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  • Title: Type I beta-lactamases of Enterobacter cloacae and resistance to beta-lactam antibiotics.
    Author: Tejedor-Junco MT, González-Martín M, Lupiola P, González-Lama Z.
    Journal: Folia Microbiol (Praha); 1998; 43(6):683-6. PubMed ID: 10069013.
    Abstract:
    The interaction of type-I beta-lactamases from Enterobacter cloacae with diverse beta-lactam compounds was examined. The ability of penicillin and cefoxitin to induce beta-lactamase production in this strain was assessed. The effect of beta-lactamase inhibitors was measured on beta-lactamase extracts and on intact cells. E. cloacae 78 strain is a stably derepressed mutant showing limited susceptibility to a number of antibiotics except imipenem. Imipenem would therefore be the appropriate choice for therapy of infections caused by stably derepressed mutants of Enterobacter sp. producing type-I beta-lactamases.
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