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  • Title: [Combination of clofibrate and phenformin in the treatment of endogenous hypertriglyceridaemia (author's transl)].
    Author: Vogelberg KH.
    Journal: Dtsch Med Wochenschr; 1976 Dec 17; 101(51):1868-71. PubMed ID: 1001205.
    Abstract:
    Combined treatment with clofibrate and phenformin increased the lipid-lowering effect of clofibrate monotherapy in 15 patients with endogenous hypertriglyceridaemia significantly by ca. 10%. The therapeutic success was shown by a reduction in LDL-cholesterol and an additional reduction in VLDL-triglycerides. A clofibrate-induced rise in LDL-cholesterol could not be observed during the combined treatment. Thus combined treatment could be particularly advantageous in the prophylaxis of arteriosclerotic complications of endogenous hypertriglyceridaemia, provided that contra-indications of either of the preparations are excluded.
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