Terms: = Head and neck cancer AND MAP2K1, MAPKK1, 5604, ENSG00000169032, Q02750, MEK1, MKK1, PRKMK1
141 results:
1. The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies.
Hicks HM; Nassar VL; Lund J; Rose MM; Schweppe RE
Cancer Biol Ther; 2024 Dec; 25(1):2332000. PubMed ID: 38521968
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2. AKT-independent signaling in PIK3CA-mutant thyroid cancer mediates resistance to dual SRC and mek1/2 inhibition.
Rose MM; Nassar KW; Sharma V; Schweppe RE
Med Oncol; 2023 Sep; 40(10):299. PubMed ID: 37713162
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3. Treatment experience with encorafenib plus binimetinib for BRAF V600-mutant metastatic melanoma: management insights for clinical practice.
Augustyn K; Joseph J; Patel AB; Razmandi A; Ali AN; Tawbi HA
Melanoma Res; 2023 Oct; 33(5):406-416. PubMed ID: 37534686
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4. Activation of the EGFR/PI3K/AKT pathway limits the efficacy of trametinib treatment in head and neck cancer.
Novoplansky O; Shnerb AB; Marripati D; Jagadeeshan S; Abu Shareb R; Conde-López C; Zorea J; Prasad M; Ben Lulu T; Yegodayev KM; Benafsha C; Li Y; Kong D; Kuo F; Morris LGT; Kurth I; Hess J; Elkabets M
Mol Oncol; 2023 Dec; 17(12):2618-2636. PubMed ID: 37501404
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5. Visfatin upregulates VEGF-C expression and lymphangiogenesis in esophageal cancer by activating mek1/2-ERK and NF-κB signaling.
Huang CL; Achudhan D; Liu PI; Lin YY; Liu SC; Guo JH; Liu CL; Wu CY; Wang SW; Tang CH
Aging (Albany NY); 2023 Jun; 15(11):4774-4793. PubMed ID: 37286356
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6. Fibronectin Contributes to a BRAF Inhibitor-driven Invasive Phenotype in Thyroid cancer through EGR1, Which Can Be Blocked by Inhibition of ERK1/2.
Hicks HM; Pozdeyev N; Sams SB; Pugazhenthi U; Bales ES; Hofmann MC; McKenna LR; Schweppe RE
Mol Cancer Res; 2023 Sep; 21(9):867-880. PubMed ID: 37219859
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7. MiR-942-5p inhibits tumor migration and invasion through targeting CST1 in esophageal squamous cell carcinoma.
Zhang L; Yu S; Yin X; Tu M; Cai L; Zhang Y; Yu L; Zhang S; Pan X; Huang Y
PLoS One; 2023; 18(2):e0277006. PubMed ID: 36848349
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8. EBV LMP1-C terminal binding affibody molecule downregulates MEK/ERK/p90RSK pathway and inhibits the proliferation of nasopharyngeal carcinoma cells in mouse tumor xenograft models.
Guo Y; Kamara S; Zhang J; Wen H; Zheng M; Liu Y; Zhou L; Chen J; Zhu S; Zhang L
Front Cell Infect Microbiol; 2022; 12():1078504. PubMed ID: 36683690
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9. Daurisoline suppresses esophageal squamous cell carcinoma growth in vitro and in vivo by targeting mek1/2 kinase.
Wang D; Zhang W; Zhang X; Li M; Wu Q; Li X; Zhao L; Yuan Q; Yu Y; Lu J; Zhao J; Dong Z; Liu K; Jiang Y
Mol Carcinog; 2023 Apr; 62(4):517-531. PubMed ID: 36645220
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10. Involvement of AMPKα and MAPK-ERK/-JNK Signals in Docetaxel-Induced Human Tongue Squamous Cell Carcinoma Cell Apoptosis.
Su CC; Lin JW; Chang KY; Wu CT; Liu SH; Chang KC; Liu JM; Lee KI; Fang KM; Chen YW
Int J Mol Sci; 2022 Nov; 23(22):. PubMed ID: 36430348
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11. TOMM34 promotes cell proliferation, migration, and invasion of OSCC and modulates mitochondrial function.
Huang Y; Chen Z; Chen X; Chen X; Xu M
J Oral Pathol Med; 2023 Jan; 52(1):47-55. PubMed ID: 36367442
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12. Reiterative modeling of combined transcriptomic and proteomic features refines and improves the prediction of early recurrence in squamous cell carcinoma of head and neck.
Salehi A; Wang L; Coates PJ; Norberg Spaak L; Gu X; Sgaramella N; Nylander K
Comput Biol Med; 2022 Oct; 149():105991. PubMed ID: 36007290
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13. Identification of a BRAF/PA28γ/mek1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis.
Xie C; Li Z; Hua Y; Sun S; Zhong L; Chen Q; Feng H; Ji N; Li T; Zhou X; Zeng X; Tang Z; Sun C; Li J; Chen Q
Cell Death Dis; 2022 Aug; 13(8):701. PubMed ID: 35961969
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14. Inhibition of angiogenesis and tumor progression of MK-0429, an integrin αvβ
Nakagawa T; Ohta K; Naruse T; Sakuma M; Fukada S; Yamakado N; Akagi M; Sasaki K; Niwata C; Ono S; Aikawa T
J Cancer Res Clin Oncol; 2022 Dec; 148(12):3281-3292. PubMed ID: 35713706
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15. Novel Therapeutics for Advanced Differentiated Thyroid cancer.
Lieberman L; Worden F
Endocrinol Metab Clin North Am; 2022 Jun; 51(2):367-378. PubMed ID: 35662446
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16. MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma
Wang M; Huang C; Gao W; Zhu Y; Zhang F; Li Z; Tian Z
Aging (Albany NY); 2022 Apr; 14(8):3540-3553. PubMed ID: 35468097
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17. Dysregulation of CXCL14 promotes malignant phenotypes of esophageal squamous carcinoma cells via regulating SRC and EGFR signaling.
Guo J; Chang C; Yang LY; Cai HQ; Chen DX; Zhang Y; Cai Y; Wang JJ; Wei WQ; Hao JJ; Wang MR
Biochem Biophys Res Commun; 2022 Jun; 609():75-83. PubMed ID: 35421632
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18. mek1/2 inhibition transiently alters the tumor immune microenvironment to enhance immunotherapy efficacy against head and neck cancer.
Prasad M; Zorea J; Jagadeeshan S; Shnerb AB; Mathukkada S; Bouaoud J; Michon L; Novoplansky O; Badarni M; Cohen L; Yegodayev KM; Tzadok S; Rotblat B; Brezina L; Mock A; Karabajakian A; Fayette J; Cohen I; Cooks T; Allon I; Dimitstein O; Joshua B; Kong D; Voronov E; Scaltriti M; Carmi Y; Conde-Lopez C; Hess J; Kurth I; Morris LGT; Saintigny P; Elkabets M
J Immunother Cancer; 2022 Mar; 10(3):. PubMed ID: 35292516
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19. Integrative pan-cancer analysis of mek1 aberrations and the potential clinical implications.
Zhou Z; Peng B; Li J; Gao K; Cai Y; Xu Z; Yan Y
Sci Rep; 2021 Sep; 11(1):18366. PubMed ID: 34526571
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20. Hyperactivation of MEK/ERK pathway by Ca
Najar MA; Aravind A; Dagamajalu S; Sidransky D; Ashktorab H; Smoot DT; Gowda H; Prasad TSK; Modi PK; Chatterjee A
Mol Carcinog; 2021 Nov; 60(11):769-783. PubMed ID: 34437731
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