Terms: = Germ cell tumor AND CDK12, KIAA0904, CRKRS, 51755, ENSG00000167258, CRK7, CRKR, Q9NYV4 AND Treatment
6 results:
1. MYC up-regulation confers vulnerability to dual inhibition of cdk12 and CDK13 in high-risk Group 3 medulloblastoma.
Pitolli C; Marini A; Guerra M; Pieraccioli M; Marabitti V; Palluzzi F; Giacò L; Tamburrini G; Cecconi F; Nazio F; Sette C; Pagliarini V
J Exp Clin Cancer Res; 2023 Aug; 42(1):214. PubMed ID: 37599362
[TBL] [Abstract] [Full Text] [Related]
2. The CDK inhibitor AT7519 inhibits human glioblastoma cell growth by inducing apoptosis, pyroptosis and cell cycle arrest.
Zhao W; Zhang L; Zhang Y; Jiang Z; Lu H; Xie Y; Han W; Zhao W; He J; Shi Z; Yang H; Chen J; Chen S; Li Z; Mao J; Zhou L; Gao X; Li W; Tan G; Zhang B; Wang Z
Cell Death Dis; 2023 Jan; 14(1):11. PubMed ID: 36624090
[TBL] [Abstract] [Full Text] [Related]
3. cdk12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma.
Houles T; Lavoie G; Nourreddine S; Cheung W; Vaillancourt-Jean É; Guérin CM; Bouttier M; Grondin B; Lin S; Saba-El-Leil MK; Angers S; Meloche S; Roux PP
Nat Commun; 2022 Oct; 13(1):6457. PubMed ID: 36309522
[TBL] [Abstract] [Full Text] [Related]
4. Augmented HR Repair Mediates Acquired Temozolomide Resistance in Glioblastoma.
Gil Del Alcazar CR; Todorova PK; Habib AA; Mukherjee B; Burma S
Mol Cancer Res; 2016 Oct; 14(10):928-940. PubMed ID: 27358111
[TBL] [Abstract] [Full Text] [Related]
5. Targeting histone deacetylases (HDACs) and Wee1 for treating high-risk neuroblastoma.
Hanmod SS; Wang G; Edwards H; Buck SA; Ge Y; Taub JW; Wang Z
Pediatr Blood Cancer; 2015 Jan; 62(1):52-9. PubMed ID: 25308916
[TBL] [Abstract] [Full Text] [Related]
6. CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.
Delehouzé C; Godl K; Loaëc N; Bruyère C; Desban N; Oumata N; Galons H; Roumeliotis TI; Giannopoulou EG; Grenet J; Twitchell D; Lahti J; Mouchet N; Galibert MD; Garbis SD; Meijer L
Oncogene; 2014 Dec; 33(50):5675-87. PubMed ID: 24317512
[TBL] [Abstract] [Full Text] [Related]
