Terms: = Pancreatic cancer AND RAF1, Raf-1, 5894, P04049, ENSG00000132155, c-Raf, CRAF AND Treatment
35 results:
1. Disruption of the pro-oncogenic c-raf-PDE8A complex represents a differentiated approach to treating KRAS-c-raf dependent PDAC.
Cooke SF; Wright TA; Sin YY; Ling J; Kyurkchieva E; Phanthaphol N; Mcskimming T; Herbert K; Rebus S; Biankin AV; Chang DK; Baillie GS; Blair CM
Sci Rep; 2024 Apr; 14(1):8998. PubMed ID: 38637546
[TBL] [Abstract] [Full Text] [Related]
2. Discovery of KRB-456, a KRAS G12D Switch-I/II Allosteric Pocket Binder That Inhibits the Growth of pancreatic cancer Patient-derived Tumors.
Kazi A; Ranjan A; Kumar M V V; Agianian B; Garcia Chavez M; Vudatha V; Wang R; Vangipurapu R; Chen L; Kennedy P; Subramanian K; Quirke JCK; Beato F; Underwood PW; Fleming JB; Trevino J; Hergenrother PJ; Gavathiotis E; Sebti SM
Cancer Res Commun; 2023 Dec; 3(12):2623-2639. PubMed ID: 38051103
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3. Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy.
Montenegro MF; Martí-Díaz R; Navarro A; Tolivia J; Sánchez-Del-Campo L; Cabezas-Herrera J; Rodríguez-López JN
Cell Death Dis; 2023 Nov; 14(11):761. PubMed ID: 37996408
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4. α4-α5 Helices on Surface of KRAS Can Accommodate Small Compounds That Increase KRAS Signaling While Inducing CRC Cell Death.
Abuasaker B; Garrido E; Vilaplana M; Gómez-Zepeda JD; Brun S; Garcia-Cajide M; Mauvezin C; Jaumot M; Pujol MD; Rubio-Martínez J; Agell N
Int J Mol Sci; 2023 Jan; 24(1):. PubMed ID: 36614192
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5. Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma: A case report and review of literature.
Lee CL; Holter S; Borgida A; Dodd A; Ramotar S; Grant R; Wasson K; Elimova E; Jang RW; Moore M; Kim TK; Khalili K; Moulton CA; Gallinger S; O'Kane GM; Knox JJ
World J Gastroenterol; 2022 Dec; 28(45):6421-6432. PubMed ID: 36533108
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6. Anticancer drug resistance: An update and perspective.
Nussinov R; Tsai CJ; Jang H
Drug Resist Updat; 2021 Dec; 59():100796. PubMed ID: 34953682
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7. DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the pancreatic Tumor Microenvironment.
Nakkina SP; Gitto SB; Beardsley JM; Pandey V; Rohr MW; Parikh JG; Phanstiel O; Altomare DA
Int J Mol Sci; 2021 Dec; 22(24):. PubMed ID: 34947972
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8. LncRNA CERS6-AS1 promotes proliferation and metastasis through the upregulation of YWHAG and activation of ERK signaling in pancreatic cancer.
Xu J; Wang J; He Z; Chen P; Jiang X; Chen Y; Liu X; Jiang J
Cell Death Dis; 2021 Jun; 12(7):648. PubMed ID: 34168120
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9. HIF-1α and RKIP: a computational approach for pancreatic cancer therapy.
Srivani G; Behera SK; Dariya B; Chalikonda G; Alam A; Nagaraju GP
Mol Cell Biochem; 2020 Sep; 472(1-2):95-103. PubMed ID: 32562168
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10. Dihydrosanguinarine suppresses pancreatic cancer cells via regulation of mut-p53/WT-p53 and the Ras/Raf/Mek/Erk pathway.
Wu SZ; Xu HC; Wu XL; Liu P; Shi YC; Pang P; Deng L; Zhou GX; Chen XY
Phytomedicine; 2019 Jun; 59():152895. PubMed ID: 30913453
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11. A novel tricarbonylmethane agent (CMC2.24) reduces human pancreatic tumor growth in mice by targeting Ras.
Mallangada NA; Vargas JM; Thomas S; DiGiovanni MG; Vaeth BM; Nemesure MD; Wang R; LaComb JF; Williams JL; Golub LM; Johnson F; Mackenzie GG
Mol Carcinog; 2018 Sep; 57(9):1130-1143. PubMed ID: 29683208
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12. Identification of gene expression models for laryngeal squamous cell carcinoma using co-expression network analysis.
Yang CW; Wang SF; Yang XL; Wang L; Niu L; Liu JX
Medicine (Baltimore); 2018 Feb; 97(7):e9738. PubMed ID: 29443735
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13. Cholinergic receptors as target for cancer therapy in a systems medicine perspective.
Russo P; Del Bufalo A; Milic M; Salinaro G; Fini M; Cesario A
Curr Mol Med; 2014; 14(9):1126-38. PubMed ID: 25324001
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14. Knockdown or inhibition of aldo-keto reductase 1B10 inhibits pancreatic carcinoma growth via modulating Kras-E-cadherin pathway.
Zhang W; Li H; Yang Y; Liao J; Yang GY
Cancer Lett; 2014 Dec; 355(2):273-80. PubMed ID: 25304374
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15. The molecular mechanisms of a novel multi-kinase inhibitor ZLJ33 in suppressing pancreatic cancer growth.
Li Y; Tang K; Zhang L; Li C; Niu F; Zhou W; Yang H; Feng Z; Chen X
Cancer Lett; 2015 Jan; 356(2 Pt B):392-403. PubMed ID: 25301453
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16. Comprehensive genomic profiling of pancreatic acinar cell carcinomas identifies recurrent RAF fusions and frequent inactivation of DNA repair genes.
Chmielecki J; Hutchinson KE; Frampton GM; Chalmers ZR; Johnson A; Shi C; Elvin J; Ali SM; Ross JS; Basturk O; Balasubramanian S; Lipson D; Yelensky R; Pao W; Miller VA; Klimstra DS; Stephens PJ
Cancer Discov; 2014 Dec; 4(12):1398-405. PubMed ID: 25266736
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17. Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice.
Xiao Z; Li L; Li Y; Zhou W; Cheng J; Liu F; Zheng P; Zhang Y; Che Y
Cell Death Dis; 2014 May; 5(5):e1241. PubMed ID: 24853419
[TBL] [Abstract] [Full Text] [Related]
18. Targeting the prohibitin scaffold-craf kinase interaction in RAS-ERK-driven pancreatic ductal adenocarcinoma.
Luan Z; He Y; Alattar M; Chen Z; He F
Mol Cancer; 2014 Feb; 13():38. PubMed ID: 24568222
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19. [Mechanism underlying pancreatic cancer cell resistance to mTOR inhibitor RAD001 via c-raf/ERK1/2 activation].
Wei F; Zhang P; Qi J; Wang M; Wang G
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi; 2014 Jan; 30(1):23-7. PubMed ID: 24405594
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20. A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.
Mackenzie GG; Bartels LE; Xie G; Papayannis I; Alston N; Vrankova K; Ouyang N; Rigas B
Neoplasia; 2013 Oct; 15(10):1184-95. PubMed ID: 24204197
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