Terms: = Germ cell tumor AND SMO, Q99835, 6608, ENSG00000128602, SMOH, Gx AND Treatment
64 results:
1. Arsenic Trioxide inhibits Activation of Hedgehog Pathway in Human Neuroblastoma cell Line SK-N-BE(2) Independent of Itraconazole.
Liu X; Wang Z; Xiong X; Li C; Wu Y; Su M; Yang S; Zeng M; Weng W; Huang K; Zhou D; Fang J; Xu L; Li P; Zhu Y; Qiu K; Ma Y; Lei J; Li Y
Anticancer Agents Med Chem; 2023; 23(20):2217-2224. PubMed ID: 37888819
[TBL] [Abstract] [Full Text] [Related]
2. Intraventricular SHH inhibition proves efficient in SHH medulloblastoma mouse model and prevents systemic side effects.
Kresbach C; Holst L; Schoof M; Leven T; Göbel C; Neyazi S; Tischendorf J; Loose C; Wrzeszcz A; Yorgan T; Rutkowski S; Schüller U
Neuro Oncol; 2024 Apr; 26(4):609-622. PubMed ID: 37767814
[TBL] [Abstract] [Full Text] [Related]
3. smo-CRISPR-mediated apoptosis in CD133-targeted cancer stem cells and tumor growth inhibition.
Pandey S; Lee M; Lim J; Park S; Choung YH; Kim JE; Garg P; Chung JH
J Control Release; 2023 May; 357():94-108. PubMed ID: 36931470
[TBL] [Abstract] [Full Text] [Related]
4. circRNA-smo upregulates CEP85 to promote proliferation and migration of glioblastoma via sponging miR-326.
Wu B; Xia L; Zhang S; Jin K; Li L; Sun C; Xia T; Chen G
Histol Histopathol; 2023 Nov; 38(11):1307-1319. PubMed ID: 36718820
[TBL] [Abstract] [Full Text] [Related]
5. ABTC-0904: targeting glioma stem cells in GBM: a phase 0/II study of hedgehog pathway inhibitor GDC-0449.
Sloan AE; Nock CJ; Ye X; Buerki R; Chang S; Lesser G; Norden A; Cloughesy T; Olson J; Kerstetter-Fogle A; Rich J; Fisher J; Desideri S; Takebe N; Timmer W; Grossman S; Prados M
J Neurooncol; 2023 Jan; 161(1):33-43. PubMed ID: 36581779
[TBL] [Abstract] [Full Text] [Related]
6. Noncanonical activation of GLI signaling in SOX2
Swiderska-Syn M; Mir-Pedrol J; Oles A; Schleuger O; Salvador AD; Greiner SM; Seward C; Yang F; Babcock BR; Shen C; Wynn DT; Sanchez-Mejias A; Gershon TR; Martin V; McCrea HJ; Lindsey KG; Krieg C; Rodriguez-Blanco J
Sci Adv; 2022 Jul; 8(29):eabj9138. PubMed ID: 35857834
[TBL] [Abstract] [Full Text] [Related]
7. Curcumin analogue BDDD-721 exhibits more potent anticancer effects than curcumin on medulloblastoma by targeting Shh/Gli1 signaling pathway.
Gong W; Zhao W; Liu G; Shi L; Zhao X
Aging (Albany NY); 2022 Jul; 14(13):5464-5477. PubMed ID: 35802536
[TBL] [Abstract] [Full Text] [Related]
8. Activation of Hedgehog signaling by the oncogenic RELA fusion reveals a primary cilia-dependent vulnerability in supratentorial ependymoma.
de Almeida Magalhães T; Alencastro Veiga Cruzeiro G; Ribeiro de Sousa G; Englinger B; Fernando Peinado Nagano L; Ancliffe M; Rodrigues da Silva K; Jiang L; Gojo J; Cherry Liu Y; Carline B; Kuchibhotla M; Pinto Saggioro F; Kazue Nagahashi Marie S; Mieko Oba-Shinjo S; Andres Yunes J; Gomes de Paula Queiroz R; Alberto Scrideli C; Endersby R; Filbin MG; Silva Borges K; Salic A; Gonzaga Tone L; Valera ET
Neuro Oncol; 2023 Jan; 25(1):185-198. PubMed ID: 35640920
[TBL] [Abstract] [Full Text] [Related]
9. Targeting AKT and CK2 represents a novel therapeutic strategy for smo constitutive activation-driven medulloblastoma.
Yao YL; Wang YX; Yang FC; Wang C; Mao M; Gai QJ; He J; Qin Y; Yao XX; Lan X; Zhu J; Lu HM; Zeng H; Yao XH; Bian XW; Wang Y
CNS Neurosci Ther; 2022 Jul; 28(7):1033-1044. PubMed ID: 35419951
[TBL] [Abstract] [Full Text] [Related]
10. [Medulloblastoma].
