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  • Title: Deuterium isotope effect in the microsomal metabolism of dimethylnitrosamine.
    Author: Dagani D, Archer MC.
    Journal: J Natl Cancer Inst; 1976 Oct; 57(4):955-7. PubMed ID: 1003536.
    Abstract:
    The rates of N-demethylation of dimethylnitrosamine and dimethylnitrosamine-d6 by rat liver microsomes were studied by monitoring formaldehyde production. Deuterium isotope effects of 1.6 and 3.8 were found for the Michaelis constant and the maximum velocity, respectively.
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