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  • Title: Osteopenia due to chronic alcohol consumption by young actively growing rats is not completely reversible.
    Author: Sampson HW, Spears H.
    Journal: Alcohol Clin Exp Res; 1999 Feb; 23(2):324-7. PubMed ID: 10069563.
    Abstract:
    Our project was conducted to determine if the deleterious effects of chronic alcohol consumption on growing bone are reversible if the adolescent stops drinking. Four-week old, female, Sprague-Dawley rats were housed and maintained in an AAALAC-accredited facility. Six animals each were placed on alcohol-fed (35% ethanol-derived calories), pair-fed or chow-fed diets for 2 or 4 weeks. A recovery group of six animals was alcohol-fed for 2 weeks followed by an additional 2 weeks of chow feeding. This group was pair-fed to an additional group of six animals that received liquid diet, pair fed to the recovery group for 2 weeks followed by 2 weeks on a pair-fed chow diet. Blood alcohol concentrations averaged 309 +/- 9 mg/dl. Morphological parameters of the femur, such as length, diameter, and volume were smaller in alcohol treated animals at both 2 and 4 weeks of feeding. Femur length and volume of recovery alcohol-fed animals were more than either 2- or 4-week alcohol-fed animals, but they were not as great as the same-age 4-week pair-fed or chow-fed animals. Diameter was similar to the 4-week alcohol-fed, but less than the chow-fed. Femur density was reduced at all time periods in the alcohol-fed animals. The recovery alcohol-fed animals had greater density than the 2-week alcohol, but not the 4-week alcohol-fed animals. They did not, however, reach 4-week chow- or pair-fed levels. Tibia BV/TV was reduced in the 2- and 4-week alcohol- and pair-fed animals. BV/TV was greater in the recovery animals than either 2- or 4-week alcohols, but not as great as the chow-fed animals. At 2 weeks, calorie deprivation caused a reduction in insulin-like growth factor-1 (IGF-1) that was reduced even more by alcohol. By 4 weeks, the calorie deprivation was no longer seen, but alcohol continued to reduce the values. Two weeks of alcohol followed by 2 weeks of chow diet returned the IGF-1 values to almost normal, but significantly different levels. The apparent improvement was probably due to continued growth of the young bones and not a regaining of bone lost during alcohol consumption.
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