Terms: = Lymphoma AND LCK, YT16, 3932, P06239, ENSG00000182866, p56lck, pp58lck AND Treatment
39 results:
1. Dual Targeting of Apoptotic and Signaling Pathways in T-Lineage Acute Lymphoblastic Leukemia.
Saygin C; Giordano G; Shimamoto K; Eisfelder B; Thomas-Toth A; Venkataraman G; Ananthanarayanan V; Vincent TL; DuVall A; Patel AA; Chen Y; Tan F; Anthony SP; Chen Y; Shen Y; Odenike O; Teachey DT; Kee BL; LaBelle J; Stock W
Clin Cancer Res; 2023 Aug; 29(16):3151-3161. PubMed ID: 37363966
[TBL] [Abstract] [Full Text] [Related]
2. Preclinical pharmacokinetic and pharmacodynamic evaluation of dasatinib and ponatinib for the treatment of T-cell acute lymphoblastic leukemia.
Yoshimura S; Panetta JC; Hu J; Li L; Gocho Y; Du G; Umezawa A; Karol SE; Pui CH; Mullighan CG; Konopleva M; Stock W; Teachey DT; Jain N; Yang JJ
Leukemia; 2023 Jun; 37(6):1194-1203. PubMed ID: 37076694
[TBL] [Abstract] [Full Text] [Related]
3. PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120.
Fazio G; Bresolin S; Silvestri D; Quadri M; Saitta C; Vendramini E; Buldini B; Palmi C; Bardini M; Grioni A; Rigamonti S; Galbiati M; Mecca S; Savino AM; Peloso A; Tu JW; Bhatia S; Borkhardt A; Micalizzi C; Lo Nigro L; Locatelli F; Conter V; Rizzari C; Valsecchi MG; Te Kronnie G; Biondi A; Cazzaniga G
EBioMedicine; 2022 Sep; 83():104224. PubMed ID: 35985167
[TBL] [Abstract] [Full Text] [Related]
4. BCR::ABL1 tyrosine kinase inhibitors hamper the therapeutic efficacy of blinatumomab in vitro.
Kauer J; Märklin M; Pflügler M; Hörner S; Hinterleitner C; Tandler C; Jung G; Salih HR; Heitmann JS
J Cancer Res Clin Oncol; 2022 Oct; 148(10):2759-2771. PubMed ID: 35551463
[TBL] [Abstract] [Full Text] [Related]
5. Therapeutic targeting of lck tyrosine kinase and mTOR signaling in T-cell acute lymphoblastic leukemia.
Laukkanen S; Veloso A; Yan C; Oksa L; Alpert EJ; Do D; Hyvärinen N; McCarthy K; Adhikari A; Yang Q; Iyer S; Garcia SP; Pello A; Ruokoranta T; Moisio S; Adhikari S; Yoder JA; Gallagher K; Whelton L; Allen JR; Jin AH; Loontiens S; Heinäniemi M; Kelliher M; Heckman CA; Lohi O; Langenau DM
Blood; 2022 Oct; 140(17):1891-1906. PubMed ID: 35544598
[TBL] [Abstract] [Full Text] [Related]
6. Dasatinib enhances anti-leukemia efficacy of chimeric antigen receptor T cells by inhibiting cell differentiation and exhaustion.
Zhang H; Hu Y; Shao M; Teng X; Jiang P; Wang X; Wang H; Cui J; Yu J; Liang Z; Ding L; Han Y; Wei J; Xu Y; Li X; Shan W; Shi J; Luo Y; Qian P; Huang H
J Hematol Oncol; 2021 Jul; 14(1):113. PubMed ID: 34289897
[TBL] [Abstract] [Full Text] [Related]
7. Novel Targeted Photosensitizer as an Immunomodulator for Highly Efficient Therapy of T-Cell Acute Lymphoblastic Leukemia.
Yuan G; Yao M; Lv H; Jia X; Chen J; Xue J
J Med Chem; 2020 Dec; 63(24):15655-15667. PubMed ID: 33300796
[TBL] [Abstract] [Full Text] [Related]
8. lck expression is a potential biomarker for distinguishing primary central nervous system lymphoma from glioblastoma multiforme.
Ge L; Xu L; Lu S; Yan H
FEBS Open Bio; 2020 May; 10(5):904-911. PubMed ID: 32237064
[TBL] [Abstract] [Full Text] [Related]
9. Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia.
