These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The effect of reported prostaglandin synthetase inhibitors on estradiol-stimulated uterine prostaglandin biosynthesis in vivo in the ovariectomized rat.
    Author: Jordan VC, Castracane VD.
    Journal: Prostaglandins; 1976 Dec; 12(6):1073-81. PubMed ID: 1005739.
    Abstract:
    Aspirin, indomethacin and naproxen have been shown to inhibit the release of prostaglandins E and F (PGE and PGF) from the estradiol-stimulated uterus of progesterone-pretreated ovariectomized rats. Under the present experimental conditions indomethacin (1 mg/rat) was found to be a potent inhibitor of PGF and E biosynthesis, but the duration of action was less than 24 hours, after which a rebound above control levles was observed.The compounds were without effect on estradiol-stimulated increases in uterine wet weight. delta'THC did not inhibit estradiol-stimulated PG biosynthesis but produced a significant rise (P less than 0.01) in PGE levels in uterine venous blood. A hypothesis is suggested to explain some of the pharmacological effects of delta'THC.
    [Abstract] [Full Text] [Related] [New Search]