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  • Title: [Vertical HIV-I-transmission. II. HIV-diagnosis in a child].
    Author: Orendi JM, Geelen SP, de Graeff-Meeder ER, van Loon AM, Schuurman R, Boucher CA.
    Journal: Ned Tijdschr Geneeskd; 1998 Dec 12; 142(50):2724-8. PubMed ID: 10065236.
    Abstract:
    In newborn children from HIV-infected women early establishment of HIV infection is of importance for optimal therapy of HIV-infected children and avoidance of unnecessary medication in uninfected children. A more than 95% reliable diagnosis of HIV infection can now be obtained at the age of four weeks by polymerase chain reaction (PCR) technology. Before this age a positive PCR result is relevant since it necessitates additional investigation such as measuring anti-HIV drug resistance and may lead to modification of anti-HIV treatment. Prophylaxis against Pneumocystis carinii is not needed if HIV infection can not be demonstrated by PCR after the age of four weeks.
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