Shi Y; Beckett MC; Blair HJ; Tirtakusuma R; Nakjang S; Enshaei A; Halsey C; Vormoor J; Heidenreich O; Krippner-Heidenreich A; van Delft FW
Haematologica; 2021 Apr; 106(4):1056-1066. PubMed ID: 32139432
[TBL] [Abstract] [Full Text] [Related]
10. Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia.
Akın-Balı DF; Aktas SH; Unal MA; Kankılıc T
Pediatr Hematol Oncol; 2020 Feb; 37(1):58-75. PubMed ID: 31661353
[TBL] [Abstract] [Full Text] [Related]
11. CD28-ζ CAR T Cells Resist TGF-β Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop.
Golumba-Nagy V; Kuehle J; Hombach AA; Abken H
Mol Ther; 2018 Sep; 26(9):2218-2230. PubMed ID: 30055872
[TBL] [Abstract] [Full Text] [Related]
12. Glucocorticoid resistance is reverted by lck inhibition in pediatric T-cell acute lymphoblastic leukemia.
Serafin V; Capuzzo G; Milani G; Minuzzo SA; Pinazza M; Bortolozzi R; Bresolin S; Porcù E; Frasson C; Indraccolo S; Basso G; Accordi B
Blood; 2017 Dec; 130(25):2750-2761. PubMed ID: 29101238
[TBL] [Abstract] [Full Text] [Related]
13. NFAT2 is a critical regulator of the anergic phenotype in chronic lymphocytic leukaemia.
Märklin M; Heitmann JS; Fuchs AR; Truckenmüller FM; Gutknecht M; Bugl S; Saur SJ; Lazarus J; Kohlhofer U; Quintanilla-Martinez L; Rammensee HG; Salih HR; Kopp HG; Haap M; Kirschniak A; Kanz L; Rao A; Wirths S; Müller MR
Nat Commun; 2017 Oct; 8(1):755. PubMed ID: 28970470
[TBL] [Abstract] [Full Text] [Related]
14. Targeting BCL-2 and ABL/LYN in Philadelphia chromosome-positive acute lymphoblastic leukemia.
Leonard JT; Rowley JS; Eide CA; Traer E; Hayes-Lattin B; Loriaux M; Spurgeon SE; Druker BJ; Tyner JW; Chang BH
Sci Transl Med; 2016 Aug; 8(354):354ra114. PubMed ID: 27582059
[TBL] [Abstract] [Full Text] [Related]
15. The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell lymphoma (CTCL).
Litvinov IV; Netchiporouk E; Cordeiro B; Doré MA; Moreau L; Pehr K; Gilbert M; Zhou Y; Sasseville D; Kupper TS
Clin Cancer Res; 2015 Jun; 21(12):2820-9. PubMed ID: 25779945
[TBL] [Abstract] [Full Text] [Related]
16. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells.
Chang CH; Wang Y; Gupta P; Goldenberg DM
MAbs; 2015; 7(1):199-211. PubMed ID: 25484043
[TBL] [Abstract] [Full Text] [Related]
17. Cooperativity of CD44 and CD49d in leukemia cell homing, migration, and survival offers a means for therapeutic attack.
Singh V; Erb U; Zöller M
J Immunol; 2013 Nov; 191(10):5304-16. PubMed ID: 24127558
[TBL] [Abstract] [Full Text] [Related]
18. Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells.
Robles-Escajeda E; Lerma D; Nyakeriga AM; Ross JA; Kirken RA; Aguilera RJ; Varela-Ramirez A
PLoS One; 2013; 8(9):e73508. PubMed ID: 24039967
[TBL] [Abstract] [Full Text] [Related]
19. NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the lck kinase and various interacting proteins.
De Keersmaecker K; Porcu M; Cox L; Girardi T; Vandepoel R; de Beeck JO; Gielen O; Mentens N; Bennett KL; Hantschel O
Haematologica; 2014 Jan; 99(1):85-93. PubMed ID: 23872305
[TBL] [Abstract] [Full Text] [Related]
20. Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype.
Joosten M; Seitz V; Zimmermann K; Sommerfeld A; Berg E; Lenze D; Leser U; Stein H; Hummel M
Haematologica; 2013 Feb; 98(2):247-54. PubMed ID: 22899583
[TBL] [Abstract] [Full Text] [Related]
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