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  • Title: Changes in cathepsin D activity of maternal tissues during lactation and weaning in rats.
    Author: Hernández-Montes H, Escudero I, Villalpando S.
    Journal: Arch Med Res; 1999; 30(1):10-3. PubMed ID: 10071418.
    Abstract:
    BACKGROUND: A loss of proteins from maternal tissues during lactation has been demonstrated. Protein loss could be explained by intracellular proteolysis. METHODS: Cathepsin D activity was studied in the liver, muscle and mammary gland of lactating and weaned rat dams. Lactation was studied at maximal milk production (L-14) and at the final stage of lactation (L-21). RESULTS: Basal activity (virgin rats) was three times higher in liver and mammary gland than in muscle. At both stages, L-14 and L-21, cathepsin D activity increased in liver (50%) as well as in the gland (164%), but no change was observed in muscle, when compared with controls. Twenty-four hours after litter separation, enzyme activity in the liver decreased to basal levels, while in the mammary gland cathepsin D activity showed a significant decrease but remained higher than control levels. CONCLUSION: Our results show that liver exhibits adaptive changes in the catabolism of proteins in response to the increased demands imposed by lactation on the maternal organism, and when the stimuli disappear activity returns to basal levels. The high activity in mammary gland indicates fast turnover of structures and biomolecules as an answer to the high synthetic activity in this tissue. Activity remained higher in the weaning rats, as a result of the regression process which the mammary gland is undergoing.
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