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  • Title: [Erythropoietic protoporthyria. Clinical aspects and therapy].
    Author: Beckert E, Metz J.
    Journal: Fortschr Med; 1976 Dec 02; 94(34):1981-6, 1995. PubMed ID: 1002089.
    Abstract:
    After introduction in clinical, histological and ultrastructural features of erythropoietic protoporphyria the therapeutic effect of beta-Carotene is reported in 5 patients with erythropoietic proporphyria and in 1 patient with polymorphous light dermatosis. beta-Carotene was given orally in a daily initial dose of 50-100 mg, continued with 25 mg a day. In all patients the therapeutic effect set on about 2 months after beginning of the treatment and was measured by increased toleration to insolation. During the treatment over a period of four years no side effects were noticed by 127 clinical and biochemical controls beside a dose-dependent "icterus" localized as well in the perioral region as on the hands and feet.
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