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  • Title: Budd-Chiari syndrome associated with factor V leiden mutation: a report of 6 patients.
    Author: Hoffman R, Nimer A, Lanir N, Brenner B, Baruch Y.
    Journal: Liver Transpl Surg; 1999 Mar; 5(2):96-100. PubMed ID: 10071347.
    Abstract:
    Budd-Chiari syndrome is characterized by hepatic venous outflow obstruction. Although myeloproliferative disorders are usually responsible for this severe thrombotic disorder, deficiency or dysfunction of the natural anticoagulants can be involved. Resistance to activated protein C caused by factor V Leiden mutation has been recently identified as a major cause of thrombophilia. We report 6 patients with Budd-Chiari syndrome associated with factor V Leiden mutation combined with another acquired thrombophilic state (myeloproliferative disorder and lupus anticoagulant in 3 cases) and without another thrombophilic disorder in the other 3 cases. We conclude that factor V Leiden mutation should be evaluated in any case of hepatic vein occlusion because the prevalence of this mutation in the general population is high.
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