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  • Title: [Effects of hypoxia and taurine on vasoconstriction peptides from cultured bovine pulmonary arterial endothelial cells].
    Author: Yu Z, Li J, Sun B.
    Journal: Zhonghua Jie He He Hu Xi Za Zhi; 1997 Feb; 20(1):25-9. PubMed ID: 10072798.
    Abstract:
    OBJECTIVE: To study roles of endothein-1 (ET-1), angiotensin-II (AT-II) and endogenous digitalis-like factor (EDF) from cultured bovine pulmonary arterial endothelial cells (PAEC) in the pathogenesis of hypoxic pulmonary hypertension, and to evaluate whether Taurine is capable of protecting tissue cells from injury. METHODS: Culture of bovine pulmonary arterial endothelial cells and dot blot hybridization. RESULTS: PAEC cultured under hypoxia resulted in an increase in ET-1 mRNA expression. PAEC cultured under hypoxia induced increase in ET-1, AT-II and EDF release. By adding taurine to the culture medium, ET-1 mRNA express was inhibited. ET-1, AT-II and EDF release were inhibited. CONCLUSIONS: Expression of ET-1 mRNA and release of ET-1, AT-II and EDF from PAEC increased under hypoxia. Taurine can inhibit the hypoxia-induced expression of ET-1 mRNA of PAEC and reduce the release of ET-1, AT-II and EDF from PAEC.
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