Terms: = Leukemia AND MLLT1, ENL, 4298, ENSG00000130382, Q03111, YEATS1, LTG19 AND Treatment
47 results:
1. Targeting the Epigenetic Reader enl Inhibits Super-Enhancer-Driven Oncogenic Transcription and Synergizes with BET Inhibition to Suppress Tumor Progression.
Chen Y; Ying Y; Ma W; Ma H; Shi L; Gao X; Jia M; Li M; Song X; Kong W; Chen W; Zheng X; Muluh TA; Wang X; Wang M; Shu XS
Cancer Res; 2024 Apr; 84(8):1237-1251. PubMed ID: 38241700
[TBL] [Abstract] [Full Text] [Related]
2. Droplet Digital PCR for Oncogenic KMT2A Fusion Detection.
Young AL; Davis HC; Challen GA
J Mol Diagn; 2023 Dec; 25(12):898-906. PubMed ID: 37813299
[TBL] [Abstract] [Full Text] [Related]
3. Small-Molecule Inhibition of the Acyl-Lysine Reader enl as a Strategy against Acute Myeloid leukemia.
Liu Y; Li Q; Alikarami F; Barrett DR; Mahdavi L; Li H; Tang S; Khan TA; Michino M; Hill C; Song L; Yang L; Li Y; Pokharel SP; Stamford AW; Liverton N; Renzetti LM; Taylor S; Watt GF; Ladduwahetty T; Kargman S; Meinke PT; Foley MA; Shi J; Li H; Carroll M; Chen CW; Gardini A; Maillard I; Huggins DJ; Bernt KM; Wan L
Cancer Discov; 2022 Nov; 12(11):2684-2709. PubMed ID: 36053276
[TBL] [Abstract] [Full Text] [Related]
4. Poor treatment responses were related to poor outcomes in pediatric B cell acute lymphoblastic leukemia with KMT2A rearrangements.
Wen J; Zhou M; Shen Y; Long Y; Guo Y; Song L; Xiao J
BMC Cancer; 2022 Aug; 22(1):859. PubMed ID: 35933338
[TBL] [Abstract] [Full Text] [Related]
5. Design, Synthesis, and Biological Evaluations of DOT1L Peptide Mimetics Targeting the Protein-Protein Interactions between DOT1L and MLL-AF9/MLL-enl.
Yuan Y; Du L; Tan R; Yu Y; Jiang J; Yao A; Luo J; Tang R; Xiao Y; Sun H
J Med Chem; 2022 Jun; 65(11):7770-7785. PubMed ID: 35612819
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6. Fragment-Based Discovery of AF9 YEATS Domain Inhibitors.
Liu Y; Jin R; Lu H; Bian K; Wang R; Wang L; Gao R; Zhang J; Wu J; Yao X; Liu X; Liu D; Wang X; Zhang Z; Ruan K
Int J Mol Sci; 2022 Mar; 23(7):. PubMed ID: 35409252
[TBL] [Abstract] [Full Text] [Related]
7. KAT6A and enl Form an Epigenetic Transcriptional Control Module to Drive Critical Leukemogenic Gene-Expression Programs.
Yan F; Li J; Milosevic J; Petroni R; Liu S; Shi Z; Yuan S; Reynaga JM; Qi Y; Rico J; Yu S; Liu Y; Rokudai S; Palmisiano N; Meyer SE; Sung PJ; Wan L; Lan F; Garcia BA; Stanger BZ; Sykes DB; Blanco MA
Cancer Discov; 2022 Mar; 12(3):792-811. PubMed ID: 34853079
[TBL] [Abstract] [Full Text] [Related]
8. Chimeric antigen receptor T cells targeting CD7 in a child with high-risk T-cell acute lymphoblastic leukemia.
Xie L; Ma L; Liu S; Chang L; Wen F
Int Immunopharmacol; 2021 Jul; 96():107731. PubMed ID: 33965880
[TBL] [Abstract] [Full Text] [Related]
9. Structure, function and inhibition of critical protein-protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins.
Li X; Song Y
J Hematol Oncol; 2021 Apr; 14(1):56. PubMed ID: 33823889
[TBL] [Abstract] [Full Text] [Related]
10. Phase 1 study of belinostat (PXD-101) and bortezomib (Velcade, PS-341) in patients with relapsed or refractory acute leukemia and myelodysplastic syndrome.
