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  • Title: Early morning hydroxyproline excretion in patients with breast cancer.
    Author: Powles TJ, Rosset G, Leese CL, Bondy PK.
    Journal: Cancer; 1976 Dec; 38(6):2564-6. PubMed ID: 1000483.
    Abstract:
    The hydroxyproline/creatinine excretion ratios have been measured in half-hour fasting morning urine specimens from breast cancer patients and compared with corresponding values measured in 24 hour urine collections. Both parameters show a close correlation. The value of the half-hour test in predicting the presence of early bone metastases, in monitoring the response of patients to therapy and in eliminating unwanted effects of dietary Hydroxyproline intake are discussed.
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