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  • Title: Why are there so few resistance-associated mutations in insecticide target genes?
    Author: ffrench-Constant RH, Pittendrigh B, Vaughan A, Anthony N.
    Journal: Philos Trans R Soc Lond B Biol Sci; 1998 Oct 29; 353(1376):1685-93. PubMed ID: 10021768.
    Abstract:
    The genes encoding the three major targets of conventional insecticides are: Rdl, which encodes a gamma-aminobutyric acid receptor subunit (RDL); para, which encodes a voltage-gated sodium channel (PARA); and Ace, which encodes insect acetylcholinesterase (AChE). Interestingly, despite the complexity of the encoded receptors or enzymes, very few amino acid residues are replaced in different resistant insects: one within RDL, two within PARA and three or more within AChE. Here we examine the possible reasons underlying this extreme conservation by looking at the aspects of receptor and/or enzyme function that may constrain replacements to such a limited number of residues.
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