Terms: = Germ cell tumor AND CDK12, KIAA0904, CRKRS, 51755, ENSG00000167258, CRK7, CRKR, Q9NYV4
13 results:
1. MYC up-regulation confers vulnerability to dual inhibition of cdk12 and CDK13 in high-risk Group 3 medulloblastoma.
Pitolli C; Marini A; Guerra M; Pieraccioli M; Marabitti V; Palluzzi F; Giacò L; Tamburrini G; Cecconi F; Nazio F; Sette C; Pagliarini V
J Exp Clin Cancer Res; 2023 Aug; 42(1):214. PubMed ID: 37599362
[TBL] [Abstract] [Full Text] [Related]
2. The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.
Zhao W; Zhang L; Zhang Y; Jiang Z; Lu H; Xie Y; Han W; Zhao W; He J; Shi Z; Yang H; Chen J; Chen S; Li Z; Mao J; Zhou L; Gao X; Li W; Tan G; Zhang B; Wang Z
Cell Death Dis; 2023 Jan; 14(1):11. PubMed ID: 36624090
[TBL] [Abstract] [Full Text] [Related]
3. cdk12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Houles T; Lavoie G; Nourreddine S; Cheung W; Vaillancourt-Jean É; Guérin CM; Bouttier M; Grondin B; Lin S; Saba-El-Leil MK; Angers S; Meloche S; Roux PP
Nat Commun; 2022 Oct; 13(1):6457. PubMed ID: 36309522
[TBL] [Abstract] [Full Text] [Related]
4. A novel germline EGFR variant p.R831H causes predisposition to familial cdk12-mutant prostate cancer with tandem duplicator phenotype.
Qian K; Wang G; Ju L; Liu J; Luo Y; Wang Y; Peng T; Chen F; Zhang Y; Xiao Y; Wang X
Oncogene; 2020 Oct; 39(44):6871-6878. PubMed ID: 32978518
[TBL] [Abstract] [Full Text] [Related]
5. Cyclin-dependent kinase 12 (cdk12) in chordoma: prognostic and therapeutic value.
Thanindratarn P; Dean DC; Feng W; Wei R; Nelson SD; Hornicek FJ; Duan Z
Eur Spine J; 2020 Dec; 29(12):3214-3228. PubMed ID: 32691223
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6. Human Testis Phosphoproteome Reveals Kinases as Potential Targets in Spermatogenesis and Testicular Cancer.
Castillo J; Knol JC; Korver CM; Piersma SR; Pham TV; de Goeij-de Haas RR; van Pelt AMM; Jimenez CR; Jansen BJH
Mol Cell Proteomics; 2019 Mar; 18(Suppl 1):S132-S144. PubMed ID: 30683686
[TBL] [Abstract] [Full Text] [Related]
7. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.
Zhou J; Tien AC; Alberta JA; Ficarro SB; Griveau A; Sun Y; Deshpande JS; Card JD; Morgan-Smith M; Michowski W; Hashizume R; James CD; Ligon KL; Snider WD; Sicinski P; Marto JA; Rowitch DH; Stiles CD
Cell Rep; 2017 Mar; 18(13):3167-3177. PubMed ID: 28355568
[TBL] [Abstract] [Full Text] [Related]
8. Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma.
Gil Del Alcazar CR; Todorova PK; Habib AA; Mukherjee B; Burma S
Mol Cancer Res; 2016 Oct; 14(10):928-940. PubMed ID: 27358111
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9. Targeting histone deacetylases (HDACs) and Wee1 for treating high-risk neuroblastoma.
Hanmod SS; Wang G; Edwards H; Buck SA; Ge Y; Taub JW; Wang Z
Pediatr Blood Cancer; 2015 Jan; 62(1):52-9. PubMed ID: 25308916
[TBL] [Abstract] [Full Text] [Related]
10. CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Delehouzé C; Godl K; Loaëc N; Bruyère C; Desban N; Oumata N; Galons H; Roumeliotis TI; Giannopoulou EG; Grenet J; Twitchell D; Lahti J; Mouchet N; Galibert MD; Garbis SD; Meijer L
Oncogene; 2014 Dec; 33(50):5675-87. PubMed ID: 24317512
[TBL] [Abstract] [Full Text] [Related]
11. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma.
Cheng CK; Gustafson WC; Charron E; Houseman BT; Zunder E; Goga A; Gray NS; Pollok B; Oakes SA; James CD; Shokat KM; Weiss WA; Fan QW
Proc Natl Acad Sci U S A; 2012 Jul; 109(31):12722-7. PubMed ID: 22802621
[TBL] [Abstract] [Full Text] [Related]
12. Role of a DNA damage checkpoint pathway in ionizing radiation-induced glioblastoma cell migration and invasion.
Vanan I; Dong Z; Tosti E; Warshaw G; Symons M; Ruggieri R
Cell Mol Neurobiol; 2012 Oct; 32(7):1199-208. PubMed ID: 22552889
[TBL] [Abstract] [Full Text] [Related]
13. Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation.
Gompel M; Soulié C; Ceballos-Picot I; Meijer L
Neurosignals; 2004; 13(3):134-43. PubMed ID: 15067201
[TBL] [Abstract] [Full Text] [Related]
