Terms: = Pancreatic cancer AND MAP2K4, MEK4, 6416, P45985, ENSG00000065559, SERK1, JNKK1, MKK4, PRKMK4, MAPKK4, JNKK, SEK1
25 results:
1. In silico identification and biological evaluation of a selective MAP4K4 inhibitor against pancreatic cancer.
Chang CD; Chao MW; Lee HY; Liu YT; Tu HJ; Lien ST; Lin TE; Sung TY; Yen SC; Huang SH; Hsu KC; Pan SL
J Enzyme Inhib Med Chem; 2023 Dec; 38(1):2166039. PubMed ID: 36683274
[TBL] [Abstract] [Full Text] [Related]
2. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a radiomic model to predict tumor grade.
Chiti G; Grazzini G; Flammia F; Matteuzzi B; Tortoli P; Bettarini S; Pasqualini E; Granata V; Busoni S; Messserini L; Pradella S; Massi D; Miele V
Radiol Med; 2022 Sep; 127(9):928-938. PubMed ID: 35917099
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3. A new prognosis prediction model combining TNM stage with map2k4 and JNK in postoperative pancreatic cancer patients.
Liu XD; Zhang ZW; Wu HW; Liang ZY
Pathol Res Pract; 2021 Jan; 217():153313. PubMed ID: 33341545
[TBL] [Abstract] [Full Text] [Related]
4. Selective activation of tumor-suppressive MAPKP signaling pathway by triptonide effectively inhibits pancreatic cancer cell tumorigenicity and tumor growth.
Zhang B; Meng M; Xiang S; Cao Z; Xu X; Zhao Z; Zhang T; Chen B; Yang P; Li Y; Zhou Q
Biochem Pharmacol; 2019 Aug; 166():70-81. PubMed ID: 31075266
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5. Clinicopathological and prognostic significance of mkk4 and MKK7 in resectable pancreatic ductal adenocarcinoma.
Lu J; Zhou L; Yang G; Liang ZY; Zhou WX; You L; Yuan D; Li BQ; Guo JC; Zhao YP
Hum Pathol; 2019 Apr; 86():143-154. PubMed ID: 30537492
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6. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer.
Genovese G; Carugo A; Tepper J; Robinson FS; Li L; Svelto M; Nezi L; Corti D; Minelli R; Pettazzoni P; Gutschner T; Wu CC; Seth S; Akdemir KC; Leo E; Amin S; Molin MD; Ying H; Kwong LN; Colla S; Takahashi K; Ghosh P; Giuliani V; Muller F; Dey P; Jiang S; Garvey J; Liu CG; Zhang J; Heffernan TP; Toniatti C; Fleming JB; Goggins MG; Wood LD; Sgambato A; Agaimy A; Maitra A; Roberts CW; Wang H; Viale A; DePinho RA; Draetta GF; Chin L
Nature; 2017 Feb; 542(7641):362-366. PubMed ID: 28178232
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7. LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and map2k4.
Liu J; Xu D; Wang Q; Zheng D; Jiang X; Xu L
Dig Dis Sci; 2014 Jul; 59(7):1452-60. PubMed ID: 24532253
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8. Methylation-mediated silencing of the miR-124 genes facilitates pancreatic cancer progression and metastasis by targeting Rac1.
Wang P; Chen L; Zhang J; Chen H; Fan J; Wang K; Luo J; Chen Z; Meng Z; Liu L
Oncogene; 2014 Jan; 33(4):514-24. PubMed ID: 23334332
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9. Identification of common variants in BRCA2 and map2k4 for susceptibility to sporadic pancreatic cancer.
Huang L; Wu C; Yu D; Wang C; Che X; Miao X; Zhai K; Chang J; Jiang G; Yang X; Cao G; Hu Z; Zhou Y; Zuo C; Wang C; Zhang X; Zhou Y; Yu X; Dai W; Li Z; Shen H; Liu L; Chen Y; Zhang S; Wang X; Liu Y; Sun M; Cao W; Gao J; Ma Y; Zheng X; Cheung ST; Jia Y; Tan W; Wu T; Lin D
Carcinogenesis; 2013 May; 34(5):1001-5. PubMed ID: 23299404
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10. pancreatic cancer genomes reveal aberrations in axon guidance pathway genes.
