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  • Title: [The expression of HSP-70 gene in exocrine pancreas of the rats suffering from acute necrotizing pancreatitis].
    Author: Zhang L, Zhang H, Liu R.
    Journal: Zhongguo Ying Yong Sheng Li Xue Za Zhi; 1997 Feb; 13(1):46-9. PubMed ID: 10074314.
    Abstract:
    With the acute necrotizing pancreatitis rat model induced by giving sodium taurocholate, the expression of hsp70 gene was detected in exocrine pancreas using Northern hybridization and immunohistochemistry. Nothern hybridization analysis showed that the levels of hsp70 gene expression increased and peaked at 1 h after operation, and declined to the control levels at 8-16 h. In immunohistochemistry detection, the staining for HSP70 protein enhanced significantly at 1 h, peaked at 2 h, and then decreased, persisting for 16 h or longer. The location of the large particle positive signal for HSP70 was in the apical region of the acinar cells, while very few signals for HSP70 were observed in the basal region, nucleus and acinar lumen. The results suggest that the high expression of hsp70 gene in the acinar cells may be involved in the transportation of pancrease enzymes synthesized excessively and in the prevention of early enzyme activation.
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