Holkova B; Shafer D; Yazbeck V; Dave S; Bose P; Tombes MB; Shrader E; Wan W; Bandyopadhyay D; Weir C; Collins EB; Garnett A; Kmieciak M; Roberts JD; Garcia-Manero G; Grant S
Leuk Lymphoma; 2021 May; 62(5):1187-1194. PubMed ID: 33356689
[TBL] [Abstract] [Full Text] [Related]
11. The anti-cancer effect of flaxseed lignan derivatives on different acute myeloid leukemia cancer cells.
Tannous S; Haykal T; Dhaini J; Hodroj MH; Rizk S
Biomed Pharmacother; 2020 Dec; 132():110884. PubMed ID: 33080470
[TBL] [Abstract] [Full Text] [Related]
12. Fusion partner-specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML.
Matsuo H; Yoshida K; Nakatani K; Harata Y; Higashitani M; Ito Y; Kamikubo Y; Shiozawa Y; Shiraishi Y; Chiba K; Tanaka H; Okada A; Nannya Y; Takeda J; Ueno H; Kiyokawa N; Tomizawa D; Taga T; Tawa A; Miyano S; Meggendorfer M; Haferlach C; Ogawa S; Adachi S
Blood Adv; 2020 Oct; 4(19):4623-4631. PubMed ID: 32991719
[TBL] [Abstract] [Full Text] [Related]
13. Exploitable metabolic dependencies in MLL-enl-induced leukemia.
Garcia-Cuellar MP; Lawlor J; Böttcher M; Mougiakakos D; Metzler M; Slany RK
Blood Adv; 2020 Aug; 4(15):3626-3638. PubMed ID: 32766858
[TBL] [Abstract] [Full Text] [Related]
14. [Expression Level and Target Gene Prediction of miR-181b in Patients with Chronic Lymphocytic leukemia].
Liang XP; Sun J; Shao MM; Wu YH; Li N; Han WX; Wang HD
Zhongguo Shi Yan Xue Ye Xue Za Zhi; 2020 Jun; 28(3):842-848. PubMed ID: 32552945
[TBL] [Abstract] [Full Text] [Related]
15. MLL-Rearranged Acute Lymphoblastic leukemia.
El Chaer F; Keng M; Ballen KK
Curr Hematol Malig Rep; 2020 Apr; 15(2):83-89. PubMed ID: 32350732
[TBL] [Abstract] [Full Text] [Related]
16. Cell-Based Ligand Discovery for the enl YEATS Domain.
Asiaban JN; Milosevich N; Chen E; Bishop TR; Wang J; Zhang Y; Ackerman CJ; Hampton EN; Young TS; Hull MV; Cravatt BF; Erb MA
ACS Chem Biol; 2020 Apr; 15(4):895-903. PubMed ID: 32176478
[TBL] [Abstract] [Full Text] [Related]
17. Rationale for targeting BCL6 in
Hurtz C; Chan LN; Geng H; Ballabio E; Xiao G; Deb G; Khoury H; Chen CW; Armstrong SA; Chen J; Ernst P; Melnick A; Milne T; Müschen M
Genes Dev; 2019 Sep; 33(17-18):1265-1279. PubMed ID: 31395741
[TBL] [Abstract] [Full Text] [Related]
18. enl: structure, function, and roles in hematopoiesis and acute myeloid leukemia.
Zhou J; Ng Y; Chng WJ
Cell Mol Life Sci; 2018 Nov; 75(21):3931-3941. PubMed ID: 30066088
[TBL] [Abstract] [Full Text] [Related]
19. Preclinical Efficacy and Safety of CD19CAR Cytokine-Induced Killer Cells Transfected with Sleeping Beauty Transposon for the treatment of Acute Lymphoblastic leukemia.
Magnani CF; Mezzanotte C; Cappuzzello C; Bardini M; Tettamanti S; Fazio G; Cooper LJN; Dastoli G; Cazzaniga G; Biondi A; Biagi E
Hum Gene Ther; 2018 May; 29(5):602-613. PubMed ID: 29641322
[TBL] [Abstract] [Full Text] [Related]
20. CRISPR-Cas9-induced t(11;19)/MLL-enl translocations initiate leukemia in human hematopoietic progenitor cells
Reimer J; Knöß S; Labuhn M; Charpentier EM; Göhring G; Schlegelberger B; Klusmann JH; Heckl D
Haematologica; 2017 Sep; 102(9):1558-1566. PubMed ID: 28572162
[TBL] [Abstract] [Full Text] [Related]
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