Kanemura Y
No Shinkei Geka; 2022 Jan; 50(1):73-90. PubMed ID: 35169088
[TBL] [Abstract] [Full Text] [Related]
11. GLI-1 polymorphisms of Hedgehog pathway as novel risk and prognostic biomarkers in melanoma patients.
Dunjic M; Lukic N; Djordjevic B; Uzelac B; Ostojic N; Supic G
Melanoma Res; 2022 Feb; 32(1):11-17. PubMed ID: 34939981
[TBL] [Abstract] [Full Text] [Related]
12. STAT3 is required for smo-dependent signaling and mediates smo-targeted treatment resistance and tumorigenesis in Shh medulloblastoma.
Yuan L; Zhang H; Liu J; Malhotra A; Dey A; Yu B; Jella KK; McSwain LF; Schniederjan MJ; MacDonald TJ
Mol Oncol; 2022 Feb; 16(4):1009-1025. PubMed ID: 34482626
[TBL] [Abstract] [Full Text] [Related]
13. G-protein-coupled receptors as therapeutic targets for glioblastoma.
Byrne KF; Pal A; Curtin JF; Stephens JC; Kinsella GK
Drug Discov Today; 2021 Dec; 26(12):2858-2870. PubMed ID: 34271165
[TBL] [Abstract] [Full Text] [Related]
14. Identification of Clinical Relevant Molecular Subtypes of Pheochromocytoma.
Saddozai UAK; Wang F; Akbar MU; Zhang L; An Y; Zhu W; Xie L; Li Y; Ji X; Guo X
Front Endocrinol (Lausanne); 2021; 12():605797. PubMed ID: 34234737
[TBL] [Abstract] [Full Text] [Related]
15. Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma.
Wei SF; He DH; Zhang SB; Lu Y; Ye X; Fan XZ; Wang H; Wang Q; Liu YQ
Biochem Pharmacol; 2021 Aug; 190():114593. PubMed ID: 33964282
[TBL] [Abstract] [Full Text] [Related]
16. Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.
Pietrobono S; Gaudio E; Gagliardi S; Zitani M; Carrassa L; Migliorini F; Petricci E; Manetti F; Makukhin N; Bond AG; Paradise BD; Ciulli A; Fernandez-Zapico ME; Bertoni F; Stecca B
Oncogene; 2021 Jun; 40(22):3799-3814. PubMed ID: 33958721
[TBL] [Abstract] [Full Text] [Related]
17. Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.
Gao LJ; Zhang MZ; Li XY; Huang WK; Xu SF; Ye YP
Bioorg Med Chem; 2021 Jun; 39():116166. PubMed ID: 33910157
[TBL] [Abstract] [Full Text] [Related]
18. Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator.
Korshunov A; Okonechnikov K; Stichel D; Ryzhova M; Schrimpf D; Sahm F; Sievers P; Absalyamova O; Zheludkova O; Golanov A; Jones DTW; Pfister SM; von Deimling A; Kool M
Neuro Oncol; 2021 Sep; 23(9):1576-1585. PubMed ID: 33589929
[TBL] [Abstract] [Full Text] [Related]
19. A novel protein encoded by circular smo RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.
Wu X; Xiao S; Zhang M; Yang L; Zhong J; Li B; Li F; Xia X; Li X; Zhou H; Liu D; Huang N; Yang X; Xiao F; Zhang N
Genome Biol; 2021 Jan; 22(1):33. PubMed ID: 33446260
[TBL] [Abstract] [Full Text] [Related]
20. Clinical and mutational profiles of adult medulloblastoma groups.
Wong GC; Li KK; Wang WW; Liu AP; Huang QJ; Chan AK; Poon MF; Chung NY; Wong QH; Chen H; Chan DTM; Liu XZ; Mao Y; Zhang ZY; Shi ZF; Ng HK
Acta Neuropathol Commun; 2020 Nov; 8(1):191. PubMed ID: 33172502
[TBL] [Abstract] [Full Text] [Related]
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