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  • Title: Dietary effect of EPA-rich and DHA-rich fish oils on the immune function of Sprague-Dawley rats.
    Author: Hung P, Kaku S, Yunoki S, Ohkura K, Gu JY, Ikeda I, Sugano M, Yazawa K, Yamada K.
    Journal: Biosci Biotechnol Biochem; 1999 Jan; 63(1):135-40. PubMed ID: 10052133.
    Abstract:
    The dietary effect of fish oils (FOs) rich in eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) on the immune function of Sprague-Dawley rats was compared with that of safflower oil. After 3 weeks of feeding at the 10% level of a dietary fat, the IgG and IgM production by splenocytes and IgG production by mesenteric lymph node (MLN) lymphocytes were significantly higher in the FO-fed rats, while no significant difference was found in IgA or IgE productivity by both the spleen and MLN lymphocytes. In the FO-fed rats, peritoneal exudate cells released a lower amount of LTB4, reflecting their lower arachidonic acid level, and a higher amount of LTB5, reflecting their higher EPA level in phospholipids. On these EPA-rich FO exerted a stronger effect than DHA-rich FO immune functions.
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