Terms: = Pancreatic cancer AND PTCH1, RP11-435O5_3, Q13635, PTCH, 5727, HPE7, FLJ26746, NBCCS, BCNS, PTC1, ENSG00000185920, FLJ42602 AND Treatment
22 results:
1. 2‑Cl‑IB‑MECA regulates the proliferative and drug resistance pathways, and facilitates chemosensitivity in pancreatic and liver cancer cell lines.
Kotulova J; Lonova K; Kubickova A; Vrbkova J; Kourilova P; Hajduch M; Dzubak P
Int J Mol Med; 2022 Mar; 49(3):. PubMed ID: 35039871
[TBL] [Abstract] [Full Text] [Related]
2. TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Zhu R; Gires O; Zhu L; Liu J; Li J; Yang H; Ju G; Huang J; Ge W; Chen Y; Lu Z; Wang H
Nat Commun; 2019 Jun; 10(1):2863. PubMed ID: 31253779
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3. Genomic testing, tumor microenvironment and targeted therapy of Hedgehog-related human cancers.
Katoh M
Clin Sci (Lond); 2019 Apr; 133(8):953-970. PubMed ID: 31036756
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4. The role of the Hedgehog signaling pathway in cancer: A comprehensive review.
Skoda AM; Simovic D; Karin V; Kardum V; Vranic S; Serman L
Bosn J Basic Med Sci; 2018 Feb; 18(1):8-20. PubMed ID: 29274272
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5. Sunitinib in the treatment of Thyroid cancer.
Ferrari SM; Centanni M; Virili C; Miccoli M; Ferrari P; Ruffilli I; Ragusa F; Antonelli A; Fallahi P
Curr Med Chem; 2019; 26(6):963-972. PubMed ID: 28990511
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6. Efficient Synthesis of Heterocyclic Flavonoids with Hedgehog Signal Inhibitory Activity.
Arai MA; Utsumi T; Yanase N; Fujimatsu T; Ishibashi M
Chem Pharm Bull (Tokyo); 2017; 65(8):784-795. PubMed ID: 28768932
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7. Hedgehog pathway overexpression in pancreatic cancer is abrogated by new-generation taxoid SB-T-1216.
Mohelnikova-Duchonova B; Kocik M; Duchonova B; Brynychova V; Oliverius M; Hlavsa J; Honsova E; Mazanec J; Kala Z; Ojima I; Hughes DJ; Doherty JE; Murray HA; Crockard MA; Lemstrova R; Soucek P
Pharmacogenomics J; 2017 Oct; 17(5):452-460. PubMed ID: 27573236
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8. Ormeloxifene suppresses desmoplasia and enhances sensitivity of gemcitabine in pancreatic cancer.
Khan S; Ebeling MC; Chauhan N; Thompson PA; Gara RK; Ganju A; Yallapu MM; Behrman SW; Zhao H; Zafar N; Singh MM; Jaggi M; Chauhan SC
Cancer Res; 2015 Jun; 75(11):2292-304. PubMed ID: 25840985
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9. The Hedgehog pathway: role in cell differentiation, polarity and proliferation.
Jia Y; Wang Y; Xie J
Arch Toxicol; 2015 Feb; 89(2):179-91. PubMed ID: 25559776
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10. Pilot clinical trial of hedgehog pathway inhibitor GDC-0449 (vismodegib) in combination with gemcitabine in patients with metastatic pancreatic adenocarcinoma.
Kim EJ; Sahai V; Abel EV; Griffith KA; Greenson JK; Takebe N; Khan GN; Blau JL; Craig R; Balis UG; Zalupski MM; Simeone DM
Clin Cancer Res; 2014 Dec; 20(23):5937-5945. PubMed ID: 25278454
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11. Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may involve inhibition of the Hedgehog signaling pathway.
Qin Y; Ma Z; Dang X; Li W; Ma Q
Mol Med Rep; 2014 Nov; 10(5):2563-7. PubMed ID: 25190613
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12. Perifosine inhibits S6K1-Gli1 signaling and enhances gemcitabine-induced anti-pancreatic cancer efficiency.
Xin Y; Shen XD; Cheng L; Hong DF; Chen B
Cancer Chemother Pharmacol; 2014 Apr; 73(4):711-9. PubMed ID: 24519751
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13. Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1.
Götschel F; Berg D; Gruber W; Bender C; Eberl M; Friedel M; Sonntag J; Rüngeler E; Hache H; Wierling C; Nietfeld W; Lehrach H; Frischauf A; Schwartz-Albiez R; Aberger F; Korf U
PLoS One; 2013; 8(6):e65403. PubMed ID: 23762360
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14. Resveratrol inhibits proliferation and induces apoptosis through the hedgehog signaling pathway in pancreatic cancer cell.
Mo W; Xu X; Xu L; Wang F; Ke A; Wang X; Guo C
Pancreatology; 2011; 11(6):601-9. PubMed ID: 22301921
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15. Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.
Bahra M; Kamphues C; Boas-Knoop S; Lippert S; Esendik U; Schüller U; Hartmann W; Waha A; Neuhaus P; Heppner F; Pietsch T; Koch A
Pancreas; 2012 Mar; 41(2):222-9. PubMed ID: 22076568
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16. Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors.
Rifai Y; Arai MA; Koyano T; Kowithayakorn T; Ishibashi M
J Nat Prod; 2010 May; 73(5):995-7. PubMed ID: 20450170
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17. Diagnosis and treatment of pancreatic metastases of a papillary thyroid carcinoma.
Borschitz T; Eichhorn W; Fottner C; Hansen T; Schad A; Schadmand-Fischer S; Weber MM; Schreckenberger M; Lang H; Musholt TJ
Thyroid; 2010 Jan; 20(1):93-8. PubMed ID: 20025539
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18. Expression and regulation of hedgehog signaling pathway in pancreatic cancer.
Yang Y; Tian X; Xie X; Zhuang Y; Wu W; Wang W
Langenbecks Arch Surg; 2010 Jun; 395(5):515-25. PubMed ID: 19396459
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19. An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.
Feldmann G; Fendrich V; McGovern K; Bedja D; Bisht S; Alvarez H; Koorstra JB; Habbe N; Karikari C; Mullendore M; Gabrielson KL; Sharma R; Matsui W; Maitra A
Mol Cancer Ther; 2008 Sep; 7(9):2725-35. PubMed ID: 18790753
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20. Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review).
Katoh Y; Katoh M
Int J Mol Med; 2006 Dec; 18(6):1019-23. PubMed ID: 17089004
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