Terms: = Pancreatic cancer AND PTPN11, CFC, Q06124, 5781, ENSG00000179295, SHP2, MGC14433, SHP-2, BPTP3, PTP-1D, SH-PTP3, NS1, SH-PTP2, PTP2C
53 results:
1. Undiagnosed RASopathies in infertile men.
Juchnewitsch AG; Pomm K; Dutta A; Tamp E; Valkna A; Lillepea K; Mahyari E; Tjagur S; Belova G; Kübarsepp V; Castillo-Madeen H; Riera-Escamilla A; Põlluaas L; Nagirnaja L; Poolamets O; Vihljajev V; Sütt M; Versbraegen N; Papadimitriou S; McLachlan RI; Jarvi KA; Schlegel PN; Tennisberg S; Korrovits P; Vigh-Conrad K; O'Bryan MK; Aston KI; Lenaerts T; Conrad DF; Kasak L; Punab M; Laan M
Front Endocrinol (Lausanne); 2024; 15():1312357. PubMed ID: 38654924
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2. Tyrosine phosphatase
Chen X; Keller SJ; Hafner P; Alrawashdeh AY; Avery TY; Norona J; Zhou J; Ruess DA
Front Immunol; 2024; 15():1340726. PubMed ID: 38504984
[TBL] [Abstract] [Full Text] [Related]
3. Inhibition of the RAF/MEK/ERK Signaling Cascade in pancreatic cancer: Recent Advances and Future Perspectives.
Adamopoulos C; Cave DD; Papavassiliou AG
Int J Mol Sci; 2024 Jan; 25(3):. PubMed ID: 38338909
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4. Multiple medicinal chemistry strategies of targeting KRAS: State-of-the art and future directions.
Shang Y; Fu S; Hao Q; Ying H; Wang J; Shen T
Bioorg Chem; 2024 Mar; 144():107092. PubMed ID: 38271825
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5. Unveiling the role of KRAS in tumor immune microenvironment.
Xu M; Zhao X; Wen T; Qu X
Biomed Pharmacother; 2024 Feb; 171():116058. PubMed ID: 38171240
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6. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based shp2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant cancers.
Hou Q; Jiang W; Li W; Huang C; Yang K; Chen X; Huang M; Shu C; Luo G; Sun H; Chu Q; Wu X
J Med Chem; 2023 Oct; 66(19):13646-13664. PubMed ID: 37754066
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7. shp2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Drilon A; Sharma MR; Johnson ML; Yap TA; Gadgeel S; Nepert D; Feng G; Reddy MB; Harney AS; Elsayed M; Cook AW; Wong CE; Hinklin RJ; Jiang Y; Brown EN; Neitzel NA; Laird ER; Wu WI; Singh A; Wei P; Ching KA; Gaudino JJ; Lee PA; Hartley DP; Rothenberg SM
Cancer Discov; 2023 Aug; 13(8):1789-1801. PubMed ID: 37269335
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8. Targeting KRAS in pancreatic cancer: Emerging therapeutic strategies.
Khan S; Budamagunta V; Zhou D
Adv Cancer Res; 2023; 159():145-184. PubMed ID: 37268395
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9. Major Venous Repair or Reconstruction During Laparoscopic pancreatic Surgery: A Single Center's Experience.
Jie Z; Zhou X; Haibiao W; Ying D; Chen B; Li H
J Laparoendosc Adv Surg Tech A; 2023 Sep; 33(9):890-896. PubMed ID: 37074117
[No Abstract] [Full Text] [Related]
10. miR-6071 inhibits hepatocellular carcinoma progression via targeting ptpn11.
Chen M; Wang H; Shi S; Zhang H; Xu S; Jiang Y
Arch Biochem Biophys; 2022 Sep; 727():109345. PubMed ID: 35792156
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11. Human Norovirus Triggers Primary B Cell Immune Activation
Mirabelli C; Jones MK; Young VL; Kolawole AO; Owusu I; Shan M; Abuaita B; Turula H; Trevino JG; Grigorova I; Lundy SK; Lyssiotis CA; Ward VK; Karst SM; Wobus CE
mBio; 2022 Apr; 13(2):e0017522. PubMed ID: 35404121
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12. Structure-based discovery of a specific shp2 inhibitor with enhanced blood-brain barrier penetration from PubChem database.
Ma Y; Li WY; Sun T; Zhang L; Lu XH; Yang B; Wang RL
Bioorg Chem; 2022 Apr; 121():105648. PubMed ID: 35180489
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13. Prognostic significance of shp2 (ptpn11) expression in solid tumors: A meta-analysis.
Zhou J; Guo H; Zhang Y; Liu H; Dou Q
PLoS One; 2022; 17(1):e0262931. PubMed ID: 35061863
[TBL] [Abstract] [Full Text] [Related]
14. Targeting the KRAS α4-α5 allosteric interface inhibits pancreatic cancer tumorigenesis.
Khan I; Marelia-Bennet C; Lefler J; Zuberi M; Denbaum E; Koide A; Connor DM; Broome AM; Pécot T; Timmers C; Ostrowski MC; Koide S; O'Bryan JP
Small GTPases; 2022 Jan; 13(1):114-127. PubMed ID: 33949915
[No Abstract] [Full Text] [Related]
15. Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation.
Buday L; Vas V
Cancer Metastasis Rev; 2020 Dec; 39(4):1067-1073. PubMed ID: 32936431
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16.
Valencia-Sama I; Ladumor Y; Kee L; Adderley T; Christopher G; Robinson CM; Kano Y; Ohh M; Irwin MS
Cancer Res; 2020 Aug; 80(16):3413-3423. PubMed ID: 32586982
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17. Defining and Targeting Adaptations to Oncogenic KRAS
Santana-Codina N; Chandhoke AS; Yu Q; Małachowska B; Kuljanin M; Gikandi A; Stańczak M; Gableske S; Jedrychowski MP; Scott DA; Aguirre AJ; Fendler W; Gray NS; Mancias JD
Cell Rep; 2020 Mar; 30(13):4584-4599.e4. PubMed ID: 32234489
[TBL] [Abstract] [Full Text] [Related]
18. Diagnostic performance of endoscopic ultrasound through-the-needle microforceps biopsy of pancreatic cystic lesions: Systematic review with meta-analysis.
Tacelli M; Celsa C; Magro B; Barchiesi M; Barresi L; Capurso G; Arcidiacono PG; Cammà C; Crinò SF
Dig Endosc; 2020 Nov; 32(7):1018-1030. PubMed ID: 31912580
[TBL] [Abstract] [Full Text] [Related]
19. shp2 Inhibition Overcomes RTK-Mediated Pathway Reactivation in KRAS-Mutant Tumors Treated with MEK Inhibitors.
Lu H; Liu C; Velazquez R; Wang H; Dunkl LM; Kazic-Legueux M; Haberkorn A; Billy E; Manchado E; Brachmann SM; Moody SE; Engelman JA; Hammerman PS; Caponigro G; Mohseni M; Hao HX
Mol Cancer Ther; 2019 Jul; 18(7):1323-1334. PubMed ID: 31068384
[TBL] [Abstract] [Full Text] [Related]
20. Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Kano Y; Gebregiworgis T; Marshall CB; Radulovich N; Poon BPK; St-Germain J; Cook JD; Valencia-Sama I; Grant BMM; Herrera SG; Miao J; Raught B; Irwin MS; Lee JE; Yeh JJ; Zhang ZY; Tsao MS; Ikura M; Ohh M
Nat Commun; 2019 Jan; 10(1):224. PubMed ID: 30644389
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