Terms: = Gastric cancer AND MAP2K1, MAPKK1, 5604, ENSG00000169032, Q02750, MEK1, MKK1, PRKMK1 AND Treatment
29 results:
1. Myotubularin-related-protein-7 inhibits mutant (G12V) K-RAS by direct interaction.
Weidner P; Saar D; Söhn M; Schroeder T; Yu Y; Zöllner FG; Ponelies N; Zhou X; Zwicky A; Rohrbacher FN; Pattabiraman VR; Tanriver M; Bauer A; Ahmed H; Ametamey SM; Riffel P; Seger R; Bode JW; Wade RC; Ebert MPA; Kragelund BB; Burgermeister E
Cancer Lett; 2024 Apr; 588():216783. PubMed ID: 38462034
[TBL] [Abstract] [Full Text] [Related]
2. Ceramide promotes lytic reactivation of Epstein-Barr virus in gastric carcinoma.
Kim JY; Min YJ; Lee M-H; An YR; Ashktorab H; Smoot DT; Kwon SW; Lee SK
J Virol; 2024 Feb; 98(2):e0177623. PubMed ID: 38197630
[TBL] [Abstract] [Full Text] [Related]
3. High In Vitro and In Vivo Activity of BI-847325, a Dual MEK/Aurora Kinase Inhibitor, in Human Solid and Hematologic cancer Models.
Vuaroqueaux V; Musch A; Peille AL; Kelter G; Weichert L; Metz T; Hendriks HR; Fiebig HH
Cancer Res Commun; 2023 Oct; 3(10):2170-2181. PubMed ID: 37830744
[TBL] [Abstract] [Full Text] [Related]
4. Exploring the Potential Mechanism of Action of Ursolic Acid against gastric cancer and COVID-19 using Network Pharmacology and Bioinformatics Analysis.
Liu Z; Huang H; Yu Y; Jia Y; Li L; Shi X; Wang F
Curr Pharm Des; 2023; 29(16):1274-1292. PubMed ID: 37218202
[TBL] [Abstract] [Full Text] [Related]
5. MicroRNA-34c-5p exhibits anticancer properties in gastric cancer by targeting map2k1 to inhibit cell proliferation, migration, and invasion.
Ma Q; Zhao Y; Li Z; Gao W; Xu Y; Li B; Huang Y; Huo Z
Biomed Res Int; 2022; 2022():7375661. PubMed ID: 36203485
[TBL] [Abstract] [Full Text] [Related]
6. Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis.
Sangwan V; Al-Marzouki L; Pal S; Stavrakos V; Alzahrani M; Antonatos D; Nevo Y; Camilleri-Broët S; Rayes R; Bourdeau F; Giannias B; Bertos N; Bailey S; Rousseau S; Cools-Lartigue J; Spicer JD; Ferri L
Clin Exp Metastasis; 2022 Apr; 39(2):323-333. PubMed ID: 34767138
[TBL] [Abstract] [Full Text] [Related]
7. Hyperactivation of MEK/ERK pathway by Ca
Najar MA; Aravind A; Dagamajalu S; Sidransky D; Ashktorab H; Smoot DT; Gowda H; Prasad TSK; Modi PK; Chatterjee A
Mol Carcinog; 2021 Nov; 60(11):769-783. PubMed ID: 34437731
[TBL] [Abstract] [Full Text] [Related]
8. Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer.
Mezynski MJ; Farrelly AM; Cremona M; Carr A; Morgan C; Workman J; Armstrong P; McAuley J; Madden S; Fay J; Sheehan KM; Kay EW; Holohan C; Elamin Y; Rafee S; Morris PG; Breathnach O; Grogan L; Hennessy BT; Toomey S
J Transl Med; 2021 May; 19(1):184. PubMed ID: 33933113
[TBL] [Abstract] [Full Text] [Related]
9. A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling.
Jiang T; Xia Y; Lv J; Li B; Li Y; Wang S; Xuan Z; Xie L; Qiu S; He Z; Wang L; Xu Z
Mol Cancer; 2021 Apr; 20(1):66. PubMed ID: 33836754
[TBL] [Abstract] [Full Text] [Related]
10. p-MEK expression predicts prognosis of patients with adenocarcinoma of esophagogastric junction (AEG) and plays a role in anti-AEG efficacy of Huaier.
