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  • Title: Biophysical characterization of the oligomeric state of Bax and its complex formation with Bcl-XL.
    Author: Tan YJ, Beerheide W, Ting AE.
    Journal: Biochem Biophys Res Commun; 1999 Feb 16; 255(2):334-9. PubMed ID: 10049709.
    Abstract:
    The overexpression of Bax, a member of the Bcl-2 family, promotes cell death and the dimerization (or oligomerization) of Bax has been shown to be important for its function. Using size-exclusion chromatography and in vitro cross-linking experiments, we demonstrated that Bax exists mainly as a large oligomer of approximately 30 monomeric units. Furthermore, several binding assays demonstrated that Bcl-XL, an anti-apoptotic member of the Bcl-2 family, can bind to the oligomeric form of Bax without requiring Bax to dissociate to monomers.
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