These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Sorbitol accumulation in rats kept on diabetic condition for short and prolonged periods.
    Author: Ferraz M, Ishii-Iwamoto EL, Batista MR, Brunaldi K, Bazotte RB.
    Journal: Zhongguo Yao Li Xue Bao; 1997 Jul; 18(4):309-11. PubMed ID: 10072911.
    Abstract:
    AIM: To study the influence of the course of diabetes, aging, and glycemia on the sorbitol accumulation in diabetic rats. METHODS: Streptozocin (Str) diabetic rats were obtained by Str i.v. (35 mg.kg-1). Glycemia and sorbitol levels from sciatic nerve and lens were measured after 1 d, 2, 5, and 8 months of diabetes. Sorbitol concentrations in serum, heart, diaphragm, small intestine, and kidney after 8 months of diabetes were measured. RESULTS: Diabetic rats after Str injection showed hyperglycemia (> 1.7 g.L-1), hyperphagia, polyuria, polydipsia, and loss of body weight. Sorbitol levels in lens and sciatic nerve increased in normal and diabetic rats; the increase was higher in diabetic rats. No relationship was shown between glycemia and sorbitol levels. An increased sorbitol level after 8 months of diabetes was found in small intestine and kidney. CONCLUSION: The sorbitol levels increased in lens and sciatic nerve with aging and this process was accelerated by diabetes.
    [Abstract] [Full Text] [Related] [New Search]