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  • Title: [Treatment with 5-FU modulated by low-dose CDDP for advanced cancers and recurrent cases of metastasis].
    Author: Shinkai K, Kida H, Hisano H, Shibasaki S, Yano H, Nomura M.
    Journal: Gan To Kagaku Ryoho; 1999 Feb; 26(3):329-32. PubMed ID: 10065096.
    Abstract:
    Advanced gastric, colon and esophageal cancers (n = 21) were treated with 5-FU (250 mg) modulated by CDDP (5 mg). The reductive ratio of tumor was 6/21 (28.6%). Six cases of partial response (PR) were limited with no surgical treatment and exploratory laparotomy of all cases, and the effectiveness rate was 54.5% (6/11). Few side effects, such as dysfunction of bone marrow and kidney, were noted. Even if side effects occurred, they were mild. We concluded that excellent treatment with 5-FU modulated by CDDP has markedly improved the efficacy.
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