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  • Title: A morphometric investigation of the duodenal mucosa of normal, vitamin D-deficient, and vitamin D-replete rats.
    Author: Sampson HW, Krawitt EL.
    Journal: Calcif Tissue Res; 1976 Dec 02; 21(3):213-8. PubMed ID: 1000338.
    Abstract:
    Light and electron microscopy were utilized to determine differences in morphology and size in duodenal villi and microvilli from normal, vitamin D-deficient, and vitamin D-replete rats. An increase in villus diameter and surface area was observed in vitamin D-deficient rats. Administration of vitamin D reversed the increase in diameter but the height of villi increased resulting in longer, thinner villi without a significant change in surface area. A decrease in microvillus surface area seen in vitamin D-deficient animals was reversed by the administration of vitamin D.
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