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  • Title: Relationship between resistance to complement, virulence and outer membrane protein patterns in pathogenic Escherichia coli O2 isolates.
    Author: Chaffer M, Heller ED, Schwartsburd B.
    Journal: Vet Microbiol; 1999 Feb 12; 64(4):323-32. PubMed ID: 10063537.
    Abstract:
    To establish a possible relationship between resistance to complement, virulence and outer membrane protein banding patterns, ten E. coli O2 strains isolated from chickens with colibacillosis were studied for: (1) resistance to the bactericidal effect of complement by a quantitative microtiter method, (2) virulence, as determined by chicken lethality test, and (3) outer membrane protein banding patterns yielded by SDS-polyacrylamide gel electrophoresis. The ten isolates were classified into three groups: (1) Group 1, consisting of four isolates showed: (a) high resistance to complement, (b) high virulence, and (c) different pattern between 35 and 40 kDa with a weak peptide band at 35 kDa. (2) Group 2, consisting of one isolate showed: (a) high resistance to complement, (b) low virulence, and (c) a weak peptide band at 35 kDa. (3) Group 3, consisting of five isolates showed: (a) low resistance to complement, (b) low virulence, and (c) identical OMP pattern between 35 and 40 kDa exhibiting a strong peptide band at 35 kDa. The results suggest that high resistance to complement may be necessary but no sufficient for virulence and that OMP banding patterns may be a marker for virulence.
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