Terms: = Pancreatic cancer AND PIM1, PIM, 5292, ENSG00000137193, P11309 AND Treatment
19 results:
1. AUM302, a novel triple kinase pim/PI3K/mTOR inhibitor, is a potent in vitro pancreatic cancer growth inhibitor.
Ingle K; LaComb JF; Graves LM; Baines AT; Bialkowska AB
PLoS One; 2023; 18(11):e0294065. PubMed ID: 37943821
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2. Targeting macrophagic pim-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl
Zhang Z; Xie S; Qian J; Gao F; Jin W; Wang L; Yan L; Chen H; Yao W; Li M; Wang X; Zhu L
J Transl Med; 2023 Jul; 21(1):452. PubMed ID: 37422640
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3. LncRNA RGMB-AS1 facilitates pancreatic cancer cell proliferation and migration but inhibits cell apoptosis via miR-574-3p/pim3 axis.
Song W; Shi C
Am J Physiol Gastrointest Liver Physiol; 2021 Nov; 321(5):G477-G488. PubMed ID: 34468207
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4. DCE-MRI of Sunitinib-Induced Changes in Tumor Microvasculature and Hypoxia: A Study of pancreatic Ductal Adenocarcinoma Xenografts.
Wegner CS; Hauge A; Simonsen TG; Gaustad JV; Andersen LMK; Rofstad EK
Neoplasia; 2018 Jul; 20(7):734-744. PubMed ID: 29886124
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5. pim-1 contributes to the malignancy of pancreatic cancer and displays diagnostic and prognostic value.
Xu J; Xiong G; Cao Z; Huang H; Wang T; You L; Zhou L; Zheng L; Hu Y; Zhang T; Zhao Y
J Exp Clin Cancer Res; 2016 Sep; 35(1):133. PubMed ID: 27596051
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6. pim-3 contributes to radioresistance through regulation of the cell cycle and DNA damage repair in pancreatic cancer cells.
Chen XY; Wang Z; Li B; Zhang YJ; Li YY
Biochem Biophys Res Commun; 2016 Apr; 473(1):296-302. PubMed ID: 27016481
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7. MicroRNA‑506 participates in pancreatic cancer pathogenesis by targeting pim3.
Du J; Zheng X; Cai S; Zhu Z; Tan J; Hu B; Huang Z; Jiao H
Mol Med Rep; 2015 Oct; 12(4):5121-6. PubMed ID: 26238203
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8. Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation.
Lin F; Luo X; Tsun A; Li Z; Li D; Li B
Int Immunopharmacol; 2015 Oct; 28(2):859-65. PubMed ID: 25870037
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9. Calix[6]arene bypasses human pancreatic cancer aggressiveness: downregulation of receptor tyrosine kinases and induction of cell death by reticulum stress and autophagy.
Pelizzaro-Rocha KJ; de Jesus MB; Ruela-de-Sousa RR; Nakamura CV; Reis FS; de Fátima A; Ferreira-Halder CV
Biochim Biophys Acta; 2013 Dec; 1833(12):2856-2865. PubMed ID: 23872419
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10. Inhibition of oncogenic pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.
Xu D; Cobb MG; Gavilano L; Witherspoon SM; Williams D; White CD; Taverna P; Bednarski BK; Kim HJ; Baldwin AS; Baines AT
Cancer Biol Ther; 2013 Jun; 14(6):492-501. PubMed ID: 23760491
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11. Conditional transgenic expression of pim1 kinase in prostate induces inflammation-dependent neoplasia.
Narlik-Grassow M; Blanco-Aparicio C; Cecilia Y; Perez M; Muñoz-Galvan S; Cañamero M; Renner O; Carnero A
PLoS One; 2013; 8(4):e60277. PubMed ID: 23565217
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12. T-18, a stemonamide synthetic intermediate inhibits pim kinase activity and induces cell apoptosis, acting as a potent anticancer drug.
Wang Z; Li XM; Shang K; Zhang P; Wang CF; Xin YH; Zhou L; Li YY
Oncol Rep; 2013 Mar; 29(3):1245-51. PubMed ID: 23314349
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13. IL-6 stimulates STAT3 and pim-1 kinase in pancreatic cancer cell lines.
Block KM; Hanke NT; Maine EA; Baker AF
Pancreas; 2012 Jul; 41(5):773-81. PubMed ID: 22273698
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14. Identification of a phenanthrene derivative as a potent anticancer drug with pim kinase inhibitory activity.
Wang YY; Taniguchi T; Baba T; Li YY; Ishibashi H; Mukaida N
Cancer Sci; 2012 Jan; 103(1):107-15. PubMed ID: 21981263
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15. The oncogenic kinase pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.
Xu D; Allsop SA; Witherspoon SM; Snider JL; Yeh JJ; Fiordalisi JJ; White CD; Williams D; Cox AD; Baines AT
Carcinogenesis; 2011 Apr; 32(4):488-95. PubMed ID: 21262926
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16. pim kinase inhibitors downregulate STAT3(Tyr705) phosphorylation.
Chang M; Kanwar N; Feng E; Siu A; Liu X; Ma D; Jongstra J
Mol Cancer Ther; 2010 Sep; 9(9):2478-87. PubMed ID: 20667852
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17. Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability.
Li YY; Wang YY; Taniguchi T; Kawakami T; Baba T; Ishibashi H; Mukaida N
Int J Cancer; 2010 Jul; 127(2):474-84. PubMed ID: 19921695
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18. [Effect of ginsenoside Rg3 on pim-3 and Bad proteins in human pancreatic cancer cell line PANC-1].
Jian J; Hu ZF; Huang Y
Ai Zheng; 2009 May; 28(5):461-5. PubMed ID: 19624871
[TBL] [Abstract] [Full Text] [Related]
19. pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines.
Li YY; Popivanova BK; Nagai Y; Ishikura H; Fujii C; Mukaida N
Cancer Res; 2006 Jul; 66(13):6741-7. PubMed ID: 16818649
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