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  • Title: [Treatment of CMV retinitis with intravitreal foscarnet].
    Author: Cochereau I, Belayachi N, Diraison C, Matheron S, Bouyer I, Hoang-Xuan T, Saimot AG, Coulaud JP.
    Journal: J Fr Ophtalmol; 1998 Dec; 21(10):723-6. PubMed ID: 10052044.
    Abstract:
    PURPOSE: To assess the tolerability and efficacy of intravitreal injections of foscarnet in cytomegalovirus (CMV) retinitis in acquired immunodeficiency syndrome (AIDS). METHODS: Patients with CMV retinitis resistant and/or intolerant to intravenous foscarnet and ganciclovir and resistant to intravitreal ganciclovir were included. The induction therapy consisted of intravitreal injections of 2,400 micrograms of foscarnet twice a week. The assessment was performed by clinical examination and photographies of the fundus. RESULTS: Three patients (four eyes) have been included. Three eyes were administered seven and one eye eight intravitreal injections. The tolerability was good, but the efficacy was mere: the retinal lesions became less edematous, but they still extended. CONCLUSION: In these four eyes with CMV retinitis resistant to intravitreal ganciclovir, intravitreal injections of foscarnet were well tolerated but did not stop the progression of the retinitis.
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