Terms: = Liver cancer AND MAP2K4, MEK4, 6416, P45985, ENSG00000065559, SERK1, JNKK1, MKK4, PRKMK4, MAPKK4, JNKK, SEK1
31 results:
1. Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications.
Park JK; Jeong HO; Kim H; Choi JH; Lee EM; Kim S; Jang J; Choi DW; Lee SH; Kim KM; Jang KT; Lee KH; Lee KT; Lee MW; Lee JK; Lee S
Mol Cancer; 2024 May; 23(1):87. PubMed ID: 38702773
[TBL] [Abstract] [Full Text] [Related]
2. First-in-class mkk4 inhibitors enhance liver regeneration and prevent liver failure.
Zwirner S; Abu Rmilah AA; Klotz S; Pfaffenroth B; Kloevekorn P; Moschopoulou AA; Schuette S; Haag M; Selig R; Li K; Zhou W; Nelson E; Poso A; Chen H; Amiot B; Jia Y; Minshew A; Michalak G; Cui W; Rist E; Longerich T; Jung B; Felgendreff P; Trompak O; Premsrirut PK; Gries K; Muerdter TE; Heinkele G; Wuestefeld T; Shapiro D; Weissbach M; Koenigsrainer A; Sipos B; Ab E; Zacarias MO; Theisgen S; Gruenheit N; Biskup S; Schwab M; Albrecht W; Laufer S; Nyberg S; Zender L
Cell; 2024 Mar; 187(7):1666-1684.e26. PubMed ID: 38490194
[TBL] [Abstract] [Full Text] [Related]
3. Yttrium-90 Transarterial Radioembolization of Primary Lung cancer Metastases to the liver.
Alexander ES; Petre EN; Zhao K; Sotirchos V; Namakydoust A; Moussa A; Yuan G; Sofocleous CT; Solomon SB; Ziv E
J Vasc Interv Radiol; 2024 Feb; 35(2):214-225.e2. PubMed ID: 37923172
[TBL] [Abstract] [Full Text] [Related]
4. Components of the JNK-MAPK pathway play distinct roles in hepatocellular carcinoma.
Yu J; Li X; Cao J; Zhu T; Liang S; Du L; Cao M; Wang H; Zhang Y; Zhou Y; Shen B; Feng J; Zhang J; Wang J; Jin J
J Cancer Res Clin Oncol; 2023 Dec; 149(19):17495-17509. PubMed ID: 37902853
[TBL] [Abstract] [Full Text] [Related]
5. Network Pharmacology-Based Identification of Key Pharmacological Mechanism of Shen-qi-di-huang Decoction Acting on Uremia.
Zhang X; Chen XF; Chen WJ; Ding H; Zhang BX
Altern Ther Health Med; 2024 Jan; 30(1):44-50. PubMed ID: 37773677
[TBL] [Abstract] [Full Text] [Related]
6. mkk4 Inhibitors-Recent Development Status and Therapeutic Potential.
Katzengruber L; Sander P; Laufer S
Int J Mol Sci; 2023 Apr; 24(8):. PubMed ID: 37108658
[TBL] [Abstract] [Full Text] [Related]
7. Selinexor demonstrates anti-tumor efficacy in paired patient-derived xenograft models and hydrogel-embedded histoculture drug sensitivity test of penile cancer.
He Y; Mei J; Hao H; Liu F; Yi Y; Hu C; Zou F; Lu X
J Cancer Res Clin Oncol; 2023 Aug; 149(10):6931-6941. PubMed ID: 36840755
[TBL] [Abstract] [Full Text] [Related]
8. Design and synthesis of 1H-pyrazolo[3,4-b]pyridines targeting mitogen-activated protein kinase kinase 4 (mkk4) - A promising target for liver regeneration.
Pfaffenrot B; Klövekorn P; Juchum M; Selig R; Albrecht W; Zender L; Laufer SA
Eur J Med Chem; 2021 Jun; 218():113371. PubMed ID: 33794385
[TBL] [Abstract] [Full Text] [Related]
9. From off-to on-target: New BRAF-inhibitor-template-derived compounds selectively targeting mitogen activated protein kinase kinase 4 (mkk4).
