Terms: = Skin cancer AND MAP2K1, MAPKK1, 5604, ENSG00000169032, Q02750, MEK1, MKK1, PRKMK1 AND Treatment
125 results:
1. treatment experience with encorafenib plus binimetinib for BRAF V600-mutant metastatic melanoma: management insights for clinical practice.
Augustyn K; Joseph J; Patel AB; Razmandi A; Ali AN; Tawbi HA
Melanoma Res; 2023 Oct; 33(5):406-416. PubMed ID: 37534686
[TBL] [Abstract] [Full Text] [Related]
2. Protein phosphatase 6 regulates trametinib sensitivity, a mitogen-activated protein kinase kinase (MEK) inhibitor, by regulating mek1/2-ERK1/2 signaling in canine melanoma cells.
Yamamoto M; Fujiwara N
J Vet Med Sci; 2023 Sep; 85(9):977-984. PubMed ID: 37495516
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3. Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response.
Randic T; Magni S; Philippidou D; Margue C; Grzyb K; Preis JR; Wroblewska JP; Nazarov PV; Mittelbronn M; Frauenknecht KBM; Skupin A; Kreis S
Cell Rep; 2023 Jul; 42(7):112696. PubMed ID: 37379213
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4. Trametinib in Patients With
Wisinski KB; Flamand Y; Wilson MA; Luke JJ; Tawbi HA; Hong F; Mitchell EP; Zwiebel JA; Chen H; Gray RJ; Li S; McShane LM; Rubinstein LV; Patton D; Williams PM; Hamilton SR; Behrens RJ; Pennington KP; Conley BA; Arteaga CL; Harris LN; O'Dwyer PJ; Chen AP; Flaherty KT
JCO Precis Oncol; 2023 Apr; 7():e2200421. PubMed ID: 37053535
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5. Natural killer cells suppress human cutaneous squamous cell carcinoma cancer cell survival and tumor growth.
Adhikary G; Heipertz EL; Preradovic M; Chen X; Xu W; Newland JJ; Kaur N; Vemuri MC; Eckert RL
Mol Carcinog; 2023 Jun; 62(6):845-854. PubMed ID: 36994661
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6. Optically activated mek1/2 inhibitors (Opti-MEKi) as potential antimelanoma agents.
Hao C; Li X; Wang Z; Liu L; He F; Pan Z
Eur J Med Chem; 2023 May; 251():115236. PubMed ID: 36924668
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7. Dabrafenib, alone or in combination with trametinib, in BRAF V600-mutated pediatric Langerhans cell histiocytosis.
Whitlock JA; Geoerger B; Dunkel IJ; Roughton M; Choi J; Osterloh L; Russo M; Hargrave D
Blood Adv; 2023 Aug; 7(15):3806-3815. PubMed ID: 36884302
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8. Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and mek1/2.
Wang P; Jia X; Lu B; Huang H; Liu J; Liu X; Wu Q; Hu Y; Li P; Wei H; Liu T; Zhao D; Zhang L; Tian X; Jiang Y; Qiao Y; Nie W; Ma X; Bai R; Peng C; Dong Z; Liu K
Signal Transduct Target Ther; 2023 Mar; 8(1):96. PubMed ID: 36872366
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9. High-Throughput Functional Evaluation of map2k1 Variants in cancer.
Mizuno S; Ikegami M; Koyama T; Sunami K; Ogata D; Kage H; Yanagaki M; Ikeuchi H; Ueno T; Tanikawa M; Oda K; Osuga Y; Mano H; Kohsaka S
Mol Cancer Ther; 2023 Feb; 22(2):227-239. PubMed ID: 36442478
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10. Cobimetinib Plus Vemurafenib in Patients With Colorectal cancer With
Klute KA; Rothe M; Garrett-Mayer E; Mangat PK; Nazemzadeh R; Yost KJ; Duvivier HL; Ahn ER; Cannon TL; Alese OB; Krauss JC; Thota R; Calfa CJ; Denlinger CS; O'Lone R; Halabi S; Grantham GN; Schilsky RL
JCO Precis Oncol; 2022 Nov; 6():e2200191. PubMed ID: 36409971
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11. A first-in-human, phase 1a dose-escalation study of the selective mek1/2 inhibitor FCN-159 in patients with advanced NRAS-mutant melanoma.
