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  • Title: Posterior vitreous detachment induced by injection of plasmin and sulfur hexafluoride in the rabbit vitreous.
    Author: Hikichi T, Yanagiya N, Kado M, Akiba J, Yoshida A.
    Journal: Retina; 1999; 19(1):55-8. PubMed ID: 10048374.
    Abstract:
    PURPOSE: To investigate whether an injection of plasmin and sulfur hexafluoride (SF6) can induce posterior vitreous detachment (PVD) without vitrectomy. METHODS: One eye each of 15 New Zealand white rabbits was assigned to one of three groups. Eyes in group 1 received a vitreous injection of 1 unit of human plasmin (0.1 mL reconstituted in balanced salt solution) and 0.5 mL of SF6; eyes in group 2 received a vitreous injection of plasmin alone; eyes in group 3 received a vitreous injection of SF6 alone. Seven days after injection, all animals were monitored electroretinographically and killed, and the eyes were enucleated. After fixation, scanning electron microscopy was performed. RESULTS: In group 1 eyes, the retinal surface was smooth except for the vitreous base, which showed complete separation of the vitreous cortex from the retina, indicating PVD. In group 2 and 3 eyes, sparse collagen fibers remained on the retinal surface. CONCLUSION: Vitreous injection of plasmin combined with SF6 can induce PVD without vitrectomy.
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