Klövekorn P; Pfaffenrot B; Juchum M; Selig R; Albrecht W; Zender L; Laufer SA
Eur J Med Chem; 2021 Jan; 210():112963. PubMed ID: 33199152
[TBL] [Abstract] [Full Text] [Related]
10. An oral 2-hydroxypropyl-β-cyclodextrin-loaded spirooxindole-pyrrolizidine derivative restores p53 activity via targeting MDM2 and JNK1/2 in hepatocellular carcinoma.
Gao X; Wei M; Shan W; Liu Q; Gao J; Liu Y; Zhu S; Yao H
Pharmacol Res; 2019 Oct; 148():104400. PubMed ID: 31425749
[TBL] [Abstract] [Full Text] [Related]
11. Overexpressed microRNA-136 works as a cancer suppressor in gallbladder cancer through suppression of JNK signaling pathway via inhibition of map2k4.
Niu J; Li Z; Li F
Am J Physiol Gastrointest Liver Physiol; 2019 Nov; 317(5):G670-G681. PubMed ID: 31369289
[TBL] [Abstract] [Full Text] [Related]
12. Synergistic antimetastatic effect of cotreatment with licochalcone A and sorafenib on human hepatocellular carcinoma cells through the inactivation of mkk4/JNK and uPA expression.
Wu MH; Chiu YF; Wu WJ; Wu PL; Lin CY; Lin CL; Hsieh YH; Liu CJ
Environ Toxicol; 2018 Dec; 33(12):1237-1244. PubMed ID: 30187994
[TBL] [Abstract] [Full Text] [Related]
13. β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways.
Huang CF; Teng YH; Lu FJ; Hsu WH; Lin CL; Hung CC; Tung JN; Hsieh YH; Liu CJ
Environ Toxicol; 2017 Nov; 32(11):2360-2370. PubMed ID: 28722351
[TBL] [Abstract] [Full Text] [Related]
14. Downregulation of phosphorylated mkk4 is associated with a poor prognosis in colorectal cancer patients.
Wang PN; Huang J; Duan YH; Zhou JM; Huang PZ; Fan XJ; Huang Y; Wang L; Liu HL; Wang JP; Huang MJ
Oncotarget; 2017 May; 8(21):34352-34361. PubMed ID: 28423721
[TBL] [Abstract] [Full Text] [Related]
15. Toll-like receptor 4 signaling promotes invasion of hepatocellular carcinoma cells through mkk4/JNK pathway.
Dong YQ; Lu CW; Zhang L; Yang J; Hameed W; Chen W
Mol Immunol; 2015 Dec; 68(2 Pt C):671-83. PubMed ID: 26589455
[TBL] [Abstract] [Full Text] [Related]
16. HMGB1 promotes HCC progression partly by downregulating p21 via ERK/c-Myc pathway and upregulating MMP-2.
Chen Y; Lin C; Liu Y; Jiang Y
Tumour Biol; 2016 Apr; 37(4):4399-408. PubMed ID: 26499944
[TBL] [Abstract] [Full Text] [Related]
17. Comprehensive serial molecular profiling of an "N of 1" exceptional non-responder with metastatic prostate cancer progressing to small cell carcinoma on treatment.
Kadakia KC; Tomlins SA; Sanghvi SK; Cani AK; Omata K; Hovelson DH; Liu CJ; Cooney KA
J Hematol Oncol; 2015 Oct; 8():109. PubMed ID: 26444865
[TBL] [Abstract] [Full Text] [Related]
18. Licochalcone A suppresses migration and invasion of human hepatocellular carcinoma cells through downregulation of mkk4/JNK via NF-κB mediated urokinase plasminogen activator expression.
Tsai JP; Hsiao PC; Yang SF; Hsieh SC; Bau DT; Ling CL; Pai CL; Hsieh YH
PLoS One; 2014; 9(1):e86537. PubMed ID: 24466137
[TBL] [Abstract] [Full Text] [Related]
19. [Expression and clinicopathological significance of serine-257/threonine-261 phosphorylated mkk4 in colorectal carcinoma].
Huang MJ; Wang PN; Huang J; Zhang XW; Wang L; Liu HL; Wang JP
Zhonghua Yi Xue Za Zhi; 2013 Mar; 93(10):746-50. PubMed ID: 23755811
[TBL] [Abstract] [Full Text] [Related]
20. Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells.
Ji L; Shen K; Jiang P; Morahan G; Wang Z
Mol Carcinog; 2011 Aug; 50(8):580-91. PubMed ID: 21319226
[TBL] [Abstract] [Full Text] [Related]
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