausen C; Engels K; Lippert BM; Mann W; Stauber RH
    Cell Cycle; 2007 Jun; 6(12):1502-9. PubMed ID: 17582222
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. Nuclear export is essential for the tumor-promoting activity of survivin.
    Knauer SK; Krämer OH; Knösel T; Engels K; Rödel F; Kovács AF; Dietmaier W; Klein-Hitpass L; Habtemichael N; Schweitzer A; Brieger J; Rödel C; Mann W; Petersen I; Heinzel T; Stauber RH
    FASEB J; 2007 Jan; 21(1):207-16. PubMed ID: 17099069
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. LZTS2 is a novel beta-catenin-interacting protein and regulates the nuclear export of beta-catenin.
    Thyssen G; Li TH; Lehmann L; Zhuo M; Sharma M; Sun Z
    Mol Cell Biol; 2006 Dec; 26(23):8857-67. PubMed ID: 17000760
    [TBL] [Abstract] [Full Text] [Related]  


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