Terms: = Sarcomas AND PTPN11, CFC, Q06124, 5781, ENSG00000179295, SHP2, MGC14433, SHP-2, BPTP3, PTP-1D, SH-PTP3, NS1, SH-PTP2, PTP2C AND Treatment
14 results:
1. Phase separation of shp2E76K promotes malignant transformation of mesenchymal stem cells by activating mitochondrial complexes.
Kan C; Tan Z; Liu L; Liu B; Zhan L; Zhu J; Li X; Lin K; Liu J; Liu Y; Yang F; Wong M; Wang S; Zheng H
JCI Insight; 2024 Mar; 9(8):. PubMed ID: 38451719
[TBL] [Abstract] [Full Text] [Related]
2. From bench to bedside: current development and emerging trend of KRAS-targeted therapy.
Chen Y; Liu QP; Xie H; Ding J
Acta Pharmacol Sin; 2024 Apr; 45(4):686-703. PubMed ID: 38049578
[TBL] [Abstract] [Full Text] [Related]
3. CDK4/6 inhibition enhances shp2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors.
Wang J; Calizo A; Zhang L; Pino JC; Lyu Y; Pollard K; Zhang X; Larsson AT; Conniff E; Llosa NJ; Wood DK; Largaespada DA; Moody SE; Gosline SJ; Hirbe AC; Pratilas CA
Sci Adv; 2023 Nov; 9(47):eadg8876. PubMed ID: 38000020
[TBL] [Abstract] [Full Text] [Related]
4. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based shp2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the treatment of KRAS Mutant Cancers.
Hou Q; Jiang W; Li W; Huang C; Yang K; Chen X; Huang M; Shu C; Luo G; Sun H; Chu Q; Wu X
J Med Chem; 2023 Oct; 66(19):13646-13664. PubMed ID: 37754066
[TBL] [Abstract] [Full Text] [Related]
5. Selumetinib for Refractory Pulmonary and Gastrointestinal Bleeding in Noonan Syndrome.
Chakraborty A; Beasley G; Martinez H; Jesudas R; Anton-Martin P; Christakopoulos G; Kramer J
Pediatrics; 2022 Oct; 150(4):. PubMed ID: 36082608
[TBL] [Abstract] [Full Text] [Related]
6. Hexachlorophene, a selective shp2 inhibitor, suppresses proliferation and metastasis of KRAS-mutant NSCLC cells by inhibiting RAS/MEK/ERK and PI3K/AKT signaling pathways.
Fu NJ; Xi RY; Shi XK; Li RZ; Zhang ZH; Li LY; Zhang GL; Wang F
Toxicol Appl Pharmacol; 2022 Apr; 441():115988. PubMed ID: 35307375
[TBL] [Abstract] [Full Text] [Related]
7. Osteosarcoma cell proliferation suppression via shp-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A.
Zhu D; Chen C; Liu X; Wang S; Zhu J; Zhang H; Kong L; Luo J
J Adv Res; 2021 Dec; 34():79-91. PubMed ID: 35024182
[TBL] [Abstract] [Full Text] [Related]
8. Combined SHPments: An Effective Therapeutic Strategy for MPNST.
Aplin AE; Capparelli C
Cancer Res; 2021 Jan; 81(2):266-267. PubMed ID: 33452215
[TBL] [Abstract] [Full Text] [Related]
9. A novel TJP1-ROS1 fusion in malignant peripheral nerve sheath tumor responding to crizotinib: A case report.
Li J; Liu L; Zhang Q; Huang Y; Zhang Y; Gan X; Liu S; Yue Z; Wei Y
Medicine (Baltimore); 2020 Jun; 99(26):e20725. PubMed ID: 32590748
[TBL] [Abstract] [Full Text] [Related]
10. ptpn11 mutations in canine and human disseminated histiocytic sarcoma.
Hédan B; Rault M; Abadie J; Ulvé R; Botherel N; Devauchelle P; Copie-Bergman C; Cadieu E; Parrens M; Alten J; Zalcman EL; Cario G; Damaj G; Mokhtari K; Le Loarer F; Coulomb-Lhermine A; Derrien T; Hitte C; Bachelot L; Breen M; Gilot D; Blay JY; Donadieu J; André C
Int J Cancer; 2020 Sep; 147(6):1657-1665. PubMed ID: 32212266
[TBL] [Abstract] [Full Text] [Related]
11. Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.
Toomey S; Carr A; Mezynski MJ; Elamin Y; Rafee S; Cremona M; Morgan C; Madden S; Abdul-Jalil KI; Gately K; Farrelly A; Kay EW; Kennedy S; O'Byrne K; Grogan L; Breathnach O; Morris PG; Eustace AJ; Fay J; Cummins R; O'Grady A; Kalachand R; O'Donovan N; Kelleher F; O'Reilly A; Doherty M; Crown J; Hennessy BT
J Transl Med; 2020 Feb; 18(1):99. PubMed ID: 32087721
[TBL] [Abstract] [Full Text] [Related]
12. Rare myeloid sarcoma with KMT2A (MLL)-ELL fusion presenting as a vaginal wall mass.
Bao H; Gao J; Chen YH; Altman JK; Frankfurt O; Wilson AL; Sukhanova M; Chen Q; Lu X
Diagn Pathol; 2019 Mar; 14(1):26. PubMed ID: 30922345
[TBL] [Abstract] [Full Text] [Related]
13. HGF-independent regulation of MET and GAB1 by nonreceptor tyrosine kinase FER potentiates metastasis in ovarian cancer.
Fan G; Zhang S; Gao Y; Greer PA; Tonks NK
Genes Dev; 2016 Jul; 30(13):1542-57. PubMed ID: 27401557
[TBL] [Abstract] [Full Text] [Related]
14. Molecular Heterogeneity of Ewing Sarcoma as Detected by Ion Torrent Sequencing.
Zhang N; Liu H; Yue G; Zhang Y; You J; Wang H
PLoS One; 2016; 11(4):e0153546. PubMed ID: 27077911
[TBL] [Abstract] [Full Text] [Related]
