Terms: = Liver cancer AND CDK12, KIAA0904, CRKRS, 51755, ENSG00000167258, CRK7, CRKR, Q9NYV4
8 results:
1. cdk12 orchestrates super-enhancer-associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer.
Dai W; Wu J; Peng X; Hou W; Huang H; Cheng Q; Liu Z; Luyten W; Schoofs L; Zhou J; Liu S
Clin Transl Med; 2022 Oct; 12(10):e1087. PubMed ID: 36254394
[TBL] [Abstract] [Full Text] [Related]
2. Hepatoid prostatic carcinoma with adrenal metastasis and novel genetic alterations.
Ayala Soriano C; Benitez Barzaga M; Chhina A; Jain M; Nava VE
Diagn Cytopathol; 2022 Nov; 50(11):E310-E314. PubMed ID: 35765767
[TBL] [Abstract] [Full Text] [Related]
3. Contrasting genomic profiles from metastatic sites, primary tumors, and liquid biopsies of advanced prostate cancer.
Necchi A; Cucchiara V; Grivas P; Bratslavsky G; Jacob J; Spiess PE; Sokol ES; Killian JK; Lin D; Ramkissoon S; Huang RSP; Madison RW; Venstrom JM; Schrock AB; Danziger N; Decker B; Gjoerup O; Graf RP; Oxnard GR; Tukachinsky H; Ross JS
Cancer; 2021 Dec; 127(24):4557-4564. PubMed ID: 34379803
[TBL] [Abstract] [Full Text] [Related]
4. Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual cdk12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Jiang B; Jiang J; Kaltheuner IH; Iniguez AB; Anand K; Ferguson FM; Ficarro SB; Seong BKA; Greifenberg AK; Dust S; Kwiatkowski NP; Marto JA; Stegmaier K; Zhang T; Geyer M; Gray NS
Eur J Med Chem; 2021 Oct; 221():113481. PubMed ID: 33945934
[TBL] [Abstract] [Full Text] [Related]
5. Early-onset metastatic and clinically advanced prostate cancer is a distinct clinical and molecular entity characterized by increased TMPRSS2-ERG fusions.
Chalmers ZR; Burns MC; Ebot EM; Frampton GM; Ross JS; Hussain MHA; Abdulkadir SA
Prostate Cancer Prostatic Dis; 2021 Jun; 24(2):558-566. PubMed ID: 33420417
[TBL] [Abstract] [Full Text] [Related]
6. Liquiritin inhibits proliferation and induces apoptosis in HepG2 hepatocellular carcinoma cells via the ROS-mediated MAPK/AKT/NF-κB signaling pathway.
Wang JR; Li TZ; Wang C; Li SM; Luo YH; Piao XJ; Feng YC; Zhang Y; Xu WT; Zhang Y; Zhang T; Wang SN; Xue H; Wang HX; Cao LK; Jin CH
Naunyn Schmiedebergs Arch Pharmacol; 2020 Oct; 393(10):1987-1999. PubMed ID: 31956937
[TBL] [Abstract] [Full Text] [Related]
7. The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.
van Dessel LF; van Riet J; Smits M; Zhu Y; Hamberg P; van der Heijden MS; Bergman AM; van Oort IM; de Wit R; Voest EE; Steeghs N; Yamaguchi TN; Livingstone J; Boutros PC; Martens JWM; Sleijfer S; Cuppen E; Zwart W; van de Werken HJG; Mehra N; Lolkema MP
Nat Commun; 2019 Nov; 10(1):5251. PubMed ID: 31748536
[TBL] [Abstract] [Full Text] [Related]
8. cdk12 inhibition mediates DNA damage and is synergistic with sorafenib treatment in hepatocellular carcinoma.
Wang C; Wang H; Lieftink C; du Chatinier A; Gao D; Jin G; Jin H; Beijersbergen RL; Qin W; Bernards R
Gut; 2020 Apr; 69(4):727-736. PubMed ID: 31519701
[TBL] [Abstract] [Full Text] [Related]