Biankin AV; Waddell N; Kassahn KS; Gingras MC; Muthuswamy LB; Johns AL; Miller DK; Wilson PJ; Patch AM; Wu J; Chang DK; Cowley MJ; Gardiner BB; Song S; Harliwong I; Idrisoglu S; Nourse C; Nourbakhsh E; Manning S; Wani S; Gongora M; Pajic M; Scarlett CJ; Gill AJ; Pinho AV; Rooman I; Anderson M; Holmes O; Leonard C; Taylor D; Wood S; Xu Q; Nones K; Fink JL; Christ A; Bruxner T; Cloonan N; Kolle G; Newell F; Pinese M; Mead RS; Humphris JL; Kaplan W; Jones MD; Colvin EK; Nagrial AM; Humphrey ES; Chou A; Chin VT; Chantrill LA; Mawson A; Samra JS; Kench JG; Lovell JA; Daly RJ; Merrett ND; Toon C; Epari K; Nguyen NQ; Barbour A; Zeps N; ; Kakkar N; Zhao F; Wu YQ; Wang M; Muzny DM; Fisher WE; Brunicardi FC; Hodges SE; Reid JG; Drummond J; Chang K; Han Y; Lewis LR; Dinh H; Buhay CJ; Beck T; Timms L; Sam M; Begley K; Brown A; Pai D; Panchal A; Buchner N; De Borja R; Denroche RE; Yung CK; Serra S; Onetto N; Mukhopadhyay D; Tsao MS; Shaw PA; Petersen GM; Gallinger S; Hruban RH; Maitra A; Iacobuzio-Donahue CA; Schulick RD; Wolfgang CL; Morgan RA; Lawlor RT; Capelli P; Corbo V; Scardoni M; Tortora G; Tempero MA; Mann KM; Jenkins NA; Perez-Mancera PA; Adams DJ; Largaespada DA; Wessels LF; Rust AG; Stein LD; Tuveson DA; Copeland NG; Musgrove EA; Scarpa A; Eshleman JR; Hudson TJ; Sutherland RL; Wheeler DA; Pearson JV; McPherson JD; Gibbs RA; Grimmond SM
Nature; 2012 Nov; 491(7424):399-405. PubMed ID: 23103869
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11. Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis.
Pramanik KC; Srivastava SK
Antioxid Redox Signal; 2012 Nov; 17(10):1417-32. PubMed ID: 22530568
[TBL] [Abstract] [Full Text] [Related]
12. Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma.
Mann KM; Ward JM; Yew CC; Kovochich A; Dawson DW; Black MA; Brett BT; Sheetz TE; Dupuy AJ; ; Chang DK; Biankin AV; Waddell N; Kassahn KS; Grimmond SM; Rust AG; Adams DJ; Jenkins NA; Copeland NG
Proc Natl Acad Sci U S A; 2012 Apr; 109(16):5934-41. PubMed ID: 22421440
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13. Biological and prognostic relevance of mitogen-activated protein kinases in pancreatic adenocarcinoma.
Handra-Luca A; Lesty C; Hammel P; Sauvanet A; Rebours V; Martin A; Fagard R; Fléjou JF; Faivre S; Bédossa P; Ruszniewski P; Couvelard A
Pancreas; 2012 Apr; 41(3):416-21. PubMed ID: 22158075
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14. Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells.
Kreutzer JN; Ruzzene M; Guerra B
BMC Cancer; 2010 Aug; 10():440. PubMed ID: 20718998
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15. Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells.
Kisfalvi K; Hurd C; Guha S; Rozengurt E
J Cell Physiol; 2010 May; 223(2):309-16. PubMed ID: 20082306
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16. The pathology and genetics of metastatic pancreatic cancer.
Yachida S; Iacobuzio-Donahue CA
Arch Pathol Lab Med; 2009 Mar; 133(3):413-22. PubMed ID: 19260747
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17. Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors.
Couvelard A; Hu J; Steers G; O'Toole D; Sauvanet A; Belghiti J; Bedossa P; Gatter K; Ruszniewski P; Pezzella F
Gastroenterology; 2006 Nov; 131(5):1597-610. PubMed ID: 17064702
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18. Targeted deletion of mkk4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss.
Cunningham SC; Gallmeier E; Hucl T; Dezentje DA; Calhoun ES; Falco G; Abdelmohsen K; Gorospe M; Kern SE
Cancer Res; 2006 Jun; 66(11):5560-4. PubMed ID: 16740690
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19. map2k4/mkk4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course.
Xin W; Yun KJ; Ricci F; Zahurak M; Qiu W; Su GH; Yeo CJ; Hruban RH; Kern SE; Iacobuzio-Donahue CA
Clin Cancer Res; 2004 Dec; 10(24):8516-20. PubMed ID: 15623633
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20. Evidence of mkk4 pro-oncogenic activity in breast and pancreatic tumors.
Wang L; Pan Y; Dai JL
Oncogene; 2004 Aug; 23(35):5978-85. PubMed ID: 15184866
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