Terms: = Sarcomas AND CDK12, KIAA0904, CRKRS, 51755, ENSG00000167258, CRK7, CRKR, Q9NYV4
5 results:
1. Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual cdk12/13 covalent inhibitor with efficacy in Ewing sarcoma.
Jiang B; Jiang J; Kaltheuner IH; Iniguez AB; Anand K; Ferguson FM; Ficarro SB; Seong BKA; Greifenberg AK; Dust S; Kwiatkowski NP; Marto JA; Stegmaier K; Zhang T; Geyer M; Gray NS
Eur J Med Chem; 2021 Oct; 221():113481. PubMed ID: 33945934
[TBL] [Abstract] [Full Text] [Related]
2. Cyclin-dependent kinase 12 (cdk12) in chordoma: prognostic and therapeutic value.
Thanindratarn P; Dean DC; Feng W; Wei R; Nelson SD; Hornicek FJ; Duan Z
Eur Spine J; 2020 Dec; 29(12):3214-3228. PubMed ID: 32691223
[TBL] [Abstract] [Full Text] [Related]
3. Ex vivo screen identifies cdk12 as a metastatic vulnerability in osteosarcoma.
Bayles I; Krajewska M; Pontius WD; Saiakhova A; Morrow JJ; Bartels C; Lu J; Faber ZJ; Fedorov Y; Hong ES; Karnuta JM; Rubin B; Adams DJ; George RE; Scacheri PC
J Clin Invest; 2019 Oct; 129(10):4377-4392. PubMed ID: 31498151
[TBL] [Abstract] [Full Text] [Related]
4. cdk12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling.
Henry KL; Kellner D; Bajrami B; Anderson JE; Beyna M; Bhisetti G; Cameron T; Capacci AG; Bertolotti-Ciarlet A; Feng J; Gao B; Hopkins B; Jenkins T; Li K; May-Dracka T; Murugan P; Wei R; Zeng W; Allaire N; Buckler A; Loh C; Juhasz P; Lucas B; Ennis KA; Vollman E; Cahir-McFarland E; Hett EC; Ols ML
Sci Signal; 2018 Jul; 11(541):. PubMed ID: 30065029
[TBL] [Abstract] [Full Text] [Related]
5. EWS/FLI Confers Tumor Cell Synthetic Lethality to cdk12 Inhibition in Ewing Sarcoma.
Iniguez AB; Stolte B; Wang EJ; Conway AS; Alexe G; Dharia NV; Kwiatkowski N; Zhang T; Abraham BJ; Mora J; Kalev P; Leggett A; Chowdhury D; Benes CH; Young RA; Gray NS; Stegmaier K
Cancer Cell; 2018 Feb; 33(2):202-216.e6. PubMed ID: 29358035
[TBL] [Abstract] [Full Text] [Related]
