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  • Title: Chronic oral haloperidol and clozapine in rats: A behavioral evaluation.
    Author: Schmitt U, Dahmen N, Fischer V, Weigmann H, Rao ML, Reuss S, Hiemke C.
    Journal: Neuropsychobiology; 1999; 39(2):86-91. PubMed ID: 10072665.
    Abstract:
    The present study evaluated chronic oral treatment of rats with haloperidol or clozapine. Drugs were given in the drinking water for a 23-day period. Rat behavior was analyzed once a week in an open field. Rats ingested either 1.7 mg/kg haloperidol or 40 mg/kg clozapine daily. Blood serum analysis revealed concentrations of 6 ng/ml for haloperidol and 22 ng/ml for clozapine at the end of the treatment. Haloperidol decreased overall activity from the onset of treatment. Clozapine showed similar effects only on the last test day. Control animals showed a slight habituation in exploration-related parameters. In conclusion, these results indicate that oral drug administration through the drinking water is a suitable mode of noninvasive chronic treatment that led to sufficiently high drug levels to induce specific pharmacological effects in rats.
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