Terms: = Pancreatic cancer AND uPA AND Treatment
31 results:
1. Circulating tumor DNA in unresectable pancreatic cancer is a strong predictor of first-line treatment efficacy: The KRASCIPANC prospective study.
Evrard C; Ingrand P; Rochelle T; Martel M; Tachon G; Flores N; Randrian V; Ferru A; Haineaux PA; Goujon JM; Karayan-Tapon L; Tougeron D
Dig Liver Dis; 2023 Nov; 55(11):1562-1572. PubMed ID: 37308396
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2. Urokinase plasminogen activator induces epithelial-mesenchymal and metastasis of pancreatic cancer through plasmin/MMP14/TGF-β axis, which is inhibited by 4-acetyl-antroquinonol B treatment.
Wu CZ; Chu YC; Lai SW; Hsieh MS; Yadav VK; Fong IH; Deng L; Huang CC; Tzeng YM; Yeh CT; Chen JS
Phytomedicine; 2022 Jun; 100():154062. PubMed ID: 35366491
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3. STARD1 promotes NASH-driven HCC by sustaining the generation of bile acids through the alternative mitochondrial pathway.
Conde de la Rosa L; Garcia-Ruiz C; Vallejo C; Baulies A; Nuñez S; Monte MJ; Marin JJG; Baila-Rueda L; Cenarro A; Civeira F; Fuster J; Garcia-Valdecasas JC; Ferrer J; Karin M; Ribas V; Fernandez-Checa JC
J Hepatol; 2021 Jun; 74(6):1429-1441. PubMed ID: 33515644
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4. A Notch-Dependent Inflammatory Feedback Circuit between Macrophages and cancer Cells Regulates pancreatic cancer Metastasis.
Geng Y; Fan J; Chen L; Zhang C; Qu C; Qian L; Chen K; Meng Z; Chen Z; Wang P
Cancer Res; 2021 Jan; 81(1):64-76. PubMed ID: 33172931
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5. Gemcitabine treatment induces endoplasmic reticular (ER) stress and subsequently upregulates urokinase plasminogen activator (upa) to block mitochondrial-dependent apoptosis in Panc-1 cancer stem-like cells (CSCs).
Wang L; Zhang Y; Wang W; Zhu Y; Chen Y; Tian B
PLoS One; 2017; 12(8):e0184110. PubMed ID: 28854261
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6. SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris NLE; Vennin C; Conway JRW; Vine KL; Pinese M; Cowley MJ; Shearer RF; Lucas MC; Herrmann D; Allam AH; Pajic M; Morton JP; ; Biankin AV; Ranson M; Timpson P; Saunders DN
Oncogene; 2017 Jul; 36(30):4288-4298. PubMed ID: 28346421
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7. Colon cancer-derived myofibroblasts increase endothelial cell migration by glucocorticoid-sensitive secretion of a pro-migratory factor.
Drebert Z; MacAskill M; Doughty-Shenton D; De Bosscher K; Bracke M; Hadoke PWF; Beck IM
Vascul Pharmacol; 2017 Feb; 89():19-30. PubMed ID: 27717848
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8. Identification of pancreatic tumors in vivo with ligand-targeted, pH responsive mesoporous silica nanoparticles by multispectral optoacoustic tomography.
Gurka MK; Pender D; Chuong P; Fouts BL; Sobelov A; McNally MW; Mezera M; Woo SY; McNally LR
J Control Release; 2016 Jun; 231():60-7. PubMed ID: 26763377
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9. Hydrogen peroxide mediates hyperglycemia-induced invasive activity via ERK and p38 MAPK in human pancreatic cancer.
Li W; Ma Z; Ma J; Li X; Xu Q; Duan W; Chen X; Lv Y; Zhou S; Wu E; Ma Q; Huo X
Oncotarget; 2015 Oct; 6(31):31119-33. PubMed ID: 26439801
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10. Modulation of upa, MMPs and their inhibitors by a novel nutrient mixture in human colorectal, pancreatic and hepatic carcinoma cell lines.
Roomi MW; Kalinovsky T; Niedzwiecki A; Rath M
Int J Oncol; 2015 Jul; 47(1):370-6. PubMed ID: 25997494
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11. The role of the hepatocyte growth factor/c-MET pathway in pancreatic stellate cell-endothelial cell interactions: antiangiogenic implications in pancreatic cancer.
Patel MB; Pothula SP; Xu Z; Lee AK; Goldstein D; Pirola RC; Apte MV; Wilson JS
Carcinogenesis; 2014 Aug; 35(8):1891-900. PubMed ID: 24876152
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12. Oncogenic K-Ras and loss of Smad4 mediate invasion by activating an EGFR/NF-κB Axis that induces expression of MMP9 and upa in human pancreas progenitor cells.
Bera A; Zhao S; Cao L; Chiao PJ; Freeman JW
PLoS One; 2013; 8(12):e82282. PubMed ID: 24340014
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13. Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer.
Shrimali D; Shanmugam MK; Kumar AP; Zhang J; Tan BK; Ahn KS; Sethi G
Cancer Lett; 2013 Dec; 341(2):139-49. PubMed ID: 23962559
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14. Phase II randomised proof-of-concept study of the urokinase inhibitor upamostat (WX-671) in combination with gemcitabine compared with gemcitabine alone in patients with non-resectable, locally advanced pancreatic cancer.
Heinemann V; Ebert MP; Laubender RP; Bevan P; Mala C; Boeck S
Br J Cancer; 2013 Mar; 108(4):766-70. PubMed ID: 23412098
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15. Theranostic nanoparticles with controlled release of gemcitabine for targeted therapy and MRI of pancreatic cancer.
Lee GY; Qian WP; Wang L; Wang YA; Staley CA; Satpathy M; Nie S; Mao H; Yang L
ACS Nano; 2013 Mar; 7(3):2078-89. PubMed ID: 23402593
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16. TRAIL-induced expression of upa and IL-8 strongly enhanced by overexpression of TRAF2 and Bcl-xL in pancreatic ductal adenocarcinoma cells.
Zhou DH; Yang LN; Roder C; Kalthoff H; Trauzold A
Hepatobiliary Pancreat Dis Int; 2013 Feb; 12(1):94-8. PubMed ID: 23392805
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17. Gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1.
Wang C; Zhang H; Chen Y; Shi F; Chen B
Int J Nanomedicine; 2012; 7():781-7. PubMed ID: 22393285
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18. Suppression of upa and upaR blocks radiation-induced MCP-1 mediated recruitment of endothelial cells in meningioma.
Nalla AK; Gogineni VR; Gupta R; Dinh DH; Rao JS
Cell Signal; 2011 Aug; 23(8):1299-310. PubMed ID: 21426933
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19. Suppression of upa and upaR attenuates angiogenin mediated angiogenesis in endothelial and glioblastoma cell lines.
Raghu H; Lakka SS; Gondi CS; Mohanam S; Dinh DH; Gujrati M; Rao JS
PLoS One; 2010 Aug; 5(8):e12458. PubMed ID: 20805979
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20. Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling.
Xue A; Xue M; Jackson C; Smith RC
Int J Biochem Cell Biol; 2009; 41(8-9):1731-8. PubMed ID: 19433314
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