Mao L; Guo J; Zhu L; Jiang Y; Yan W; Zhang J; Hui AM; Yang Y; Diao L; Tan Y; Zhao H; Jiang Y; Wu Z; Si L
Eur J Cancer; 2022 Nov; 175():125-135. PubMed ID: 36113242
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12. Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study.
Trippett T; Toledano H; Campbell Hewson Q; Verschuur A; Langevin AM; Aerts I; Howell L; Gallego S; Rossig C; Smith A; Patel D; Pereira LR; Cheeti S; Musib L; Hutchinson KE; Devlin C; Bernardi R; Geoerger B
Target Oncol; 2022 May; 17(3):283-293. PubMed ID: 35715627
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13. A Genome-Wide Screen Identifies PDPK1 as a Target to Enhance the Efficacy of mek1/2 Inhibitors in NRAS Mutant Melanoma.
Cai W; Nguyen MQ; Wilski NA; Purwin TJ; Vernon M; Tiago M; Aplin AE
Cancer Res; 2022 Jul; 82(14):2625-2639. PubMed ID: 35657206
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14. Intermittent treatment of BRAF
Kavran AJ; Stuart SA; Hayashi KR; Basken JM; Brandhuber BJ; Ahn NG
Proc Natl Acad Sci U S A; 2022 Mar; 119(12):e2113535119. PubMed ID: 35290123
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15. The Predictive Value of
Ye T; Zhang JY; Liu XY; Zhou YH; Yuan SY; Yang MM; Xie WZ; Gao C; Chen YX; Huang ML; Ye CZ; Chen J
Front Immunol; 2021; 12():785526. PubMed ID: 35069558
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16. Merkel cell polyomavirus-negative Merkel cell carcinoma is associated with JAK-STAT and MEK-ERK pathway activation.
Iwasaki T; Hayashi K; Matsushita M; Nonaka D; Kohashi K; Kuwamoto S; Umekita Y; Oda Y
Cancer Sci; 2022 Jan; 113(1):251-260. PubMed ID: 34724284
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17. Neratinib kills B-RAF V600E melanoma via ROS-dependent autophagosome formation and death receptor signaling.
Dent P; Booth L; Poklepovic A; Kirkwood JM
Pigment Cell Melanoma Res; 2022 Jan; 35(1):66-77. PubMed ID: 34482636
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18. Phase II Trial of Trametinib and Panitumumab in RAS/RAF Wild Type Metastatic Colorectal cancer.
Alshammari K; Aung KL; Zhang T; Razak ARA; Serra S; Stockley T; Wang L; Nguyen J; Spreafico A; Hansen AR; Zwir D; Siu LL; Bedard PL
Clin Colorectal Cancer; 2021 Dec; 20(4):334-341. PubMed ID: 34417144
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19. Paclitaxel anticancer activity is enhanced by the MEK 1/2 inhibitor PD98059 in vitro and by PD98059-loaded nanoparticles in BRAF
Mekkawy AI; Naguib YW; Alhaj-Suliman SO; Wafa EI; Ebeid K; Acri T; Salem AK
Int J Pharm; 2021 Sep; 606():120876. PubMed ID: 34252520
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20. High tumour mutational burden and EGFR/MAPK pathway activation are therapeutic targets in metastatic porocarcinoma.
Westphal D; Garzarolli M; Sergon M; Horak P; Hutter B; Becker JC; Wiegel M; Maczey E; Blum S; Grosche-Schlee S; Rütten A; Ugurel S; Stenzinger A; Glimm H; Aust D; Baretton G; Beissert S; Fröhling S; Redler S; Surowy H; Meier F
Br J Dermatol; 2021 Dec; 185(6):1186-1199. PubMed ID: 34185311
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