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  • Title: Penetration of protein tracers into the epiretinal portion of the optic nerve in the rabbit nerve.
    Author: Kristensson K, Wiśniewski HM.
    Journal: J Neurol Sci; 1976 Dec; 30(2-3):411-6. PubMed ID: 1003255.
    Abstract:
    Horseradish peroxidase and fluorescein-labelled globulin were injected into the vitreous of adult and 11- to 13-day-old New Zealand albino rabbits. Both tracers diffused rapidly into the myelinated nerve fibre layer (the "medullary rays"), which extends over a long distance within the retina in these animals. The tracers penetrated also for some distance into the optic nerve beyond the lamina cribosa, where they were incorporated into a large number of cells in the nerve. This finding of a rapid diffusion of macromolecules into the medullary rays after intravitreal injection makes this experimental model suitable for the study of factors interfering with myelin or myelination.
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