Yuan L; Mo SW; Xu ZY; Lv H; Xu JL; Guo KB; Hu C; Wang XF; Chen GP; Qin JJ; Cheng XD
Pharmacol Res; 2021 Mar; 165():105411. PubMed ID: 33401002
[TBL] [Abstract] [Full Text] [Related]
11. Determining the effects of trastuzumab, cetuximab and afatinib by phosphoprotein, gene expression and phenotypic analysis in gastric cancer cell lines.
Ebert K; Zwingenberger G; Barbaria E; Keller S; Heck C; Arnold R; Hollerieth V; Mattes J; Geffers R; Raimúndez E; Hasenauer J; Luber B
BMC Cancer; 2020 Oct; 20(1):1039. PubMed ID: 33115415
[TBL] [Abstract] [Full Text] [Related]
12. JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis.
Chen JJ; Ren YL; Shu CJ; Zhang Y; Chen MJ; Xu J; Li J; Li AP; Chen DY; He JD; Shu YQ; Zhou JW
J Exp Clin Cancer Res; 2020 Jun; 39(1):118. PubMed ID: 32576271
[TBL] [Abstract] [Full Text] [Related]
13. Upregulation of EphB3 in gastric cancer with acquired resistance to a FGFR inhibitor.
Lee SY; Na YJ; Jeong YA; Kim JL; Oh SC; Lee DH
Int J Biochem Cell Biol; 2018 Sep; 102():128-137. PubMed ID: 30044964
[TBL] [Abstract] [Full Text] [Related]
14. Glucose-derived AGEs promote migration and invasion of colorectal cancer by up-regulating Sp1 expression.
Deng R; Wu H; Ran H; Kong X; Hu L; Wang X; Su Q
Biochim Biophys Acta Gen Subj; 2017 May; 1861(5 Pt A):1065-1074. PubMed ID: 28237576
[TBL] [Abstract] [Full Text] [Related]
15. Sustained ERK activation-mediated proliferation inhibition of farrerol on human gastric carcinoma cell line by G0/G1-phase cell-cycle arrest.
Liu E; Li J; Shi S; Wang X; Liang T; Wu B; Li Q
Eur J Cancer Prev; 2016 Nov; 25(6):490-9. PubMed ID: 26656929
[TBL] [Abstract] [Full Text] [Related]
16. Identification of an "Exceptional Responder" Cell Line to mek1 Inhibition: Clinical Implications for MEK-Targeted Therapy.
Gannon HS; Kaplan N; Tsherniak A; Vazquez F; Weir BA; Hahn WC; Meyerson M
Mol Cancer Res; 2016 Feb; 14(2):207-15. PubMed ID: 26582713
[TBL] [Abstract] [Full Text] [Related]
17. EGFR and HER2 signals play a salvage role in mek1-mutated gastric cancer after MEK inhibition.
Mizukami T; Togashi Y; Sogabe S; Banno E; Terashima M; De Velasco MA; Sakai K; Fujita Y; Tomida S; Nakajima TE; Boku N; Nishio K
Int J Oncol; 2015 Aug; 47(2):499-505. PubMed ID: 26081723
[TBL] [Abstract] [Full Text] [Related]
18. Whole genome gene copy number profiling of gastric cancer identifies PAK1 and KRAS gene amplification as therapy targets.
Qian Z; Zhu G; Tang L; Wang M; Zhang L; Fu J; Huang C; Fan S; Sun Y; Lv J; Dong H; Gao B; Su X; Yu D; Zang J; Zhang X; Ji J; Ji Q
Genes Chromosomes Cancer; 2014 Nov; 53(11):883-94. PubMed ID: 24935174
[TBL] [Abstract] [Full Text] [Related]
19. [Mechanisms of (2-methyl-n-butyl) shikonin induced apoptosis of gastric cancer SGC-7901 cells].
Wang HB; Ma XQ
Yao Xue Xue Bao; 2012 Jun; 47(6):816-21. PubMed ID: 22919733
[TBL] [Abstract] [Full Text] [Related]
20. Oncogenic map2k1 mutations in human epithelial tumors.
Choi YL; Soda M; Ueno T; Hamada T; Haruta H; Yamato A; Fukumura K; Ando M; Kawazu M; Yamashita Y; Mano H
Carcinogenesis; 2012 May; 33(5):956-61. PubMed ID: 22327936
[TBL] [Abstract] [Full Text] [Related]
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