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  • Title: Human puberty: 24-hour estradiol in pubertal girls.
    Author: Boyar RM, Wu RH, Roffwarg H, Kapen S, Weitzman ED, Hellman L, Finkelstein JW.
    Journal: J Clin Endocrinol Metab; 1976 Dec; 43(6):1418-21. PubMed ID: 1002825.
    Abstract:
    Plasma luteinizing hormone, follicle-stimulating hormone, and estradiol were measured at 20-minute intervals for 24-hours in seven pubertal premenarchal girls whose sleep was monitored polygraphically. A circadian variation in plasma estradiol was demonstrated with the highest values occurring during the day (1400-1600 hours) and lowest values during sleep, a time when gonadotropin secretion was augmented.
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